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MGI:Zfp36
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Zfp36 ( synonyms: Nup475, Tis11, Tristetraprolin, Ttp, Zfp-36 ) | |
| Protein Name(s) | zinc finger protein 36, | |
| External Links | ||
| MGI | MGI:99180 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5301204 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0000288 |
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
MGI:MGI:3589099 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000289 |
nuclear-transcribed mRNA poly(A) tail shortening |
MGI:MGI:3589099 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0003676 |
nucleic acid binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003729 |
mRNA binding |
MGI:MGI:1859531 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003729 |
mRNA binding |
MGI:MGI:2176348 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2177366 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3589099 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2177366 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3589099 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:1859531 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:1859531 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006402 |
mRNA catabolic process |
MGI:MGI:1859531 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006402 |
mRNA catabolic process |
MGI:MGI:2176348 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006402 |
mRNA catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006950 |
response to stress |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007243 |
intracellular protein kinase cascade |
MGI:MGI:73465 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0010494 |
cytoplasmic stress granule |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0017091 |
AU-rich element binding |
MGI:MGI:3589099 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0017091 |
AU-rich element binding |
MGI:MGI:4457258 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0017091 |
AU-rich element binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019957 |
C-C chemokine binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0032680 |
regulation of tumor necrosis factor production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043488 |
regulation of mRNA stability |
MGI:MGI:3511379 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045638 |
negative regulation of myeloid cell differentiation |
MGI:MGI:2152007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652418 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:2152007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652418 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:5301204 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:81466 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652418 |
P |
From MGI |
||
| GO:0050779 |
RNA destabilization |
MGI:MGI:2152007 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2652418 |
P |
From MGI |
||
| GO:0060213 |
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070935 |
3'-UTR-mediated mRNA stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071889 |
14-3-3 protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Kang JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J Immunol 187: 2696-701 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Blackshear PJ et al. (2005) Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biol Reprod 73: 297-307 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Lai WS et al. (2000) Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J Biol Chem 275: 17827-37 PubMed GONUTS page
- ↑ 4.0 4.1 Lai WS et al. (2002) Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem 277: 9606-13 PubMed GONUTS page
- ↑ 5.0 5.1 Phillips RS et al. (2002) Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem 277: 11606-13 PubMed GONUTS page
- ↑ Taylor GA et al. (1995) Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J Biol Chem 270: 13341-7 PubMed GONUTS page
- ↑ Lai WS et al. (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 19: 4311-23 PubMed GONUTS page
- ↑ Ciais D et al. (2004) Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene 23: 8673-80 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Carballo E & Blackshear PJ (2001) Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-95 PubMed GONUTS page
- ↑ Taylor GA et al. (1996) A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4: 445-54 PubMed GONUTS page
