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MGI:Unc5c

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Unc5c ( synonyms: Unc5h3 )
Protein Name(s) unc-5 homolog C (C. elegans),
External Links
MGI MGI:1095412

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004872

receptor activity

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0675

F

From MGI

GO:0005042

netrin receptor activity

MGI:MGI:1888865
PMID:10964959[1]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:1888865
PMID:10964959[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9QY50

F

From MGI

GO:0005886

plasma membrane

MGI:MGI:1888865
PMID:10964959[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006915

apoptotic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0053

P

From MGI

GO:0007165

signal transduction

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR000488

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0007420

brain development

MGI:MGI:1201748
PMID:9550145[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857013

P

From MGI

GO:0007420

brain development

MGI:MGI:1858682
PMID:10818148[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857852

P

From MGI

GO:0007420

brain development

MGI:MGI:50351
PMID:1401878[4]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857013

P

From MGI

GO:0007420

brain development

MGI:MGI:87586
PMID:9126743[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857852
MGI:MGI:1857013

P

From MGI

GO:0016020

membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From MGI

GO:0016021

integral to membrane

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From MGI

GO:0030334

regulation of cell migration

MGI:MGI:1195628
PMID:9389662[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857013

P

From MGI

GO:0030334

regulation of cell migration

MGI:MGI:1858682
PMID:10818148[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857852

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3775319
PMID:18077458[7]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857852

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Nakashiba T et al. (2000) Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. J Neurosci 20: 6540-50 PubMed GONUTS page
  2. Eisenman LM & Brothers R (1998) Rostral cerebellar malformation (rcm/rcm): a murine mutant to study regionalization of the cerebellum. J Comp Neurol 394: 106-17 PubMed GONUTS page
  3. 3.0 3.1 Goldowitz D et al. (2000) Granule cells and cerebellar boundaries: analysis of Unc5h3 mutant chimeras. J Neurosci 20: 4129-37 PubMed GONUTS page
  4. Lane PW et al. (1992) Rostral cerebellar malformation, (rcm): a new recessive mutation on chromosome 3 of the mouse. J Hered 83: 315-8 PubMed GONUTS page
  5. Ackerman SL et al. (1997) The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386: 838-42 PubMed GONUTS page
  6. Przyborski SA et al. (1998) Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development 125: 41-50 PubMed GONUTS page
  7. Hu Z et al. (2008) The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c. J Biol Chem 283: 3866-76 PubMed GONUTS page
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