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MGI:Vangl2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Vangl2 ( synonyms: loop-tail, Lpp1, Ltap, ska, ska17, strabismus ) | |
| Protein Name(s) | vang-like 2 (van gogh, Drosophila), | |
| External Links | ||
| MGI | MGI:2135272 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0001736 |
establishment of planar polarity |
MGI:MGI:2657050 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001736 |
establishment of planar polarity |
MGI:MGI:3618551 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001736 |
establishment of planar polarity |
MGI:MGI:4819429 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2655333 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:2153976 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:2449213 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:2676511 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:105056 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:3046397 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1918711 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:3703464 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107926 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:3714704 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0001942 |
hair follicle development |
MGI:MGI:3835694 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:2157686 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003148 |
outflow tract septum morphogenesis |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0003149 |
membranous septum morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0003150 |
muscular septum morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0003347 |
epicardial cell to mesenchymal cell transition |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0003402 |
planar cell polarity pathway involved in axis elongation |
MGI:MGI:3793375 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108078 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3525406 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3624469 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3835694 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4359544 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4829604 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4887519 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4939857 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:3693056 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3714704 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4829604 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:4887519 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007266 |
Rho protein signal transduction |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3835694 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:3525406 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:4887519 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:3624469 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016328 |
lateral plasma membrane |
MGI:MGI:3714704 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0022007 |
convergent extension involved in neural plate elongation |
MGI:MGI:3624185 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106613 |
P |
From MGI |
||
| GO:0022007 |
convergent extension involved in neural plate elongation |
MGI:MGI:3624185 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0022007 |
convergent extension involved in neural plate elongation |
MGI:MGI:3703464 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0032956 |
regulation of actin cytoskeleton organization |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:3849215 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035058 |
nonmotile primary cilium assembly |
MGI:MGI:3607949 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1277215 |
P |
From MGI |
||
| GO:0035567 |
non-canonical Wnt receptor signaling pathway |
MGI:MGI:3849215 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035787 |
cell migration involved in kidney development |
MGI:MGI:4887519 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042060 |
wound healing |
MGI:MGI:4819429 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2655333 |
P |
From MGI |
||
| GO:0043507 |
positive regulation of JUN kinase activity |
MGI:MGI:4829604 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1923484 |
P |
From MGI |
||
| GO:0045176 |
apical protein localization |
MGI:MGI:3616416 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0045176 |
apical protein localization |
MGI:MGI:3624469 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0045197 |
establishment or maintenance of epithelial cell apical/basal polarity |
MGI:MGI:3702232 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3038823 |
P |
From MGI |
||
| GO:0048103 |
somatic stem cell division |
MGI:MGI:3849215 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048105 |
establishment of body hair planar orientation |
MGI:MGI:3835694 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0048546 |
digestive tract morphogenesis |
MGI:MGI:3839161 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108078 |
P |
From MGI |
||
| GO:0060028 |
convergent extension involved in axis elongation |
MGI:MGI:3703464 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060029 |
convergent extension involved in organogenesis |
MGI:MGI:3714704 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0060071 |
Wnt receptor signaling pathway, planar cell polarity pathway |
MGI:MGI:3589836 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060071 |
Wnt receptor signaling pathway, planar cell polarity pathway |
MGI:MGI:3714704 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0060071 |
Wnt receptor signaling pathway, planar cell polarity pathway |
MGI:MGI:4359544 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1891740 |
P |
From MGI |
||
| GO:0060119 |
inner ear receptor cell development |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0060122 |
inner ear receptor stereocilium organization |
MGI:MGI:3814781 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060187 |
cell pole |
MGI:MGI:3849215 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0060488 |
