MGI:Wt1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:77690 PMID:7585606^[1]	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:5284812 PMID:12609742^[2]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	MGI:MGI:5306737 PMID:21719793^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:3607478 PMID:16264195^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268	P	From MGI
	GO:0001656	metanephros development	MGI:MGI:1335967 PMID:10322633^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268 MGI:MGI:2183642	P	From MGI
	GO:0001656	metanephros development	MGI:MGI:2149238 PMID:11509181^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183640	P	From MGI
	GO:0001656	metanephros development	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001657	ureteric bud development	MGI:MGI:1335967 PMID:10322633^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0001822	kidney development	MGI:MGI:3699551 PMID:11912180^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001822	kidney development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0001823	mesonephros development	MGI:MGI:87728 PMID:9118800^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268	P	From MGI
	GO:0003156	regulation of organ formation	MGI:MGI:3790398 PMID:17537799^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003676	nucleic acid binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR013087	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From MGI
	GO:0003690	double-stranded DNA binding	MGI:MGI:77690 PMID:7585606^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4413553 PMID:8530339^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003723	RNA binding	MGI:MGI:3032819 PMID:14681305^[13]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003723	RNA binding	MGI:MGI:3032819 PMID:14681305^[13]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005515	protein binding	MGI:MGI:3790398 PMID:17537799^[11]	IPI: Inferred from Physical Interaction	UniProtKB:O35740	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4418604 PMID:19050011^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q91XV3	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4418642 PMID:9784496^[15]	IPI: Inferred from Physical Interaction	UniProtKB:P26369	F	From MGI
	GO:0005622	intracellular	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR007087 InterPro:IPR015880	C	From MGI
	GO:0005634	nucleus	MGI:MGI:3777066 PMID:16467207^[16]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P49952	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4418604 PMID:19050011^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4419083 PMID:14701728^[17]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5284812 PMID:12609742^[2]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2686777 PMID:14678822^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3032819 PMID:14681305^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:3032819 PMID:14681305^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2176638 PMID:11889045^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:2384274 PMID:12151099^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0007281	germ cell development	MGI:MGI:3051942 PMID:15063178^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268	P	From MGI
	GO:0007356	thorax and anterior abdomen determination	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007507	heart development	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007507	heart development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0007530	sex determination	MGI:MGI:2149238 PMID:11509181^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183642	P	From MGI
	GO:0007530	sex determination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0008380	RNA splicing	MGI:MGI:4418642 PMID:9784496^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008406	gonad development	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0008584	male gonad development	MGI:MGI:3051942 PMID:15063178^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:3851651 PMID:19457926^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:1306784	P	From MGI
	GO:0009888	tissue development	MGI:MGI:3574744 PMID:15716344^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183640	P	From MGI
	GO:0016607	nuclear speck	MGI:MGI:4418642 PMID:9784496^[15]	TAS: Traceable Author Statement		C	From MGI
	GO:0016607	nuclear speck	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	C	From MGI
	GO:0017148	negative regulation of translation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0030325	adrenal gland development	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030325	adrenal gland development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0030539	male genitalia development	MGI:MGI:1332959 PMID:10077614^[24]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030855	epithelial cell differentiation	MGI:MGI:1330701 PMID:9927198^[25]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032835	glomerulus development	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032835	glomerulus development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0032836	glomerular basement membrane development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0035802	adrenal cortex formation	MGI:MGI:3790398 PMID:17537799^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043010	camera-type eye development	MGI:MGI:2176638 PMID:11889045^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857268	P	From MGI
	GO:0043010	camera-type eye development	MGI:MGI:3574744 PMID:15716344^[23]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183642	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4412470 PMID:8119964^[26]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P19544	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P49952	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	F	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4412470 PMID:8119964^[26]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P19544	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4413553 PMID:8530339^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4419083 PMID:14701728^[17]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P19544	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1330701 PMID:9927198^[25]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3699551 PMID:11912180^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3790398 PMID:17537799^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3839158 