GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Zap70
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Zap70 ( synonyms: Srk, TZK, ZAP-70 ) | |
| Protein Name(s) | zeta-chain (TCR) associated protein kinase, | |
| External Links | ||
| MGI | MGI:99613 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001772 |
immunological synapse |
MGI:MGI:3686961 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001784 |
phosphotyrosine binding |
MGI:MGI:66781 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0004672 |
protein kinase activity |
MGI:MGI:3041371 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:82860 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:892668 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
F |
From MGI |
||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3686961 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:82860 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:3686961 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:892833 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3686961 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:892668 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:82860 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0018108 |
peptidyl-tyrosine phosphorylation |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
P |
From MGI |
||
| GO:0035556 |
intracellular signal transduction |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0042101 |
T cell receptor complex |
MGI:MGI:66058 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043366 |
beta selection |
MGI:MGI:1096306 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99515 |
P |
From MGI |
||
| GO:0045059 |
positive thymic T cell selection |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045059 |
positive thymic T cell selection |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0045060 |
negative thymic T cell selection |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0045061 |
thymic T cell selection |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0045582 |
positive regulation of T cell differentiation |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045582 |
positive regulation of T cell differentiation |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:1096306 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99515 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0046638 |
positive regulation of alpha-beta T cell differentiation |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
P |
From MGI |
||
| GO:0046641 |
positive regulation of alpha-beta T cell proliferation |
MGI:MGI:1096306 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99515 |
P |
From MGI |
||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:82860 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
P |
From MGI |
||
| GO:0050850 |
positive regulation of calcium-mediated signaling |
MGI:MGI:75253 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2677447 |
P |
From MGI |
||
| GO:0050850 |
positive regulation of calcium-mediated signaling |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
P |
From MGI |
||
| GO:0050852 |
T cell receptor signaling pathway |
MGI:MGI:893249 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526403 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Gu Y et al. (2006) RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nat Immunol 7: 1182-90 PubMed GONUTS page
- ↑ Gauen LK et al. (1994) Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol 14: 3729-41 PubMed GONUTS page
- ↑ Carpino N et al. (2004) Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity 20: 37-46 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Latour S et al. (1996) Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem 271: 22782-90 PubMed GONUTS page
- ↑ 5.0 5.1 Takaki S et al. (1997) Characterization of Lnk. An adaptor protein expressed in lymphocytes. J Biol Chem 272: 14562-70 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Wiest DL et al. (1997) A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Immunity 6: 663-71 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Negishi I et al. (1995) Essential role for ZAP-70 in both positive and negative selection of thymocytes. Nature 376: 435-8 PubMed GONUTS page
- ↑ Hatakeyama S et al. (1997) Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem 272: 15085-92 PubMed GONUTS page
- ↑ Chan AC et al. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol 152: 4758-66 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Cheng AM et al. (1997) The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc Natl Acad Sci U S A 94: 9797-801 PubMed GONUTS page
