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MGI:Trp53

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Trp53 ( synonyms: p44, p53 )
Protein Name(s) transformation related protein 53,
External Links
MGI MGI:98834

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000060

protein import into nucleus, translocation

MGI:MGI:2176657
PMID:11799106[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3528807
PMID:15657445[2]

IGI: Inferred from Genetic Interaction

MGI:MGI:106203

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3797158
PMID:18212064[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:98725

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:3850294
PMID:19411634[4]

IGI: Inferred from Genetic Interaction

MGI:MGI:95661

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:5009365
PMID:19749791[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:66992
PMID:8183579[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000733

DNA strand renaturation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0000739

DNA strand annealing activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0000785

chromatin

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0000785

chromatin

MGI:MGI:4459044

PANTHER:PTHR11447

C

From MGI

GO:0000790

nuclear chromatin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0001077

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

MGI:MGI:3690827
PMID:16286009[7]

IGI: Inferred from Genetic Interaction

MGI:MGI:1096393

F

From MGI

GO:0001085

RNA polymerase II transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:1096207
PMID:9288110[8]

IGI: Inferred from Genetic Interaction

MGI:MGI:101816

P

From MGI

GO:0001701

in utero embryonic development

MGI:MGI:3709911
PMID:17325035[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:1343101

P

From MGI

GO:0001756

somitogenesis

MGI:MGI:3709913
PMID:17320900[10]

IGI: Inferred from Genetic Interaction

MGI:MGI:1343101

P

From MGI

GO:0001836

release of cytochrome c from mitochondria

MGI:MGI:3042308
PMID:14963330[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

P

From MGI

GO:0001836

release of cytochrome c from mitochondria

MGI:MGI:3574697
PMID:15483136[12]

IDA: Inferred from Direct Assay

P

From MGI

GO:0002020

protease binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0002039

p53 binding

MGI:MGI:4459044

PANTHER:PTHR11447

F

From MGI

GO:0002309

T cell proliferation involved in immune response

MGI:MGI:3610868
PMID:16357222[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:98159

P

From MGI

GO:0002326

B cell lineage commitment

MGI:MGI:78866
PMID:8788039[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0002360

T cell lineage commitment

MGI:MGI:78866
PMID:8788039[14]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0002687

positive regulation of leukocyte migration

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0003677

DNA binding

MGI:MGI:1336373
PMID:10205143[15]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:2183272
PMID:12135983[16]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:3589512
PMID:16107883[17]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:3612630
PMID:16363065[18]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003677

DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3528807
PMID:15657445[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003682

chromatin binding

MGI:MGI:3797158
PMID:18212064[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003684

damaged DNA binding

MGI:MGI:4459044

PANTHER:PTHR11447

F

From MGI

GO:0003690

double-stranded DNA binding

MGI:MGI:4459044

PANTHER:PTHR11447

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:2183272
PMID:12135983[16]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:3612718
PMID:16044147[19]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:3619675
PMID:16098148[20]

IDA: Inferred from Direct Assay

F

From MGI

GO:0003700

sequence-specific DNA binding transcription factor activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0005507

copper ion binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0005515

protein binding

MGI:MGI:1336373
PMID:10205143[15]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:1336979
PMID:10329696[21]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z2R2

F

From MGI

GO:0005515

protein binding

MGI:MGI:1860990
PMID:10894779[22]

IPI: Inferred from Physical Interaction

UniProtKB:Q9JJP1

F

From MGI

GO:0005515

protein binding

MGI:MGI:2152474
PMID:11672522[23]

IPI: Inferred from Physical Interaction

UniProtKB:Q923E4

F

From MGI

GO:0005515

protein binding

MGI:MGI:2176657
PMID:11799106[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z1E3

F

From MGI

GO:0005515

protein binding

MGI:MGI:2178004
PMID:11900485[24]

IPI: Inferred from Physical Interaction

UniProtKB:P38647

F

From MGI

GO:0005515

protein binding

MGI:MGI:3042308
PMID:14963330[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q64373-1

F

From MGI

GO:0005515

protein binding

MGI:MGI:3053255
PMID:15364958[25]

IPI: Inferred from Physical Interaction

UniProtKB:P70399

F

From MGI

GO:0005515

protein binding

MGI:MGI:3521522
PMID:15526030[26]