PMID:19301398^[27]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4413553 PMID:8530339^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P49952	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3607478 PMID:16264195^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3607478 PMID:16264195^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P49952	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5306737 PMID:21719793^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0060231	mesenchymal to epithelial transition	MGI:MGI:1330701 PMID:9927198^[25]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060231	mesenchymal to epithelial transition	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060421	positive regulation of heart growth	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060539	diaphragm development	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060923	cardiac muscle cell fate commitment	MGI:MGI:5285454 PMID:21654746^[28]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060976	coronary vasculature development	MGI:MGI:4943617 PMID:20299672^[29]	TAS: Traceable Author Statement		P	From MGI
	GO:0061032	visceral serous pericardium development	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061032	visceral serous pericardium development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0061032	visceral serous pericardium development	MGI:MGI:4943617 PMID:20299672^[29]	TAS: Traceable Author Statement		P	From MGI
	GO:0070742	C2H2 zinc finger domain binding	MGI:MGI:4412470 PMID:8119964^[26]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P19544	F	From MGI
	GO:0070742	C2H2 zinc finger domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	F	From MGI
	GO:0071371	cellular response to gonadotropin stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0072075	metanephric mesenchyme development	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072112	glomerular visceral epithelial cell differentiation	MGI:MGI:4418604 PMID:19050011^[14]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0072166	posterior mesonephric tubule development	MGI:MGI:87728 PMID:9118800^[10]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072284	metanephric S-shaped body morphogenesis	MGI:MGI:1333093 PMID:10101119^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072284	metanephric S-shaped body morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P19544	P	From MGI
	GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	MGI:MGI:1332959 PMID:10077614^[24]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000020	positive regulation of male gonad development	MGI:MGI:3839158 PMID:19301398^[27]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000195	negative regulation of female gonad development	MGI:MGI:3839158 PMID:19301398^[27]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2001076	positive regulation of metanephric ureteric bud development	MGI:MGI:62488 PMID:8395349^[7]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hewitt SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55: 5386-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Wagner KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305: 217-23 PubMed GONUTS page
↑ ^3.0 ^3.1 Schumacher VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol 22: 1286-96 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Wagner N et al. (2005) Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev 19: 2631-42 PubMed GONUTS page
↑ ^5.0 ^5.1 Donovan MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet 24: 252-62 PubMed GONUTS page
↑ ^6.0 ^6.1 Hammes A et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106: 319-29 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Kreidberg JA et al. (1993) WT-1 is required for early kidney development. Cell 74: 679-91 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Moore AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-57 PubMed GONUTS page
↑ ^9.0 ^9.1 Guo JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11: 651-9 PubMed GONUTS page
↑ ^10.0 ^10.1 Sainio K et al. (1997) Differential regulation of two sets of mesonephric tubules by WT-1. Development 124: 1293-9 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Val P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134: 2349-58 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Cohen JS (1995) Provide fluoxetine information vital to clinicians. J Clin Psychiatry 56: 591 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Niksic M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet 13: 463-71 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Green LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res 37: 431-40 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Davies RC et al. (1998) WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev 12: 3217-25 PubMed GONUTS page
↑ Dame C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107: 4282-90 PubMed GONUTS page
↑ ^17.0 ^17.1 Carpenter B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol Cell Biol 24: 537-49 PubMed GONUTS page
↑ Clipsham R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr Patterns 4: 3-14 PubMed GONUTS page
↑ ^19.0 ^19.1 Wagner KD et al. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J 21: 1398-405 PubMed GONUTS page
↑ Du X et al. (2002) The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochim Biophys Acta 1577: 93-101 PubMed GONUTS page
↑ ^21.0 ^21.1 Natoli TA et al. (2004) Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol 268: 429-40 PubMed GONUTS page
↑ Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet 18: 2989-3001 PubMed GONUTS page
↑ ^23.0 ^23.1 Wagner N et al. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development 132: 1327-36 PubMed GONUTS page
↑ ^24.0 ^24.1 Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A 96: 2931-6 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Hosono S et al. (1999) WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene 18: 417-27 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Rupprecht HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269: 6198-206 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Lee HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn 238: 812-25 PubMed GONUTS page
↑ Smart N et al. (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature 474: 640-4 PubMed GONUTS page
↑ ^29.0 ^29.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:7585606-0] 1.0 ^1.1 Hewitt SM et al. (1995) Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 55: 5386-9 PubMed GONUTS page

