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MGI:Xcl1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Xcl1 ( synonyms: ATAC, Lptn, LTN, lymphotactin, SCM-1, SCM-1a, Scyc1 ) | |
| Protein Name(s) | chemokine (C motif) ligand 1, | |
| External Links | ||
| MGI | MGI:104593 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002426 |
immunoglobulin production in mucosal tissue |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002690 |
positive regulation of leukocyte chemotaxis |
MGI:MGI:77040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002725 |
negative regulation of T cell cytokine production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002726 |
positive regulation of T cell cytokine production |
MGI:MGI:85636 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0002839 |
positive regulation of immune response to tumor cell |
MGI:MGI:5009208 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0202 |
F |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006935 |
chemotaxis |
MGI:MGI:1344950 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008009 |
chemokine activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008009 |
chemokine activity |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008009 |
chemokine activity |
MGI:MGI:77040 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0009615 |
response to virus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010820 |
positive regulation of T cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010820 |
positive regulation of T cell chemotaxis |
MGI:MGI:5009212 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010820 |
positive regulation of T cell chemotaxis |
MGI:MGI:85636 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032689 |
negative regulation of interferon-gamma production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032703 |
negative regulation of interleukin-2 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032733 |
positive regulation of interleukin-10 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035744 |
T-helper 1 cell cytokine production |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035745 |
T-helper 2 cell cytokine production |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035782 |
mature natural killer cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042104 |
positive regulation of activated T cell proliferation |
MGI:MGI:5009207 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042379 |
chemokine receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042379 |
chemokine receptor binding |
MGI:MGI:5009209 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042379 |
chemokine receptor binding |
MGI:MGI:5009353 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045089 |
positive regulation of innate immune response |
MGI:MGI:85636 |
IC: Inferred by Curator |
GO:2000503 |
P |
From MGI |
||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048247 |
lymphocyte chemotaxis |
MGI:MGI:85636 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050727 |
regulation of inflammatory response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050727 |
regulation of inflammatory response |
MGI:MGI:5009193 |
IC: Inferred by Curator |
GO:0090023 |
P |
From MGI |
||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
MGI:MGI:1344950 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
MGI:MGI:77040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0051281 |
positive regulation of release of sequestered calcium ion into cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071353 |
cellular response to interleukin-4 |
MGI:MGI:85739 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071560 |
cellular response to transforming growth factor beta stimulus |
MGI:MGI:85739 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071636 |
positive regulation of transforming growth factor beta production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071663 |
positive regulation of granzyme B production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090023 |
positive regulation of neutrophil chemotaxis |
MGI:MGI:5009193 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000412 |
positive regulation of thymocyte migration |
MGI:MGI:77040 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000503 |
positive regulation of natural killer cell chemotaxis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000513 |
positive regulation of granzyme A production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000518 |
negative regulation of T-helper 1 cell activation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000538 |
positive regulation of B cell chemotaxis |
MGI:MGI:5009193 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000562 |
negative regulation of CD4-positive, alpha-beta T cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000566 |
positive regulation of CD8-positive, alpha-beta T cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Lillard JW Jr et al. (1999) Lymphotactin acts as an innate mucosal adjuvant. J Immunol 162: 1959-65 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Kelner GS et al. (1994) Lymphotactin: a cytokine that represents a new class of chemokine. Science 266: 1395-9 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Hedrick JA et al. (1997) Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. J Immunol 158: 1533-40 PubMed GONUTS page
- ↑ Cao X et al. (1998) Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity. J Immunol 161: 6238-44 PubMed GONUTS page
- ↑ 5.0 5.1 Yoshida T et al. (1999) Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. FEBS Lett 458: 37-40 PubMed GONUTS page
- ↑ Boismenu R et al. (1996) Chemokine expression by intraepithelial gamma delta T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J Immunol 157: 985-92 PubMed GONUTS page
- ↑ Yoshida T et al. (1998) Identification of single C motif-1/lymphotactin receptor XCR1. J Biol Chem 273: 16551-4 PubMed GONUTS page
- ↑ Yamazaki C et al. (2010) Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice. Biochem Biophys Res Commun 397: 756-61 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Huang H et al. (2001) Neutrophils and B cells express XCR1 receptor and chemotactically respond to lymphotactin. Biochem Biophys Res Commun 281: 378-82 PubMed GONUTS page
- ↑ 10.0 10.1 Rumsaeng V et al. (1997) Lymphotactin gene expression in mast cells following Fc(epsilon) receptor I aggregation: modulation by TGF-beta, IL-4, dexamethasone, and cyclosporin A. J Immunol 158: 1353-60 PubMed GONUTS page