IPI: Inferred from Physical Interaction

UniProtKB:O35625
UniProtKB:Q9QZR5

F

From MGI

GO:0005515

protein binding

MGI:MGI:3529885
PMID:15678128[27]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:3578084
PMID:15735665[28]

IPI: Inferred from Physical Interaction

UniProtKB:Q80Z37

F

From MGI

GO:0005515

protein binding

MGI:MGI:3583493
PMID:15989966[29]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:3603103
PMID:16151013[30]

IPI: Inferred from Physical Interaction

UniProtKB:Q64373

F

From MGI

GO:0005515

protein binding

MGI:MGI:3688025
PMID:11781573[31]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005515

protein binding

MGI:MGI:3720993
PMID:17591690[32]

IPI: Inferred from Physical Interaction

UniProtKB:P23804
UniProtKB:Q8BJ14
UniProtKB:P49615

F

From MGI

GO:0005515

protein binding

MGI:MGI:3760347
PMID:17936560[33]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:3794005
PMID:18303029[34]

IPI: Inferred from Physical Interaction

UniProtKB:Q61466

F

From MGI

GO:0005515

protein binding

MGI:MGI:3794959
PMID:18332125[35]

IPI: Inferred from Physical Interaction

UniProtKB:O08586

F

From MGI

GO:0005515

protein binding

MGI:MGI:3850294
PMID:19411634[4]

IPI: Inferred from Physical Interaction

UniProtKB:P17679

F

From MGI

GO:0005515

protein binding

MGI:MGI:3851860
PMID:19556538[36]

IPI: Inferred from Physical Interaction

UniProtKB:Q64127

F

From MGI

GO:0005515

protein binding

MGI:MGI:4830897
PMID:20832751[37]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0005515

protein binding

MGI:MGI:4943791
PMID:20697359[38]

IPI: Inferred from Physical Interaction

UniProtKB:P23804-1

F

From MGI

GO:0005515

protein binding

MGI:MGI:5009192
PMID:11274052[39]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005515

protein binding

MGI:MGI:5139951
PMID:21741598[40]

IPI: Inferred from Physical Interaction

UniProtKB:Q9QUR7

F

From MGI

GO:0005515

protein binding

MGI:MGI:5285177
PMID:16480949[41]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005515

protein binding

MGI:MGI:5294295
PMID:17535810[42]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005515

protein binding

MGI:MGI:5294529
PMID:20599664[43]

IPI: Inferred from Physical Interaction

UniProtKB:Q15327

F

From MGI

GO:0005515

protein binding

MGI:MGI:5315373
PMID:11181729[44]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005515

protein binding

MGI:MGI:5315696
PMID:18025262[45]

IPI: Inferred from Physical Interaction

UniProtKB:P03070

F

From MGI

GO:0005524

ATP binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0005622

intracellular

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

C

From MGI

GO:0005622

intracellular

MGI:MGI:3589512
PMID:16107883[17]

IGI: Inferred from Genetic Interaction

MGI:MGI:108027

C

From MGI

GO:0005622

intracellular

MGI:MGI:3603875
PMID:16199867[47]

IGI: Inferred from Genetic Interaction

MGI:MGI:106184

C

From MGI

GO:0005622

intracellular

MGI:MGI:3652689
PMID:16777961[48]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857263

C

From MGI

GO:0005622

intracellular

MGI:MGI:3690827
PMID:16286009[7]

IGI: Inferred from Genetic Interaction

MGI:MGI:1096393

C

From MGI

GO:0005622

intracellular

MGI:MGI:3714678
PMID:17476307[49]

IGI: Inferred from Genetic Interaction

MGI:MGI:109337

C

From MGI

GO:0005622

intracellular

MGI:MGI:4944151
PMID:20818388[50]

IMP: Inferred from Mutant Phenotype

C

From MGI

GO:0005625

soluble fraction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005626

insoluble fraction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005634

nucleus

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005634

nucleus

MGI:MGI:2176657
PMID:11799106[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2178004
PMID:11900485[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2449362
PMID:12524542[51]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3027643
PMID:14729462[52]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3720993
PMID:17591690[32]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3794959
PMID:18332125[35]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3798119
PMID:18545656[53]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005654

nucleoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005657

replication fork

MGI:MGI:3053255
PMID:15364958[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005667

transcription factor complex

MGI:MGI:4459044

PANTHER:PTHR11447

C

From MGI

GO:0005678

chromatin assembly complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005730

nucleolus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2176657
PMID:11799106[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2178004
PMID:11900485[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:2449362
PMID:12524542[51]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:3042308
PMID:14963330[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4459044

