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MGI:Ube2b
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ube2b ( synonyms: E2-14k, HR6B, Rad6b ) | |
| Protein Name(s) | ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae), | |
| External Links | ||
| MGI | MGI:102944 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0000209 |
protein polyubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000785 |
chromatin |
MGI:MGI:3528534 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000790 |
nuclear chromatin |
MGI:MGI:3055251 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3050931 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:102959 |
P |
From MGI |
||
| GO:0001741 |
XY body |
MGI:MGI:3055251 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2448116 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2679894 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3718176 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3718176 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005657 |
replication fork |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006281 |
DNA repair |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006301 |
postreplication repair |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006344 |
maintenance of chromatin silencing |
MGI:MGI:3720437 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0006511 |
ubiquitin-dependent protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006513 |
protein monoubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006974 |
response to DNA damage stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007283 |
spermatogenesis |
MGI:MGI:1328888 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0007288 |
sperm axoneme assembly |
MGI:MGI:2668287 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0009411 |
response to UV |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0010845 |
positive regulation of reciprocal meiotic recombination |
MGI:MGI:2450033 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016567 |
protein ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0016881 |
acid-amino acid ligase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0031056 |
regulation of histone modification |
MGI:MGI:3720437 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0033128 |
negative regulation of histone phosphorylation |
MGI:MGI:3720437 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0033522 |
histone H2A ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042493 |
response to drug |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:2450033 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0043161 |
proteasomal ubiquitin-dependent protein catabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043951 |
negative regulation of cAMP-mediated signaling |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050821 |
protein stabilization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051026 |
chiasma assembly |
MGI:MGI:2450033 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0051865 |
protein autoubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3852303 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070076 |
histone lysine demethylation |
MGI:MGI:3720437 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0070193 |
synaptonemal complex organization |
MGI:MGI:2450033 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0070193 |
synaptonemal complex organization |
MGI:MGI:3720437 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183933 |
P |
From MGI |
||
| GO:0070534 |
protein K63-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070936 |
protein K48-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070979 |
protein K11-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Baarends WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 25: 1041-53 PubMed GONUTS page
- ↑ 2.0 2.1 van der Laan R et al. (2004) Ubiquitin ligase Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase. J Cell Sci 117: 5023-33 PubMed GONUTS page
- ↑ Roest HP et al. (2004) The ubiquitin-conjugating DNA repair enzyme HR6A is a maternal factor essential for early embryonic development in mice. Mol Cell Biol 24: 5485-95 PubMed GONUTS page
- ↑ Tateishi S et al. (2003) Enhanced genomic instability and defective postreplication repair in RAD18 knockout mouse embryonic stem cells. Mol Cell Biol 23: 474-81 PubMed GONUTS page
- ↑ Kwon YT et al. (2003) Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. Mol Cell Biol 23: 8255-71 PubMed GONUTS page
- ↑ 6.0 6.1 Tasaki T et al. (2007) Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems. J Biol Chem 282: 18510-20 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Baarends WM et al. (2007) Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome. J Cell Sci 120: 1841-51 PubMed GONUTS page
- ↑ Grootegoed JA et al. (1998) Knockout mouse model and gametogenic failure. Mol Cell Endocrinol 145: 161-6 PubMed GONUTS page
- ↑ Escalier D (2003) New insights into the assembly of the periaxonemal structures in mammalian spermatozoa. Biol Reprod 69: 373-8 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Baarends WM et al. (2003) Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase. Mol Cell Biol 23: 1151-62 PubMed GONUTS page
- ↑ Shekhar MP et al. (2008) Rad6B is a positive regulator of beta-catenin stabilization. Cancer Res 68: 1741-50 PubMed GONUTS page
