MGI:Wnt10b

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000086	G2/M transition of mitotic cell cycle	MGI:MGI:3820325 PMID:19056892^[1]	IGI: Inferred from Genetic Interaction	MGI:MGI:1351663	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3574150 PMID:15728361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3581945 PMID:15673614^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001664	G-protein coupled receptor binding	MGI:MGI:4459044		PANTHER:PTHR12027	F	From MGI
	GO:0005102	receptor binding	MGI:MGI:1327700 PMID:9889131^[4]	TAS: Traceable Author Statement		F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005576	extracellular region	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005817 InterPro:IPR013302	C	From MGI
	GO:0005578	proteinaceous extracellular matrix	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0272	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4459044		PANTHER:PTHR12027	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:4459044		PANTHER:PTHR12027	C	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:3772496 PMID:18155657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006629	lipid metabolic process	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007165	signal transduction	MGI:MGI:1327700 PMID:9889131^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0007224	smoothened signaling pathway	MGI:MGI:3703195 PMID:17284610^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007267	cell-cell signaling	MGI:MGI:1327700 PMID:9889131^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR005817 InterPro:IPR013302	P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:87698 PMID:9160667^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008585	female gonad development	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0009798	axis specification	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:1327700 PMID:9889131^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0014835	myoblast cell differentiation involved in skeletal muscle regeneration	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:1329850 PMID:11092808^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:108571	P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0030501	positive regulation of bone mineralization	MGI:MGI:3574150 PMID:15728361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030858	positive regulation of epithelial cell differentiation	MGI:MGI:3772496 PMID:18155657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030917	midbrain-hindbrain boundary development	MGI:MGI:4459044		PANTHER:PTHR12027	P	From MGI
	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	MGI:MGI:3820325 PMID:19056892^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0043403	skeletal muscle tissue regeneration	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0045598	regulation of fat cell differentiation	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:2385552 PMID:12055200^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:3574150 PMID:15728361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:3758508 PMID:10937998^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:3574150 PMID:15728361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045669	positive regulation of osteoblast differentiation	MGI:MGI:4358631 PMID:19723499^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045778	positive regulation of ossification	MGI:MGI:3574150 PMID:15728361^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0045778	positive regulation of ossification	MGI:MGI:3829542 PMID:17708715^[12]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045778	positive regulation of ossification	MGI:MGI:4358631 PMID:19723499^[11]	IGI: Inferred from Genetic Interaction	MGI:MGI:98578	P	From MGI
	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1306711 PMID:9769173^[13]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3574150 PMID:15728361^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3581945 PMID:15673614^[3]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3703195 PMID:17284610^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048641	regulation of skeletal muscle tissue development	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0048741	skeletal muscle fiber development	MGI:MGI:3581945 PMID:15673614^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:3772496 PMID:18155657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050821	protein stabilization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0050909	sensory perception of taste	MGI:MGI:3703195 PMID:17284610^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:3820325 PMID:19056892^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051246	regulation of protein metabolic process	MGI:MGI:3574150 PMID:15728361^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0051246	regulation of protein metabolic process	MGI:MGI:3820325 PMID:19056892^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0051885	positive regulation of anagen	MGI:MGI:3772496 PMID:18155657^[5]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:3758508 PMID:10937998^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0060346	bone trabecula formation	MGI:MGI:3574150 PMID:15728361^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0061196	fungiform papilla development	MGI:MGI:3703195 PMID:17284610^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3582610	P	From MGI
	GO:0071310	cellular response to organic substance	MGI:MGI:2385552 PMID:12055200^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071320	cellular response to cAMP	MGI:MGI:2385552 PMID:12055200^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071374	cellular response to parathyroid hormone stimulus	MGI:MGI:4358631 PMID:19723499^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4358631 PMID:19723499^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071425	hemopoietic stem cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:O00744	P	From MGI
	GO:0071425	hemopoietic stem cell proliferation	MGI:MGI:87698 PMID:9160667^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4358631 PMID:19723499^[11]	IDA: Inferred from Direct Assay		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Bennett CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 102: 3324-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell 16: 2039-48 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Ouji Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem Biophys Res Commun 367: 299-304 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Iwatsuki K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104: 2253-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Austin TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89: 3624-35 PubMed GONUTS page
↑ Ishikawa T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128: 25-33 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem 277: 30998-1004 PubMed GONUTS page
↑ ^10.0 ^10.1 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
↑ Bennett CN et al. (2007) Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res 22: 1924-32 PubMed GONUTS page
↑ Dassule HR & McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202: 215-27 PubMed GONUTS page

[PMID:19056892-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

[PMID:15728361-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Bennett CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 102: 3324-9 PubMed GONUTS page

[PMID:15673614-2] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Vertino AM et al. (2005) Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell 16: 2039-48 PubMed GONUTS page

[PMID:9889131-3] 4.0 ^4.1 ^4.2 ^4.3 Loureiro JJ (1999) The Wnts. Curr Biol 9: R4 PubMed GONUTS page

[PMID:18155657-4] 5.0 ^5.1 ^5.2 ^5.3 Ouji Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem Biophys Res Commun 367: 299-304 PubMed GONUTS page

[PMID:17284610-5] 6.0 ^6.1 ^6.2 ^6.3 Iwatsuki K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A 104: 2253-8 PubMed GONUTS page

[PMID:9160667-6] 7.0 ^7.1 Austin TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood 89: 3624-35 PubMed GONUTS page

[PMID:11092808-7] Ishikawa T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development 128: 25-33 PubMed GONUTS page

[PMID:12055200-8] 9.0 ^9.1 ^9.2 Bennett CN et al. (2002) Regulation of Wnt signaling during adipogenesis. J Biol Chem 277: 30998-1004 PubMed GONUTS page

[PMID:10937998-9] 10.0 ^10.1 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page

[PMID:19723499-10] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page

[PMID:17708715-11] Bennett CN et al. (2007) Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res 22: 1924-32 PubMed GONUTS page

[PMID:9769173-12] Dassule HR & McMahon AP (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol 202: 215-27 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Wnt10b ( synonyms: Wnt12 )
Protein Name(s)	wingless related MMTV integration site 10b,
External Links
MGI	MGI:108061

MGI:Wnt10b

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