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MGI:Wnt2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Wnt2 ( synonyms: Int1l1, Irp, m-irp, Mirp, Wnt-2, Wnt2a ) | |
| Protein Name(s) | wingless-related MMTV integration site 2, | |
| External Links | ||
| MGI | MGI:98954 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0001938 |
positive regulation of endothelial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001059030 |
P |
From MGI |
||
| GO:0002053 |
positive regulation of mesenchymal cell proliferation |
MGI:MGI:4360856 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005109 |
frizzled binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005110 |
frizzled-2 binding |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
F |
From MGI |
|||
| GO:0005125 |
cytokine activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005576 |
extracellular region |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0272 |
C |
From MGI |
||
| GO:0005615 |
extracellular space |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:XP_001059030 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
C |
From MGI |
|||
| GO:0007267 |
cell-cell signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009950 |
dorsal/ventral axis specification |
MGI:MGI:4459044 |
PANTHER:PTHR12027 |
P |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:1329850 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108571 |
P |
From MGI |
||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0031012 |
extracellular matrix |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4439199 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055009 |
atrial cardiac muscle tissue morphogenesis |
MGI:MGI:4439199 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0060045 |
positive regulation of cardiac muscle cell proliferation |
MGI:MGI:4439199 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:1261652 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4360856 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1261834 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4439199 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060317 |
cardiac epithelial to mesenchymal transition |
MGI:MGI:4439199 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0060492 |
lung induction |
MGI:MGI:4360856 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1261834 |
P |
From MGI |
||
| GO:0060501 |
positive regulation of epithelial cell proliferation involved in lung morphogenesis |
MGI:MGI:4360856 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:4361155 |
P |
From MGI |
||
| GO:0060716 |
labyrinthine layer blood vessel development |
MGI:MGI:84248 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2177935 |
P |
From MGI |
||
| GO:0090263 |
positive regulation of canonical Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Goss AM et al. (2009) Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 17: 290-8 PubMed GONUTS page
- ↑ Ishikawa T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128: 25-33 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Tian Y et al. (2010) Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell 18: 275-87 PubMed GONUTS page
- ↑ Bafico A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 16: 2819-25 PubMed GONUTS page
- ↑ Monkley SJ et al. (1996) Targeted disruption of the Wnt2 gene results in placentation defects. Development 122: 3343-53 PubMed GONUTS page