PANTHER:PTHR11447

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0005739

mitochondrion

MGI:MGI:5315364
PMID:12667443[54]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005783

endoplasmic reticulum

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0256

C

From MGI

GO:0005829

cytosol

MGI:MGI:2176657
PMID:11799106[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005829

cytosol

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

C

From MGI

GO:0005829

cytosol

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0006289

nucleotide-excision repair

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006302

double-strand break repair

MGI:MGI:3770581
PMID:17912366[55]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857989

P

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:2183272
PMID:12135983[16]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006461

protein complex assembly

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3042308
PMID:14963330[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3511396
PMID:15485914[56]

IGI: Inferred from Genetic Interaction

MGI:MGI:97740

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3603971
PMID:16183742[57]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:3709911
PMID:17325035[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:1343101

P

From MGI

GO:0006915

apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006917

induction of apoptosis

MGI:MGI:3589512
PMID:16107883[17]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006917

induction of apoptosis

MGI:MGI:3700903
PMID:17210642[58]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:3032464
PMID:14744935[59]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:3057054
PMID:15383658[60]

IDA: Inferred from Direct Assay

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:3691523
PMID:11092819[61]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:3720993
PMID:17591690[32]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

MGI:MGI:3589512
PMID:16107883[17]

IGI: Inferred from Genetic Interaction

MGI:MGI:108027

P

From MGI

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

MGI:MGI:4459044

PANTHER:PTHR11447

P

From MGI

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0006979

response to oxidative stress

MGI:MGI:3720993
PMID:17591690[32]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0006983

ER overload response

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007050

cell cycle arrest

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0007179

transforming growth factor beta receptor signaling pathway

MGI:MGI:3797158
PMID:18212064[3]

IGI: Inferred from Genetic Interaction

MGI:MGI:98725
MGI:MGI:108051
MGI:MGI:894293

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0007369

gastrulation

MGI:MGI:3696931
PMID:17000767[62]

IGI: Inferred from Genetic Interaction

MGI:MGI:98159

P

From MGI

GO:0007406

negative regulation of neuroblast proliferation

MGI:MGI:1203920
PMID:9608530[63]

IGI: Inferred from Genetic Interaction

MGI:MGI:97306

P

From MGI

GO:0007417

central nervous system development

MGI:MGI:3603875
PMID:16199867[47]

IGI: Inferred from Genetic Interaction

MGI:MGI:1335098

P

From MGI

GO:0007569

cell aging

MGI:MGI:3692019
PMID:17053789[64]

IGI: Inferred from Genetic Interaction

MGI:MGI:1920086

P

From MGI

GO:0007569

cell aging

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0008022

protein C-terminus binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

F

From MGI

GO:0008104

protein localization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0008134

transcription factor binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0008156

negative regulation of DNA replication

MGI:MGI:3032953
PMID:11884608[65]

IDA: Inferred from Direct Assay

P

From MGI

GO:0008156

negative regulation of DNA replication

MGI:MGI:3032953
PMID:11884608[65]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1350531
PMID:10591652[66]

IGI: Inferred from Genetic Interaction

MGI:MGI:97306

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1350533
PMID:10591653[67]

IGI: Inferred from Genetic Interaction

MGI:MGI:97306

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:1889141
PMID:10973261[68]

IGI: Inferred from Genetic Interaction

MGI:MGI:97306

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:2445783
PMID:11246230[69]

IGI: Inferred from Genetic Interaction

MGI:MGI:97306

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:3589512
PMID:16107883[17]

IGI: Inferred from Genetic Interaction

MGI:MGI:108027

P

From MGI

GO:0008285

negative regulation of cell proliferation

MGI:MGI:5009365
PMID:19749791[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0008340

determination of adult lifespan

MGI:MGI:4944151
PMID:20818388[50]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0009303

rRNA transcription

MGI:MGI:3822232
PMID:18809582[70]

IGI: Inferred from Genetic Interaction

MGI:MGI:104738

P

From MGI

GO:0009411

response to UV

MGI:MGI:1858868
PMID:10815637[71]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0009411

response to UV

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0009411

response to UV

MGI:MGI:3032464
PMID:14744935[59]

