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MGI:Tyro3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tyro3 ( synonyms: Brt, Dtk, Etk-2, Rse, Sky, Tif ) | |
| Protein Name(s) | TYRO3 protein tyrosine kinase 3, | |
| External Links | ||
| MGI | MGI:104294 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0547 |
F |
From MGI |
||
| GO:0001779 |
natural killer cell differentiation |
MGI:MGI:3662985 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0004672 |
protein kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004713 |
protein tyrosine kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0067 |
F |
From MGI |
||
| GO:0005524 |
ATP binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:5315335 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005623 |
cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387762 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005635 |
nuclear envelope |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006468 |
protein phosphorylation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007155 |
cell adhesion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0130 |
P |
From MGI |
||
| GO:0007155 |
cell adhesion |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152096 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007283 |
spermatogenesis |
MGI:MGI:1335700 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016301 |
kinase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
F |
From MGI |
||
| GO:0016310 |
phosphorylation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0418 |
P |
From MGI |
||
| GO:0016740 |
transferase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0808 |
F |
From MGI |
||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0021885 |
forebrain cell migration |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0030168 |
platelet activation |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387762 |
P |
From MGI |
||
| GO:0032940 |
secretion by cell |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387762 |
P |
From MGI |
||
| GO:0034122 |
negative regulation of toll-like receptor signaling pathway |
MGI:MGI:3773763 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0034446 |
substrate adhesion-dependent cell spreading |
MGI:MGI:3528131 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2387762 |
P |
From MGI |
||
| GO:0042698 |
ovulation cycle |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3778590 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0043277 |
apoptotic cell clearance |
MGI:MGI:3836130 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3528131 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95660 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:5315335 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043524 |
negative regulation of neuron apoptotic process |
MGI:MGI:3817816 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0043548 |
phosphatidylinositol 3-kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043548 |
phosphatidylinositol 3-kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045824 |
negative regulation of innate immune response |
MGI:MGI:3773763 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0046777 |
protein autophosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:3817816 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3773763 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0051250 |
negative regulation of lymphocyte activation |
MGI:MGI:2137182 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0060068 |
vagina development |
MGI:MGI:3820485 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347244 |
P |
From MGI |
||
| GO:0070050 |
neuron homeostasis |
MGI:MGI:5315335 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070527 |
platelet aggregation |
MGI:MGI:5306558 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Caraux A et al. (2006) Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat Immunol 7: 747-54 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Angelillo-Scherrer A et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115: 237-46 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Zhong Z et al. (2010) Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci 30: 15521-34 PubMed GONUTS page
- ↑ Lu Q et al. (1999) Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-8 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Pierce A et al. (2008) Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration. Mol Endocrinol 22: 2481-95 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Rothlin CV et al. (2007) TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-36 PubMed GONUTS page
- ↑ Xiong W et al. (2008) Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells. Reproduction 135: 77-87 PubMed GONUTS page
- ↑ Seitz HM et al. (2007) Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol 178: 5635-42 PubMed GONUTS page
- ↑ Lu Q & Lemke G (2001) Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293: 306-11 PubMed GONUTS page
- ↑ Wu H et al. (2008) High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamily. Mol Reprod Dev 75: 1775-82 PubMed GONUTS page
- ↑ Cosemans JM et al. (2010) Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost 8: 1797-808 PubMed GONUTS page
