MGI:Wnt4

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0001656	metanephros development	MGI:MGI:1327700 PMID:9889131^[1]	TAS: Traceable Author Statement		P	From MGI
	GO:0001656	metanephros development	MGI:MGI:69785 PMID:7990960^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0001658	branching involved in ureteric bud morphogenesis	MGI:MGI:3588895 PMID:16054034^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001823	mesonephros development	MGI:MGI:3777712 PMID:14695376^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001838	embryonic epithelial tube formation	MGI:MGI:3624584 PMID:16546160^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0003714	transcription corepressor activity	MGI:MGI:2675528 PMID:12949260^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005102	receptor binding	MGI:MGI:1327700 PMID:9889131^[1]	TAS: Traceable Author Statement		F	From MGI
	GO:0005109	frizzled binding	MGI:MGI:4835152 PMID:15265686^[7]	IPI: Inferred from Physical Interaction	UniProtKB:Q61089	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1314989 PMID:9853965^[8]	IPI: Inferred from Physical Interaction	UniProtKB:P97299	F	From MGI
	GO:0005515	protein binding	MGI:MGI:1860653 PMID:10866835^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q9CWT0	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2178168 PMID:11956231^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q91VN0	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3718804 PMID:17690294^[11]	IPI: Inferred from Physical Interaction	UniProtKB:O35082	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005817 InterPro:IPR009142	C	From MGI
	GO:0005578	proteinaceous extracellular matrix	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0272	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4459044		PANTHER:PTHR12027	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445854	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_445854	C	From MGI
	GO:0005794	Golgi apparatus	MGI:MGI:4459044		PANTHER:PTHR12027	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4459044		PANTHER:PTHR12027	C	From MGI
	GO:0006702	androgen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1327700 PMID:9889131^[1]	TAS: Traceable Author Statement		P	From MGI
	GO:0007267	cell-cell signaling	MGI:MGI:1327700 PMID:9889131^[1]	TAS: Traceable Author Statement		P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005817 InterPro:IPR009142	P	From MGI
	GO:0007276	gamete generation	MGI:MGI:3042808 PMID:15162500^[12]	IGI: Inferred from Genetic Interaction	MGI:MGI:95586	P	From MGI
	GO:0007492	endoderm development	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0007548	sex differentiation	MGI:MGI:1329753 PMID:9989404^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:3618017 PMID:15581876^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:4821086 PMID:11283799^[15]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56705	P	From MGI
	GO:0008584	male gonad development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0008585	female gonad development	MGI:MGI:3042808 PMID:15162500^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0008585	female gonad development	MGI:MGI:4398804 PMID:19830824^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4399122	P	From MGI
	GO:0008585	female gonad development	MGI:MGI:4438994 PMID:20106871^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0008585	female gonad development	MGI:MGI:4821939 PMID:17976063^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0009798	axis specification	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0009952	anterior/posterior pattern specification	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0009986	cell surface	MGI:MGI:66576 PMID:8167409^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:2178881 PMID:11948913^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0010894	negative regulation of steroid biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0879	P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005817 InterPro:IPR009142	P	From MGI
	GO:0018345	protein palmitoylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0022407	regulation of cell-cell adhesion	MGI:MGI:4438994 PMID:20106871^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0030154	cell differentiation	MGI:MGI:3618017 PMID:15581876^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0030237	female sex determination	MGI:MGI:4821086 PMID:11283799^[15]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56705	P	From MGI