IDA: Inferred from Direct Assay

P

From MGI

GO:0009411

response to UV

MGI:MGI:3691523
PMID:11092819[61]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0009651

response to salt stress

MGI:MGI:3654719
PMID:16571598[72]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702
MGI:MGI:102845

P

From MGI

GO:0009792

embryo development ending in birth or egg hatching

MGI:MGI:3624572
PMID:16702401[73]

IGI: Inferred from Genetic Interaction

MGI:MGI:2138319

P

From MGI

GO:0010165

response to X-ray

MGI:MGI:3032953
PMID:11884608[65]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010332

response to gamma radiation

MGI:MGI:3032464
PMID:14744935[59]

IDA: Inferred from Direct Assay

P

From MGI

GO:0010332

response to gamma radiation

MGI:MGI:3722566
PMID:17068116[74]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0010332

response to gamma radiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0016363

nuclear matrix

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0016605

PML body

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0019899

enzyme binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0019901

protein kinase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0030308

negative regulation of cell growth

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0030330

DNA damage response, signal transduction by p53 class mediator

MGI:MGI:2156961
PMID:11790307[75]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030330

DNA damage response, signal transduction by p53 class mediator

MGI:MGI:3032953
PMID:11884608[65]

IDA: Inferred from Direct Assay

P

From MGI

GO:0030330

DNA damage response, signal transduction by p53 class mediator

MGI:MGI:3603875
PMID:16199867[47]

IGI: Inferred from Genetic Interaction

MGI:MGI:106184

P

From MGI

GO:0030330

DNA damage response, signal transduction by p53 class mediator

MGI:MGI:3714678
PMID:17476307[49]

IGI: Inferred from Genetic Interaction

MGI:MGI:109337

P

From MGI

GO:0030330

DNA damage response, signal transduction by p53 class mediator

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

MGI:MGI:3528807
PMID:15657445[2]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031065

positive regulation of histone deacetylation

MGI:MGI:3528807
PMID:15657445[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0031571

mitotic cell cycle G1/S transition DNA damage checkpoint

MGI:MGI:3589512
PMID:16107883[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0031571

mitotic cell cycle G1/S transition DNA damage checkpoint

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0031625

ubiquitin protein ligase binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

F

From MGI

GO:0031625

ubiquitin protein ligase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0032461

positive regulation of protein oligomerization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0033077

T cell differentiation in thymus

MGI:MGI:3610868
PMID:16357222[13]

IGI: Inferred from Genetic Interaction

MGI:MGI:98159

P

From MGI

GO:0034613

cellular protein localization

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0034644

cellular response to UV

MGI:MGI:3042308
PMID:14963330[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

P

From MGI

GO:0035033

histone deacetylase regulator activity

MGI:MGI:3528807
PMID:15657445[2]

IDA: Inferred from Direct Assay

F

From MGI

GO:0035035

histone acetyltransferase binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0035264

multicellular organism growth

MGI:MGI:3709911
PMID:17325035[9]

IGI: Inferred from Genetic Interaction

MGI:MGI:1343101

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:1354560
PMID:10716720[76]

IGI: Inferred from Genetic Interaction

MGI:MGI:88039

P

From MGI

GO:0042127

regulation of cell proliferation

MGI:MGI:2670239
PMID:12878730[77]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857263

P

From MGI

GO:0042149

cellular response to glucose starvation

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0042493

response to drug

MGI:MGI:87440
PMID:9098922[78]

IDA: Inferred from Direct Assay

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:2682549
PMID:14654789[79]

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:3652689
PMID:16777961[48]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857263

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:3690827
PMID:16286009[7]

IGI: Inferred from Genetic Interaction

MGI:MGI:1096393

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:3714678
PMID:17476307[49]

IGI: Inferred from Genetic Interaction

MGI:MGI:109337

P

From MGI

GO:0042771

DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:4944151
PMID:20818388[50]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0042802

identical protein binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0042981

regulation of apoptotic process

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3654719
PMID:16571598[72]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702
MGI:MGI:102845

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:3722566
PMID:17068116[74]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0043065

positive regulation of apoptotic process

MGI:MGI:85706
PMID:9024662[80]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:3770581
PMID:17912366[55]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857989

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:66992
PMID:8183579[6]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0043234

protein complex

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

C

From MGI

GO:0043523

regulation of neuron apoptotic process

MGI:MGI:3574697
PMID:15483136[12]

