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MGI:Wnt3a
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Wnt3a ( synonyms: Wnt-3a ) | |
| Protein Name(s) | wingless-related MMTV integration site 3A, | |
| External Links | ||
| MGI | MGI:98956 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3620470 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88613 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:53909 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857088 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:3037351 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857088 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:3611726 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:64780 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001947 |
heart looping |
MGI:MGI:3611726 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0002092 |
positive regulation of receptor internalization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003136 |
negative regulation of heart induction by canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003713 |
transcription coactivator activity |
MGI:MGI:4835142 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005109 |
frizzled binding |
MGI:MGI:3814781 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005110 |
frizzled-2 binding |
MGI:MGI:4420746 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1860653 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3711396 |
IPI: Inferred from Physical Interaction |
UniProtKB:P97401 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3814781 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4839454 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:3510085 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4839454 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005769 |
early endosome |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005770 |
late endosome |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007223 |
Wnt receptor signaling pathway, calcium modulating pathway |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3611726 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0007409 |
axonogenesis |
MGI:MGI:3510085 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007409 |
axonogenesis |
MGI:MGI:3510085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:101766 |
P |
From MGI |
||
| GO:0007411 |
axon guidance |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007498 |
mesoderm development |
MGI:MGI:64780 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4359548 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4835142 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009798 |
axis specification |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0009880 |
embryonic pattern specification |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3044441 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:66576 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010387 |
signalosome assembly |
MGI:MGI:4839445 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0010977 |
negative regulation of neuron projection development |
MGI:MGI:5285122 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1861366 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96770 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1891551 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:3619748 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108520 |
P |
From MGI |
||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:3510085 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0021527 |
spinal cord association neuron differentiation |
MGI:MGI:2176385 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021527 |
spinal cord association neuron differentiation |
MGI:MGI:2176385 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98953 |
P |
From MGI |
||
| GO:0021766 |
hippocampus development |
MGI:MGI:1351292 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0021846 |
cell proliferation in forebrain |
MGI:MGI:2667422 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021874 |
Wnt receptor signaling pathway involved in forebrain neuroblast division |
MGI:MGI:1351292 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0021904 |
dorsal/ventral neural tube patterning |
MGI:MGI:64780 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0030097 |
hemopoiesis |
MGI:MGI:2662628 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030168 |
platelet activation |
MGI:MGI:4398768 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030198 |
extracellular matrix organization |
MGI:MGI:3793974 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4429763 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030879 |
mammary gland development |
MGI:MGI:3578037 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030890 |
positive regulation of B cell proliferation |
MGI:MGI:1861366 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030903 |
notochord development |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0030917 |
midbrain-hindbrain boundary development |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034613 |
cellular protein localization |
MGI:MGI:3721039 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035121 |
tail morphogenesis |
MGI:MGI:64780 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0035413 |
positive regulation of catenin import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035914 |
skeletal muscle cell differentiation |
MGI:MGI:4368064 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1924828 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3582112 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98953 |
P |
From MGI |
||
| GO:0043280 |
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
MGI:MGI:3702339 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0045595 |
regulation of cell differentiation |
MGI:MGI:2662628 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045599 |
negative regulation of fat cell differentiation |
MGI:MGI:3575460 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045599 |
negative regulation of fat cell differentiation |
MGI:MGI:3763604 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045599 |
negative regulation of fat cell differentiation |
MGI:MGI:3763604 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88373 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:1099602 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4835138 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4835142 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3703823 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4368064 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1933114 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048018 |
receptor agonist activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048103 |
somatic stem cell division |
MGI:MGI:2662628 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048343 |
paraxial mesodermal cell fate commitment |
MGI:MGI:86727 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0048697 |
positive regulation of collateral sprouting in absence of injury |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048843 |
negative regulation of axon extension involved in axon guidance |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050768 |
negative regulation of neurogenesis |
MGI:MGI:2667422 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0050770 |
regulation of axonogenesis |
MGI:MGI:3806438 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:88039 |
P |
From MGI |
||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4835138 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060021 |
palate development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060026 |
convergent extension |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:1340921 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94941 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3045675 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3573812 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3575460 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3619748 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108520 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3621828 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3664518 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3711603 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3763604 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3805609 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3814781 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3835914 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3849215 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4359544 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857489 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4368064 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1924828 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4414728 |
IGI: Inferred from Genetic Interaction |
UniPRotKB:Q08463 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4420746 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4421265 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4421265 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:892032 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4456962 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4835138 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4835152 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:5009183 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060923 |
cardiac muscle cell fate commitment |
MGI:MGI:5295932 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2143322 |
P |
From MGI |
||
| GO:0061098 |
positive regulation of protein tyrosine kinase activity |
MGI:MGI:4414728 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106613 |
P |
From MGI |
||
| GO:0061184 |
positive regulation of dermatome development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070507 |
regulation of microtubule cytoskeleton organization |
MGI:MGI:3806438 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:94941 |
P |
From MGI |
||
| GO:0070527 |
platelet aggregation |
MGI:MGI:4398768 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071425 |
hemopoietic stem cell proliferation |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0090245 |
axis elongation involved in somitogenesis |
MGI:MGI:1891551 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1298218 |
P |
From MGI |
||
| GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:3772496 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2000049 |
positive regulation of cell-cell adhesion mediated by cadherin |
MGI:MGI:4459820 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000081 |
positive regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation |
MGI:MGI:4835142 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000273 |
positive regulation of receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol 26: 2955-64 PubMed GONUTS page
- ↑ Grüneberg H & Wickramaratne GA (1974) A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol 31: 207-22 PubMed GONUTS page
- ↑ Aulehla A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 4: 395-406 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Nakaya MA et al. (2005) Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132: 5425-36 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Takada S et al. (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev 8: 174-89 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Schinner S et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia 51: 147-54 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page
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