GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Tsc2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tsc2 ( synonyms: tuberin ) | |
| Protein Name(s) | tuberous sclerosis 2, | |
| External Links | ||
| MGI | MGI:102548 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001666 |
response to hypoxia |
MGI:MGI:3773582 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001843 |
neural tube closure |
MGI:MGI:1333508 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926345 |
P |
From MGI |
||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
F |
From MGI |
|||
| GO:0005096 |
GTPase activator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2155582 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:1858852 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3050929 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1270849 |
C |
From MGI |
||
| GO:0005622 |
intracellular |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
EMBL:D50413 |
C |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:2155582 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005792 |
microsome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005901 |
caveola |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006469 |
negative regulation of protein kinase activity |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006606 |
protein import into nucleus |
MGI:MGI:1858852 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006953 |
acute-phase response |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:1333508 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926345 |
P |
From MGI |
||
| GO:0008104 |
protein localization |
MGI:MGI:2155582 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:1333508 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1926345 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:1345025 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857938 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:1858852 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3586938 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109583 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3586939 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109583 |
P |
From MGI |
||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0014065 |
phosphatidylinositol 3-kinase cascade |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0014067 |
negative regulation of phosphatidylinositol 3-kinase cascade |
MGI:MGI:3586939 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857938 |
P |
From MGI |
||
| GO:0019902 |
phosphatase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030030 |
cell projection organization |
MGI:MGI:3610880 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030100 |
regulation of endocytosis |
MGI:MGI:1858852 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030178 |
negative regulation of Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
P |
From MGI |
|||
| GO:0030425 |
dendrite |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0032007 |
negative regulation of TOR signaling cascade |
MGI:MGI:3773582 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032007 |
negative regulation of TOR signaling cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033596 |
TSC1-TSC2 complex |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
C |
From MGI |
|||
| GO:0033596 |
TSC1-TSC2 complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043407 |
negative regulation of MAP kinase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3050929 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1270849 |
P |
From MGI |
||
| GO:0043491 |
protein kinase B signaling cascade |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
P |
From MGI |
|||
| GO:0043547 |
positive regulation of GTPase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044430 |
cytoskeletal part |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045184 |
establishment of protein localization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045792 |
negative regulation of cell size |
MGI:MGI:3610880 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045792 |
negative regulation of cell size |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
P |
From MGI |
|||
| GO:0046626 |
regulation of insulin receptor signaling pathway |
MGI:MGI:2429349 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857938 |
P |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048009 |
insulin-like growth factor receptor signaling pathway |
MGI:MGI:3050929 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1270849 |
P |
From MGI |
||
| GO:0048009 |
insulin-like growth factor receptor signaling pathway |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0050918 |
positive chemotaxis |
MGI:MGI:3050929 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051260 |
protein homooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051291 |
protein heterooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051726 |
regulation of cell cycle |
MGI:MGI:4459044 |
PANTHER:PTHR10063 |
P |
From MGI |
|||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
MGI:MGI:3586939 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109583 |
P |
From MGI |
||
| GO:0051898 |
negative regulation of protein kinase B signaling cascade |
MGI:MGI:3586939 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857938 |
P |
From MGI |
||
| GO:0071889 |
14-3-3 protein binding |
MGI:MGI:3773582 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 DeYoung MP et al. (2008) Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 22: 239-51 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Kobayashi T et al. (1999) Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 59: 1206-11 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Nellist M et al. (2001) TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex. Hum Mol Genet 10: 2889-98 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Pasumarthi KB et al. (2000) Enhanced cardiomyocyte DNA synthesis during myocardial hypertrophy in mice expressing a modified TSC2 transgene. Circ Res 86: 1069-77 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Harrington LS et al. (2004) The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 166: 213-23 PubMed GONUTS page
- ↑ Onda H et al. (1999) Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 104: 687-95 PubMed GONUTS page
- ↑ Ma L et al. (2005) Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev 19: 1779-86 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Manning BD et al. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev 19: 1773-8 PubMed GONUTS page
- ↑ 9.0 9.1 Tavazoie SF et al. (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8: 1727-34 PubMed GONUTS page
- ↑ Jaeschke A et al. (2002) Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 159: 217-24 PubMed GONUTS page
