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MGI:Wnt3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Wnt3 ( synonyms: Int-4, Wnt-3 ) | |
| Protein Name(s) | wingless-related MMTV integration site 3, | |
| External Links | ||
| MGI | MGI:98955 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0000902 |
cell morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001707 |
mesoderm formation |
MGI:MGI:1341483 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178826 |
P |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005109 |
frizzled binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005110 |
frizzled-2 binding |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1860653 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3718804 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4397730 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001099185 |
C |
From MGI |
||
| GO:0005769 |
early endosome |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005770 |
late endosome |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007223 |
Wnt receptor signaling pathway, calcium modulating pathway |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007411 |
axon guidance |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0009880 |
embryonic pattern specification |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:1327700 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0009948 |
anterior/posterior axis specification |
MGI:MGI:3771246 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450902 |
P |
From MGI |
||
| GO:0009950 |
dorsal/ventral axis specification |
MGI:MGI:2450015 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450902 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:1341483 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178826 |
P |
From MGI |
||
| GO:0010628 |
positive regulation of gene expression |
MGI:MGI:4359548 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0879 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:3822212 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030917 |
midbrain-hindbrain boundary development |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:66576 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035115 |
embryonic forelimb morphogenesis |
MGI:MGI:2450015 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450902 |
P |
From MGI |
||
| GO:0035116 |
embryonic hindlimb morphogenesis |
MGI:MGI:2450015 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450902 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0044338 |
canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044339 |
canonical Wnt receptor signaling pathway involved in osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0045599 |
negative regulation of fat cell differentiation |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0048646 |
anatomical structure formation involved in morphogenesis |
MGI:MGI:1341483 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178826 |
P |
From MGI |
||
| GO:0048697 |
positive regulation of collateral sprouting in absence of injury |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048843 |
negative regulation of axon extension involved in axon guidance |
MGI:MGI:3806438 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060064 |
Spemann organizer formation at the anterior end of the primitive streak |
MGI:MGI:1341483 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2178826 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3789532 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1329040 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060173 |
limb development |
MGI:MGI:2450015 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2450902 |
P |
From MGI |
||
| GO:0060174 |
limb bud formation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060323 |
head morphogenesis |
MGI:MGI:3789532 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1329040 |
P |
From MGI |
||
| GO:0071425 |
hemopoietic stem cell proliferation |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Liu P et al. (1999) Requirement for Wnt3 in vertebrate axis formation. Nat Genet 22: 361-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page
- ↑ Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem 267: 4300-11 PubMed GONUTS page
- ↑ Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-6 PubMed GONUTS page
- ↑ Fu J et al. (2009) Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A 106: 18598-603 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Purro SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci 28: 8644-54 PubMed GONUTS page
- ↑ Barrow JR et al. (2007) Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 312: 312-20 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Barrow JR et al. (2003) Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev 17: 394-409 PubMed GONUTS page
- ↑ Cohen ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest 119: 2538-49 PubMed GONUTS page
- ↑ Lyu J et al. (2008) Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis. Dev Cell 15: 773-80 PubMed GONUTS page
- ↑ Smolich BD et al. (1993) Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell 4: 1267-75 PubMed GONUTS page
- ↑ 12.0 12.1 Lewis SL et al. (2008) Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development 135: 1791-801 PubMed GONUTS page
