MGI:Vdr

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0000902	cell morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0001501	skeletal system development	MGI:MGI:894991 PMID:9241280^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1859929	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2180411 PMID:11891224^[2]	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3525928 PMID:15601870^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR001628	F	From MGI
	GO:0003707	steroid hormone receptor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR001723	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0675	F	From MGI
	GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	MGI:MGI:3512848 PMID:15322135^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005499	vitamin D binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	F	From MGI
	GO:0005515	protein binding	MGI:MGI:84614 PMID:8978696^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q64127	F	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	C	From MGI
	GO:0005720	nuclear heterochromatin	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	C	From MGI
	GO:0005792	microsome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536 InterPro:IPR001628	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:3512848 PMID:15322135^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:3512848 PMID:15322135^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006816	calcium ion transport	MGI:MGI:2153271 PMID:11687634^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183409	P	From MGI
	GO:0006874	cellular calcium ion homeostasis	MGI:MGI:894991 PMID:9241280^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1859929	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:894991 PMID:9241280^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1859929	P	From MGI
	GO:0007595	lactation	MGI:MGI:3051725 PMID:15178742^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183404	P	From MGI
	GO:0008270	zinc ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001628 InterPro:IPR013088	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0008434	vitamin D3 receptor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	F	From MGI
	GO:0008434	vitamin D3 receptor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	F	From MGI
	GO:0008624	induction of apoptosis by extracellular signals	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:894991 PMID:9241280^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1859929	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0010839	negative regulation of keratinocyte proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0010980	positive regulation of vitamin D 24-hydroxylase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0030315	T-tubule	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	C	From MGI
	GO:0043401	steroid hormone mediated signaling pathway	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR008946 InterPro:IPR000536	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	F	From MGI
	GO:0045618	positive regulation of keratinocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:2180411 PMID:11891224^[2]	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0046965	retinoid X receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	F	From MGI
	GO:0050892	intestinal absorption	MGI:MGI:2153271 PMID:11687634^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183409	P	From MGI
	GO:0051929	positive regulation of calcium ion transport via voltage-gated calcium channel activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	P	From MGI
	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	MGI:MGI:3051725 PMID:15178742^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183404	P	From MGI
	GO:0060558	regulation of calcidiol 1-monooxygenase activity	MGI:MGI:1097206 PMID:9295274^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060745	mammary gland branching involved in pregnancy	MGI:MGI:3051725 PMID:15178742^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2183404	P	From MGI
	GO:0070561	vitamin D receptor signaling pathway	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P13053	P	From MGI
	GO:0070561	vitamin D receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P11473	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Yoshizawa T et al. (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Gonzalez MM & Carlberg C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J Biol Chem 277: 18501-9 PubMed GONUTS page
↑ Kabe Y et al. (2005) NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol 25: 512-22 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem 279: 48329-41 PubMed GONUTS page
↑ Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J 15: 6701-15 PubMed GONUTS page
↑ ^6.0 ^6.1 Van Cromphaut SJ et al. (2001) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A 98: 13324-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Zinser GM & Welsh J (2004) Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol 18: 2208-23 PubMed GONUTS page
↑ Takeyama K et al. (1997) 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science 277: 1827-30 PubMed GONUTS page

[PMID:9241280-0] 1.0 ^1.1 ^1.2 ^1.3 Yoshizawa T et al. (1997) Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-6 PubMed GONUTS page

[PMID:11891224-1] 2.0 ^2.1 Gonzalez MM & Carlberg C (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J Biol Chem 277: 18501-9 PubMed GONUTS page

[PMID:15601870-2] Kabe Y et al. (2005) NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol 25: 512-22 PubMed GONUTS page

[PMID:15322135-3] 4.0 ^4.1 ^4.2 Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem 279: 48329-41 PubMed GONUTS page

[PMID:8978696-4] Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J 15: 6701-15 PubMed GONUTS page

[PMID:11687634-5] 6.0 ^6.1 Van Cromphaut SJ et al. (2001) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A 98: 13324-9 PubMed GONUTS page

[PMID:15178742-6] 7.0 ^7.1 ^7.2 Zinser GM & Welsh J (2004) Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice. Mol Endocrinol 18: 2208-23 PubMed GONUTS page

[PMID:9295274-7] Takeyama K et al. (1997) 25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis. Science 277: 1827-30 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Vdr ( synonyms: Nr1i1 )
Protein Name(s)	vitamin D receptor,
External Links
MGI	MGI:103076

MGI:Vdr

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