	GO:0030237	female sex determination	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0030501	positive regulation of bone mineralization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0031012	extracellular matrix	MGI:MGI:66576 PMID:8167409^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0032349	positive regulation of aldosterone biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0033077	T cell differentiation in thymus	MGI:MGI:1929591 PMID:11265645^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0033080	immature T cell proliferation in thymus	MGI:MGI:3803049 PMID:18617424^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0035239	tube morphogenesis	MGI:MGI:3624584 PMID:16546160^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0035567	non-canonical Wnt receptor signaling pathway	MGI:MGI:3803049 PMID:18617424^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0038030	non-canonical Wnt receptor signaling pathway via MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	MGI:MGI:3639791 PMID:16700629^[23]	IGI: Inferred from Genetic Interaction	MGI:MGI:104723	P	From MGI
	GO:0042445	hormone metabolic process	MGI:MGI:2445852 PMID:12399432^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4454604 PMID:20454446^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:88276 MGI:MGI:96571	P	From MGI
	GO:0045165	cell fate commitment	MGI:MGI:3777488 PMID:18351662^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0045596	negative regulation of cell differentiation	MGI:MGI:3618017 PMID:15581876^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0045836	positive regulation of meiosis	MGI:MGI:4438994 PMID:20106871^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:98958	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:2675528 PMID:12949260^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:2675528 PMID:12949260^[6]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56705	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:3839158 PMID:19301398^[27]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:1099602 PMID:9356179^[28]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3839158 PMID:19301398^[27]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4821086 PMID:11283799^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0048599	oocyte development	MGI:MGI:1329753 PMID:9989404^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0048599	oocyte development	MGI:MGI:4454604 PMID:20454446^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:88276 MGI:MGI:96571	P	From MGI
	GO:0048754	branching morphogenesis of a tube	MGI:MGI:2178881 PMID:11948913^[20]	IGI: Inferred from Genetic Interaction	UniProtKB:P22727	P	From MGI
	GO:0048856	anatomical structure development	MGI:MGI:3701031 PMID:16818445^[29]	IGI: Inferred from Genetic Interaction	MGI:MGI:2446084	P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:3624584 PMID:16546160^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051145	smooth muscle cell differentiation	MGI:MGI:3624584 PMID:16546160^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:1929591 PMID:11265645^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4454604 PMID:20454446^[25]	IGI: Inferred from Genetic Interaction	MGI:MGI:88276	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4835152 PMID:15265686^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060126	somatotropin secreting cell differentiation	MGI:MGI:3777488 PMID:18351662^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation	MGI:MGI:3777488 PMID:18351662^[26]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0060231	mesenchymal to epithelial transition	MGI:MGI:69785 PMID:7990960^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis	MGI:MGI:1354852 PMID:10733525^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857453	P	From MGI
	GO:0061184	positive regulation of dermatome development	MGI:MGI:1349347 PMID:10654605^[31]	ISS: Inferred from Sequence or Structural Similarity	UniProtKB:P56705	P	From MGI
	GO:0061184	positive regulation of dermatome development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0061205	paramesonephric duct development	MGI:MGI:3777712 PMID:14695376^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061205	paramesonephric duct development	MGI:MGI:4398804 PMID:19830824^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4399122	P	From MGI
	GO:0061205	paramesonephric duct development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0061369	negative regulation of testicular blood vessel morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0072033	renal vesicle formation	MGI:MGI:3588895 PMID:16054034^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0072034	renal vesicle induction	MGI:MGI:2150217 PMID:11507767^[32]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0072162	metanephric mesenchymal cell differentiation	MGI:MGI:3663200 PMID:16368682^[33]	NAS: Non-traceable Author Statement		P	From MGI
	GO:0072164	mesonephric tubule development	MGI:MGI:4430439 PMID:20040500^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:98505	P	From MGI