[PMID:12609742-1] 2.0 ^2.1 Wagner KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene 305: 217-23 PubMed GONUTS page

[PMID:21719793-2] 3.0 ^3.1 Schumacher VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol 22: 1286-96 PubMed GONUTS page

[PMID:16264195-3] 4.0 ^4.1 ^4.2 Wagner N et al. (2005) Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Genes Dev 19: 2631-42 PubMed GONUTS page

[PMID:10322633-4] 5.0 ^5.1 Donovan MJ et al. (1999) Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet 24: 252-62 PubMed GONUTS page

[PMID:11509181-5] 6.0 ^6.1 Hammes A et al. (2001) Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell 106: 319-29 PubMed GONUTS page

[PMID:8395349-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Kreidberg JA et al. (1993) WT-1 is required for early kidney development. Cell 74: 679-91 PubMed GONUTS page

[PMID:10101119-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Moore AW et al. (1999) YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 126: 1845-57 PubMed GONUTS page

[PMID:11912180-8] 9.0 ^9.1 Guo JK et al. (2002) WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet 11: 651-9 PubMed GONUTS page

[PMID:9118800-9] 10.0 ^10.1 Sainio K et al. (1997) Differential regulation of two sets of mesonephric tubules by WT-1. Development 124: 1293-9 PubMed GONUTS page

[PMID:17537799-10] 11.0 ^11.1 ^11.2 ^11.3 Val P et al. (2007) Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134: 2349-58 PubMed GONUTS page

[PMID:8530339-11] 12.0 ^12.1 ^12.2 Cohen JS (1995) Provide fluoxetine information vital to clinicians. J Clin Psychiatry 56: 591 PubMed GONUTS page

[PMID:14681305-12] 13.0 ^13.1 ^13.2 ^13.3 Niksic M et al. (2004) The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes. Hum Mol Genet 13: 463-71 PubMed GONUTS page

[PMID:19050011-13] 14.0 ^14.1 ^14.2 Green LM et al. (2009) Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res 37: 431-40 PubMed GONUTS page

[PMID:9784496-14] 15.0 ^15.1 ^15.2 Davies RC et al. (1998) WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes. Genes Dev 12: 3217-25 PubMed GONUTS page

[PMID:16467207-15] Dame C et al. (2006) Wilms tumor suppressor, Wt1, is a transcriptional activator of the erythropoietin gene. Blood 107: 4282-90 PubMed GONUTS page

[PMID:14701728-16] 17.0 ^17.1 Carpenter B et al. (2004) BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1. Mol Cell Biol 24: 537-49 PubMed GONUTS page

[PMID:14678822-17] Clipsham R et al. (2004) Nr0b1 and its network partners are expressed early in murine embryos prior to steroidogenic axis organogenesis. Gene Expr Patterns 4: 3-14 PubMed GONUTS page

[PMID:11889045-18] 19.0 ^19.1 Wagner KD et al. (2002) The Wilms' tumor gene Wt1 is required for normal development of the retina. EMBO J 21: 1398-405 PubMed GONUTS page

[PMID:12151099-19] Du X et al. (2002) The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation. Biochim Biophys Acta 1577: 93-101 PubMed GONUTS page

[PMID:15063178-20] 21.0 ^21.1 Natoli TA et al. (2004) Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol 268: 429-40 PubMed GONUTS page

[PMID:19457926-21] Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet 18: 2989-3001 PubMed GONUTS page

[PMID:15716344-22] 23.0 ^23.1 Wagner N et al. (2005) A splice variant of the Wilms' tumour suppressor Wt1 is required for normal development of the olfactory system. Development 132: 1327-36 PubMed GONUTS page

[PMID:10077614-23] 24.0 ^24.1 Patek CE et al. (1999) A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A 96: 2931-6 PubMed GONUTS page

[PMID:9927198-24] 25.0 ^25.1 ^25.2 Hosono S et al. (1999) WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts. Oncogene 18: 417-27 PubMed GONUTS page

[PMID:8119964-25] 26.0 ^26.1 ^26.2 Rupprecht HD et al. (1994) The Wilms' tumor suppressor gene WT1 is negatively autoregulated. J Biol Chem 269: 6198-206 PubMed GONUTS page

[PMID:19301398-26] 27.0 ^27.1 ^27.2 Lee HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn 238: 812-25 PubMed GONUTS page

[PMID:21654746-27] Smart N et al. (2011) De novo cardiomyocytes from within the activated adult heart after injury. Nature 474: 640-4 PubMed GONUTS page

[PMID:20299672-28] 29.0 ^29.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Wt1 ( synonyms: Wt-1 )
Protein Name(s)	Wilms tumor 1 homolog,
External Links
MGI	MGI:98968

MGI:Wt1

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