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MGI:Twist2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Twist2 ( synonyms: bHLHa39, Dermo1 ) | |
| Protein Name(s) | twist homolog 2 (Drosophila), | |
| External Links | ||
| MGI | MGI:104685 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2683822 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:107606 |
P |
From MGI |
||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3721468 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3831587 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99852 |
P |
From MGI |
||
| GO:0001076 |
RNA polymerase II transcription factor binding transcription factor activity |
MGI:MGI:2683822 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001649 |
osteoblast differentiation |
MGI:MGI:3042355 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003682 |
chromatin binding |
MGI:MGI:3721468 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:77180 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2683822 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3831587 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4839410 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:77180 |
IPI: Inferred from Physical Interaction |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:77180 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3831587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0010838 |
positive regulation of keratinocyte proliferation |
MGI:MGI:4949824 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:3042355 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030154 |
cell differentiation |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0221 |
P |
From MGI |
||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
MGI:MGI:3721468 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:98872 |
P |
From MGI |
||
| GO:0032720 |
negative regulation of tumor necrosis factor production |
MGI:MGI:3721468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043392 |
negative regulation of DNA binding |
MGI:MGI:2683822 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0044092 |
negative regulation of molecular function |
MGI:MGI:3042355 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045638 |
negative regulation of myeloid cell differentiation |
MGI:MGI:3831587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:3042355 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0045668 |
negative regulation of osteoblast differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:77180 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048701 |
embryonic cranial skeleton morphogenesis |
MGI:MGI:3042355 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99829 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:4939992 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:4949824 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
||
| GO:0061303 |
cornea development in camera-type eye |
MGI:MGI:4949824 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3044412 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Lee YS et al. (2003) Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c. Nucleic Acids Res 31: 7165-74 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Sharif MN et al. (2006) Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med 203: 1891-901 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Sharabi AB et al. (2008) Twist-2 controls myeloid lineage development and function. PLoS Biol 6: e316 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Bialek P et al. (2004) A twist code determines the onset of osteoblast differentiation. Dev Cell 6: 423-35 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Li L et al. (1995) Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol 172: 280-92 PubMed GONUTS page
- ↑ Fulzele K et al. (2010) Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142: 309-19 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Weaving L et al. (2010) Twist2: role in corneal stromal keratocyte proliferation and corneal thickness. Invest Ophthalmol Vis Sci 51: 5561-70 PubMed GONUTS page
- ↑ Tukel T et al. (2010) Homozygous nonsense mutations in TWIST2 cause Setleis syndrome. Am J Hum Genet 87: 289-96 PubMed GONUTS page