	GO:0072273	metanephric nephron morphogenesis	MGI:MGI:4398804 PMID:19830824^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4399122	P	From MGI
	GO:0090002	establishment of protein localization in plasma membrane	MGI:MGI:4821939 PMID:17976063^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090002	establishment of protein localization in plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:2000019	negative regulation of male gonad development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:2000066	positive regulation of cortisol biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
	GO:2000225	negative regulation of testosterone biosynthetic process	MGI:MGI:2675528 PMID:12949260^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:2000225	negative regulation of testosterone biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P56705	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page
↑ ^2.0 ^2.1 Stark K et al. (1994) Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372: 679-83 PubMed GONUTS page
↑ ^3.0 ^3.1 Carroll TJ et al. (2005) Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9: 283-92 PubMed GONUTS page
↑ ^4.0 ^4.1 Kobayashi A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development 131: 539-49 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Itäranta P et al. (2006) Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney. Dev Biol 293: 473-83 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Jordan BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A 100: 10866-71 PubMed GONUTS page
↑ ^7.0 ^7.1 Lyons JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp Cell Res 298: 369-87 PubMed GONUTS page
↑ Lescher B et al. (1998) sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn 213: 440-51 PubMed GONUTS page
↑ Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem 267: 4300-11 PubMed GONUTS page
↑ Kato M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157: 303-14 PubMed GONUTS page
↑ Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-6 PubMed GONUTS page
↑ ^12.0 ^12.1 Yao HH et al. (2004) Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn 230: 210-5 PubMed GONUTS page
↑ ^13.0 ^13.1 Vainio S et al. (1999) Female development in mammals is regulated by Wnt-4 signalling. Nature 397: 405-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Jeays-Ward K et al. (2004) Wnt4 is required for proper male as well as female sexual development. Dev Biol 276: 431-40 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Jordan BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet 68: 1102-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Shan J et al. (2009) Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. Genesis 47: 782-8 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Naillat F et al. (2010) Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet 19: 1539-50 PubMed GONUTS page
↑ ^18.0 ^18.1 Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page
↑ ^19.0 ^19.1 Smolich BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell 4: 1267-75 PubMed GONUTS page
↑ ^20.0 ^20.1 Itäranta P et al. (2002) Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis 32: 259-68 PubMed GONUTS page
↑ ^21.0 ^21.1 Staal FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol 31: 285-93 PubMed GONUTS page
↑ ^22.0 ^22.1 Louis I et al. (2008) The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling. Immunity 29: 57-67 PubMed GONUTS page
↑ Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4: e187 PubMed GONUTS page
↑ Heikkilä M et al. (2002) Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Endocrinology 143: 4358-65 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Liu CF et al. (2010) WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One 5: e10382 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Potok MA et al. (2008) WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn 237: 1006-20 PubMed GONUTS page
↑ ^27.0 ^27.1 Lee HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn 238: 812-25 PubMed GONUTS page
↑ Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol 191: 160-5 PubMed GONUTS page
↑ Später D et al. (2006) Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development 133: 3039-49 PubMed GONUTS page
↑ Brisken C et al. (2000) Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 14: 650-4 PubMed GONUTS page
↑ Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page
↑ Lin Y et al. (2001) Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn 222: 26-39 PubMed GONUTS page
↑ Torban E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem 281: 12705-12 PubMed GONUTS page
↑ Lokmane L et al. (2010) vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development 137: 347-57 PubMed GONUTS page