IGI: Inferred from Genetic Interaction

MGI:MGI:1336991

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:1203920
PMID:9608530[63]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857263

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:1860400
PMID:10911993[81]

IGI: Inferred from Genetic Interaction

MGI:MGI:1335098

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:1860990
PMID:10894779[22]

IDA: Inferred from Direct Assay

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:1929535
PMID:11150333[82]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:3574697
PMID:15483136[12]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:3652689
PMID:16777961[48]

IGI: Inferred from Genetic Interaction

MGI:MGI:1927345

P

From MGI

GO:0043525

positive regulation of neuron apoptotic process

MGI:MGI:3691523
PMID:11092819[61]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857590

P

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

F

From MGI

GO:0043565

sequence-specific DNA binding

MGI:MGI:4459044

PANTHER:PTHR11447

F

From MGI

GO:0044212

transcription regulatory region DNA binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0045787

positive regulation of cell cycle

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:5009365
PMID:19749791[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3578084
PMID:15735665[28]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3578084
PMID:15735665[28]

IGI: Inferred from Genetic Interaction

MGI:MGI:2146189

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:3612718
PMID:16044147[19]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045893

positive regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3589512
PMID:16107883[17]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3619675
PMID:16098148[20]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:3850294
PMID:19411634[4]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:4459044

PANTHER:PTHR11447

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:66992
PMID:8183579[6]

IDA: Inferred from Direct Assay

P

From MGI

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

MGI:MGI:76511
PMID:7677753[83]

IDA: Inferred from Direct Assay

P

From MGI

GO:0046872

metal ion binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From MGI

GO:0046902

regulation of mitochondrial membrane permeability

MGI:MGI:3042308
PMID:14963330[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:99702

P

From MGI

GO:0046982

protein heterodimerization activity

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0047485

protein N-terminus binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0048147

negative regulation of fibroblast proliferation

MGI:MGI:2675761
PMID:12952892[46]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1926340

P

From MGI

GO:0048147

negative regulation of fibroblast proliferation

MGI:MGI:3763815
PMID:17332504[84]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0048147

negative regulation of fibroblast proliferation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0048662

negative regulation of smooth muscle cell proliferation

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

MGI:MGI:5009365
PMID:19749791[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051087

chaperone binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0051262

protein tetramerization

MGI:MGI:2152098

IEA: Inferred from Electronic Annotation

InterPro:IPR010991

P

From MGI

GO:0051276

chromosome organization

MGI:MGI:3692019
PMID:17053789[64]

IGI: Inferred from Genetic Interaction

MGI:MGI:1920086
MGI:MGI:2141503

P

From MGI

GO:0051276

chromosome organization

MGI:MGI:3695814
PMID:17200209[85]

IGI: Inferred from Genetic Interaction

MGI:MGI:88039

P

From MGI

GO:0051402

neuron apoptotic process

MGI:MGI:3720993
PMID:17591690[32]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051453

regulation of intracellular pH

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:0051721

protein phosphatase 2A binding

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

F

From MGI

GO:0051726

regulation of cell cycle

MGI:MGI:3583041
PMID:15898111[86]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857263

P

From MGI

GO:0051726

regulation of cell cycle

MGI:MGI:3794959
PMID:18332125[35]

IGI: Inferred from Genetic Interaction

MGI:MGI:109583

P

From MGI

GO:0070215

MDM2 binding

MGI:MGI:4944151
PMID:20818388[50]

IPI: Inferred from Physical Interaction

UniProtKB:P23804

F

From MGI

GO:0070245

positive regulation of thymocyte apoptotic process

MGI:MGI:4944151
PMID:20818388[50]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0071158

positive regulation of cell cycle arrest

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0071479

cellular response to ionizing radiation

MGI:MGI:3690827
PMID:16286009[7]

IGI: Inferred from Genetic Interaction

MGI:MGI:2181667
MGI:MGI:1096393

P

From MGI

GO:0071479

cellular response to ionizing radiation

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0071850

mitotic cell cycle arrest

MGI:MGI:3718924
PMID:17515607[87]