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060489 |
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060490 |
lateral sprouting involved in lung morphogenesis |
MGI:MGI:4452277 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0060947 |
cardiac vascular smooth muscle cell differentiation |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:3589836 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:3714704 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98958 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:3814781 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:3821448 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108100 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:4819429 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2655333 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1888513 |
P |
From MGI |
||
| GO:0090162 |
establishment of epithelial cell polarity |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0090175 |
regulation of establishment of planar polarity |
MGI:MGI:3839161 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108078 |
P |
From MGI |
||
| GO:0090177 |
establishment of planar polarity involved in neural tube closure |
MGI:MGI:3814781 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:3624185 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:106613 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:3624185 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857642 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:3793375 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108078 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:3821448 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:108100 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:4819429 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2655333 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:4830023 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1918711 |
P |
From MGI |
||
| GO:0090179 |
planar cell polarity pathway involved in neural tube closure |
MGI:MGI:4837757 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1196625 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
- ↑ Montcouquiol M et al. (2003) Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423: 173-7 PubMed GONUTS page
- ↑ Phillips HM et al. (2005) Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract. Circ Res 96: 292-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Caddy J et al. (2010) Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell 19: 138-47 PubMed GONUTS page
- ↑ Murdoch JN et al. (2001) Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification. Hum Mol Genet 10: 2593-601 PubMed GONUTS page
- ↑ Murdoch JN et al. (2003) Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum Mol Genet 12: 87-98 PubMed GONUTS page
- ↑ Carroll EA et al. (2003) Cordon-bleu is a conserved gene involved in neural tube formation. Dev Biol 262: 16-31 PubMed GONUTS page
- ↑ Lu X et al. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430: 93-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Ybot-Gonzalez P et al. (2007) Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134: 789-99 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 Qian D et al. (2007) Wnt5a functions in planar cell polarity regulation in mice. Dev Biol 306: 121-33 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Devenport D & Fuchs E (2008) Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol 10: 1257-68 PubMed GONUTS page
- ↑ Henderson DJ et al. (2001) Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant. Circ Res 89: 6-12 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Yu H et al. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development 137: 3707-17 PubMed GONUTS page
- ↑ 14.0 14.1 Satoh W et al. (2008) Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis 46: 92-103 PubMed GONUTS page
- ↑ 15.0 15.1 Torban E et al. (2004) Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. J Biol Chem 279: 52703-13 PubMed GONUTS page
- ↑ 16.0 16.1 16.2 Montcouquiol M et al. (2006) Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci 26: 5265-75 PubMed GONUTS page
- ↑ 17.0 17.1 Suriben R et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet 41: 977-85 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Yao R et al. (2004) MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene 23: 6023-30 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 19.3 Babayeva S et al. (2011) Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes. Am J Physiol Renal Physiol 300: F549-60 PubMed GONUTS page
- ↑ Li S et al. (2011) Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity. Proc Natl Acad Sci U S A 108: 2264-9 PubMed GONUTS page
- ↑ 21.0 21.1 21.2 21.3 21.4 21.5 Yates LL et al. (2010) The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis. Hum Mol Genet 19: 2251-67 PubMed GONUTS page
- ↑ Torban E et al. (2007) Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr Patterns 7: 346-54 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Wang J et al. (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development 133: 1767-78 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 Le Grand F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell 4: 535-47 PubMed GONUTS page
- ↑ Ross AJ et al. (2005) Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet 37: 1135-40 PubMed GONUTS page
- ↑ Wang Y et al. (2006) The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci 26: 2147-56 PubMed GONUTS page
- ↑ Deans MR et al. (2007) Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. J Neurosci 27: 3139-47 PubMed GONUTS page
- ↑ 28.0 28.1 Matsuyama M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet 5: e1000427 PubMed GONUTS page
- ↑ 29.0 29.1 Wang J et al. (2005) Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet 37: 980-5 PubMed GONUTS page
- ↑ 30.0 30.1 30.2 Yamamoto S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell 15: 23-36 PubMed GONUTS page
- ↑ 31.0 31.1 Etheridge SL et al. (2008) Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet 4: e1000259 PubMed GONUTS page
- ↑ Paudyal A et al. (2010) The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol 10: 87 PubMed GONUTS page
