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MGI:Ube4b

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Ube4b ( synonyms: D4Bwg0973e, UFD2, UFD2a, Ufd2p )
Protein Name(s) ubiquitination factor E4B, UFD2 homolog (S. cerevisiae),
External Links
MGI MGI:1927086

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000151

ubiquitin ligase complex

MGI:MGI:2449210
PMID:12504083[1]

TAS: Traceable Author Statement

C

From MGI

GO:0000209

protein polyubiquitination

MGI:MGI:2149486
PMID:11435423[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000209

protein polyubiquitination

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0003222

ventricular trabecula myocardium morphogenesis

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0004842

ubiquitin-protein ligase activity

MGI:MGI:2149486
PMID:11435423[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004842

ubiquitin-protein ligase activity

MGI:MGI:2449210
PMID:12504083[1]

TAS: Traceable Author Statement

F

From MGI

GO:0004842

ubiquitin-protein ligase activity

MGI:MGI:4441570
PMID:20017557[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0004842

ubiquitin-protein ligase activity

MGI:MGI:4833839
PMID:15466860[5]

IDA: Inferred from Direct Assay

F

From MGI

GO:0005515

protein binding

MGI:MGI:2449210
PMID:12504083[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q01853

F

From MGI

GO:0005515

protein binding

MGI:MGI:4833839
PMID:15466860[5]

IPI: Inferred from Physical Interaction

UniProtKB:Q99689

F

From MGI

GO:0005634

nucleus

MGI:MGI:2149486
PMID:11435423[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2449210
PMID:12504083[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0006457

protein folding

MGI:MGI:2449210
PMID:12504083[1]

NAS: Non-traceable Author Statement

P

From MGI

GO:0006511

ubiquitin-dependent protein catabolic process

MGI:MGI:2449210
PMID:12504083[1]

TAS: Traceable Author Statement

P

From MGI

GO:0006511

ubiquitin-dependent protein catabolic process

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O95155

P

From MGI

GO:0009411

response to UV

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:O95155

P

From MGI

GO:0016567

protein ubiquitination

MGI:MGI:4833839
PMID:15466860[5]

IDA: Inferred from Direct Assay

P

From MGI

GO:0019899

enzyme binding

MGI:MGI:2449210
PMID:12504083[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q01853

F

From MGI

GO:0031175

neuron projection development

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

RefSeq:XP_233679.3

P

From MGI

GO:0031175

neuron projection development

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0034450

ubiquitin-ubiquitin ligase activity

MGI:MGI:2149486
PMID:11435423[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0034976

response to endoplasmic reticulum stress

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0042787

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

MGI:MGI:2449210
PMID:12504083[1]

TAS: Traceable Author Statement

P

From MGI

GO:0044257

cellular protein catabolic process

MGI:MGI:3610695
PMID:16314518[3]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3611069

P

From MGI

GO:0051082

unfolded protein binding

MGI:MGI:2449210
PMID:12504083[1]

NAS: Non-traceable Author Statement

F

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Kaneko C et al. (2003) Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a. Biochem Biophys Res Commun 300: 297-304 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Hatakeyama S et al. (2001) U box proteins as a new family of ubiquitin-protein ligases. J Biol Chem 276: 33111-20 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Kaneko-Oshikawa C et al. (2005) Mammalian E4 is required for cardiac development and maintenance of the nervous system. Mol Cell Biol 25: 10953-64 PubMed GONUTS page
  4. Nordquist KA et al. (2010) Structural and functional characterization of the monomeric U-box domain from E4B. Biochemistry 49: 347-55 PubMed GONUTS page
  5. 5.0 5.1 5.2 Okumura F et al. (2004) Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J Biol Chem 279: 53533-43 PubMed GONUTS page
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