IDA: Inferred from Direct Assay

P

From MGI

GO:0072332

signal transduction by p53 class mediator resulting in induction of apoptosis

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0090200

positive regulation of release of cytochrome c from mitochondria

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0090343

positive regulation of cell aging

MGI:MGI:5142390
PMID:10562313[88]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0090399

replicative senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:0090403

oxidative stress-induced premature senescence

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:2000279

negative regulation of DNA biosynthetic process

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

UniProtKB:P10361

P

From MGI

GO:2000379

positive regulation of reactive oxygen species metabolic process

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:P04637

P

From MGI

NOT

GO:0001701

in utero embryonic development

MGI:MGI:1101752
PMID:9425892[89]

IGI: Inferred from Genetic Interaction

MGI:MGI:101816

P

From MGI


edit table

Notes

References

See Help:References for how to manage references in GONUTS.
  1. ↑ 1.0 1.1 1.2 1.3 1.4 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Wilkinson DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25: 1200-12 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Wilkinson DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol 28: 1988-98 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Trainor CD et al. (2009) GATA-1 associates with and inhibits p53. Blood 114: 165-73 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 Montano X (2009) Repression of SHP-1 expression by p53 leads to trkA tyrosine phosphorylation and suppression of breast cancer cell proliferation. Oncogene 28: 3787-800 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Miyashita T et al. (1994) Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-805 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 Wu WS et al. (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123: 641-53 PubMed GONUTS page
  8. ↑ Cranston A et al. (1997) Female embryonic lethality in mice nullizygous for both Msh2 and p53. Nat Genet 17: 114-8 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Bu P et al. (2007) Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol 27: 3405-16 PubMed GONUTS page
  10. ↑ Nueda ML et al. (2007) The EGF-like protein dlk1 inhibits notch signaling and potentiates adipogenesis of mesenchymal cells. J Mol Biol 367: 1281-93 PubMed GONUTS page
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Chipuk JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-4 PubMed GONUTS page
  12. ↑ 12.0 12.1 12.2 Lee AF et al. (2004) Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci 24: 9174-84 PubMed GONUTS page
  13. ↑ 13.0 13.1 Sulic S et al. (2005) Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev 19: 3070-82 PubMed GONUTS page
  14. ↑ 14.0 14.1 Li T et al. (1996) Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7: 107-14 PubMed GONUTS page
  15. ↑ 15.0 15.1 Leri A et al. (1999) Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice. Circ Res 84: 752-62 PubMed GONUTS page
  16. ↑ 16.0 16.1 16.2 Bourdon JC et al. (2002) Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J Cell Biol 158: 235-46 PubMed GONUTS page
  17. ↑ 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Doumont G et al. (2005) G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J 24: 3093-103 PubMed GONUTS page
  18. ↑ Kulesz-Martin M et al. (2005) Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles. J Investig Dermatol Symp Proc 10: 142-52 PubMed GONUTS page
  19. ↑ 19.0 19.1 Tomasini R et al. (2005) TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity. Oncogene 24: 8093-104 PubMed GONUTS page
  20. ↑ 20.0 20.1 Watanabe-Fukunaga R et al. (2005) SEI family of nuclear factors regulates p53-dependent transcriptional activation. Genes Cells 10: 851-60 PubMed GONUTS page
  21. ↑ Wadhwa R et al. (1999) Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53. J Biol Chem 274: 14948-55 PubMed GONUTS page
  22. ↑ 22.0 22.1 Pozniak CD et al. (2000) An anti-apoptotic role for the p53 family member, p73, during developmental neuron death. Science 289: 304-6 PubMed GONUTS page
  23. ↑ Luo J et al. (2001) Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-48 PubMed GONUTS page
  24. ↑ 24.0 24.1 24.2 Wadhwa R et al. (2002) Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein. Exp Cell Res 274: 246-53 PubMed GONUTS page
  25. ↑ 25.0 25.1 Sengupta S et al. (2004) Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166: 801-13 PubMed GONUTS page
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  28. ↑ 28.0 28.1 28.2 Lin L et al. (2005) topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage. Oncogene 24: 3385-96 PubMed GONUTS page
  29. ↑ Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell 19: 77-87 PubMed GONUTS page