[PMID:9889131-0] 1.0 ^1.1 ^1.2 ^1.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page

[PMID:7990960-1] 2.0 ^2.1 Stark K et al. (1994) Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372: 679-83 PubMed GONUTS page

[PMID:16054034-2] 3.0 ^3.1 Carroll TJ et al. (2005) Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 9: 283-92 PubMed GONUTS page

[PMID:14695376-3] 4.0 ^4.1 Kobayashi A et al. (2004) Requirement of Lim1 for female reproductive tract development. Development 131: 539-49 PubMed GONUTS page

[PMID:16546160-4] 5.0 ^5.1 ^5.2 ^5.3 Itäranta P et al. (2006) Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney. Dev Biol 293: 473-83 PubMed GONUTS page

[PMID:12949260-5] 6.0 ^6.1 ^6.2 ^6.3 Jordan BK et al. (2003) Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy. Proc Natl Acad Sci U S A 100: 10866-71 PubMed GONUTS page

[PMID:15265686-6] 7.0 ^7.1 Lyons JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp Cell Res 298: 369-87 PubMed GONUTS page

[PMID:9853965-7] Lescher B et al. (1998) sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn 213: 440-51 PubMed GONUTS page

[PMID:10866835-8] Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem 267: 4300-11 PubMed GONUTS page

[PMID:11956231-9] Kato M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol 157: 303-14 PubMed GONUTS page

[PMID:17690294-10] Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-6 PubMed GONUTS page

[PMID:15162500-11] 12.0 ^12.1 Yao HH et al. (2004) Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn 230: 210-5 PubMed GONUTS page

[PMID:9989404-12] 13.0 ^13.1 Vainio S et al. (1999) Female development in mammals is regulated by Wnt-4 signalling. Nature 397: 405-9 PubMed GONUTS page

[PMID:15581876-13] 14.0 ^14.1 ^14.2 Jeays-Ward K et al. (2004) Wnt4 is required for proper male as well as female sexual development. Dev Biol 276: 431-40 PubMed GONUTS page

[PMID:11283799-14] 15.0 ^15.1 ^15.2 Jordan BK et al. (2001) Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans. Am J Hum Genet 68: 1102-9 PubMed GONUTS page

[PMID:19830824-15] 16.0 ^16.1 ^16.2 Shan J et al. (2009) Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse. Genesis 47: 782-8 PubMed GONUTS page

[PMID:20106871-16] 17.0 ^17.1 ^17.2 Naillat F et al. (2010) Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet 19: 1539-50 PubMed GONUTS page

[PMID:17976063-17] 18.0 ^18.1 Kelly JM et al. (2007) Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim 42: 577-82 PubMed GONUTS page

[PMID:8167409-18] 19.0 ^19.1 Smolich BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell 4: 1267-75 PubMed GONUTS page

[PMID:11948913-19] 20.0 ^20.1 Itäranta P et al. (2002) Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro. Genesis 32: 259-68 PubMed GONUTS page

[PMID:11265645-20] 21.0 ^21.1 Staal FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol 31: 285-93 PubMed GONUTS page

[PMID:18617424-21] 22.0 ^22.1 Louis I et al. (2008) The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling. Immunity 29: 57-67 PubMed GONUTS page

[PMID:16700629-22] Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol 4: e187 PubMed GONUTS page

[PMID:12399432-23] Heikkilä M et al. (2002) Wnt-4 deficiency alters mouse adrenal cortex function, reducing aldosterone production. Endocrinology 143: 4358-65 PubMed GONUTS page

[PMID:20454446-24] 25.0 ^25.1 ^25.2 Liu CF et al. (2010) WNT4/beta-catenin pathway maintains female germ cell survival by inhibiting activin betaB in the mouse fetal ovary. PLoS One 5: e10382 PubMed GONUTS page

[PMID:18351662-25] 26.0 ^26.1 ^26.2 Potok MA et al. (2008) WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn 237: 1006-20 PubMed GONUTS page

[PMID:19301398-26] 27.0 ^27.1 Lee HJ et al. (2009) Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn 238: 812-25 PubMed GONUTS page

[PMID:9356179-27] Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol 191: 160-5 PubMed GONUTS page

[PMID:16818445-28] Später D et al. (2006) Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development 133: 3039-49 PubMed GONUTS page

[PMID:10733525-29] Brisken C et al. (2000) Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev 14: 650-4 PubMed GONUTS page

[PMID:10654605-30] Lee CS et al. (2000) SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm. Development 127: 109-18 PubMed GONUTS page

[PMID:11507767-31] Lin Y et al. (2001) Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn 222: 26-39 PubMed GONUTS page

[PMID:16368682-32] Torban E et al. (2006) PAX2 activates WNT4 expression during mammalian kidney development. J Biol Chem 281: 12705-12 PubMed GONUTS page

[PMID:20040500-33] Lokmane L et al. (2010) vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis. Development 137: 347-57 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Wnt4 ( synonyms: Wnt-4 )
Protein Name(s)	wingless-related MMTV integration site 4,
External Links
MGI	MGI:98957

MGI:Wnt4

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