  30. ↑ Chipuk JE et al. (2005) PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 309: 1732-5 PubMed GONUTS page
  31. ↑ Eyckerman S et al. (2001) Design and application of a cytokine-receptor-based interaction trap. Nat Cell Biol 3: 1114-9 PubMed GONUTS page
  32. ↑ 32.0 32.1 32.2 32.3 32.4 Lee JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci 120: 2259-71 PubMed GONUTS page
  33. ↑ Itahana K et al. (2007) Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 12: 355-66 PubMed GONUTS page
  34. ↑ Oh J et al. (2008) BAF60a interacts with p53 to recruit the SWI/SNF complex. J Biol Chem 283: 11924-34 PubMed GONUTS page
  35. ↑ 35.0 35.1 35.2 Chang CJ et al. (2008) PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol 28: 3281-9 PubMed GONUTS page
  36. ↑ Allton K et al. (2009) Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A 106: 11612-6 PubMed GONUTS page
  37. ↑ Macias E et al. (2010) An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell 18: 231-43 PubMed GONUTS page
  38. ↑ Giglio S et al. (2010) Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity. Oncogene 29: 5935-45 PubMed GONUTS page
  39. ↑ Rousset R et al. (2001) Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev 15: 658-71 PubMed GONUTS page
  40. ↑ Girardini JE et al. (2011) A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell 20: 79-91 PubMed GONUTS page
  41. ↑ Chen TY et al. (2006) The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein. Biochem Biophys Res Commun 342: 266-72 PubMed GONUTS page
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  43. ↑ Kojic S et al. (2010) A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein. Arch Biochem Biophys 502: 60-7 PubMed GONUTS page
  44. ↑ Vranová E et al. (2001) The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C. J Exp Bot 52: 181-2 PubMed GONUTS page
  45. ↑ Green CD et al. (2007) Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha. Mol Cancer Res 5: 1191-200 PubMed GONUTS page
  46. ↑ 46.0 46.1 46.2 46.3 46.4 46.5 Shibue T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev 17: 2233-8 PubMed GONUTS page
  47. ↑ 47.0 47.1 47.2 Colombo E et al. (2005) Nucleophosmin is required for DNA integrity and p19Arf protein stability. Mol Cell Biol 25: 8874-86 PubMed GONUTS page
  48. ↑ 48.0 48.1 48.2 Orii KE et al. (2006) Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A 103: 10017-22 PubMed GONUTS page
  49. ↑ 49.0 49.1 49.2 Frappart PO et al. (2007) BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J 26: 2732-42 PubMed GONUTS page
  50. ↑ 50.0 50.1 50.2 50.3 50.4 Liu D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12: 993-8 PubMed GONUTS page
  51. ↑ 51.0 51.1 Takeuchi A et al. (2003) Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. Nat Genet 33: 172-6 PubMed GONUTS page
  52. ↑ Zhang S et al. (2004) Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus. Exp Cell Res 293: 248-58 PubMed GONUTS page
  53. ↑ Park JY et al. (2008) Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PLoS One 3: e2346 PubMed GONUTS page
  54. ↑ Mihara M et al. (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11: 577-90 PubMed GONUTS page
  55. ↑ 55.0 55.1 Paul C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS One 2: e989 PubMed GONUTS page
  56. ↑ Sugo N et al. (2004) p53 Deficiency rescues neuronal apoptosis but not differentiation in DNA polymerase beta-deficient mice. Mol Cell Biol 24: 9470-7 PubMed GONUTS page
  57. ↑ Berube C et al. (2005) Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A 102: 14314-20 PubMed GONUTS page
  58. ↑ Babbe H et al. (2007) The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 27: 1947-59 PubMed GONUTS page
  59. ↑ 59.0 59.1 59.2 Qu L et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18: 261-77 PubMed GONUTS page
  60. ↑ You H et al. (2004) p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A 101: 14057-62 PubMed GONUTS page
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  62. ↑ Panić L et al. (2006) Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Mol Cell Biol 26: 8880-91 PubMed GONUTS page
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  64. ↑ 64.0 64.1 He H et al. (2006) POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J 25: 5180-90 PubMed GONUTS page
  65. ↑ 65.0 65.1 65.2 65.3 Shimura T et al. (2002) p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Mol Cell Biol 22: 2220-8 PubMed GONUTS page
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  68. ↑ Reilly KM et al. (2000) Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nat Genet 26: 109-13 PubMed GONUTS page
  69. ↑ Bajenaru ML et al. (2001) Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33: 314-23 PubMed GONUTS page
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  72. ↑ 72.0 72.1 Fan H et al. (2006) Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am J Physiol Renal Physiol 291: F670-82 PubMed GONUTS page
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  81. ↑ Frank KM et al. (2000) DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5: 993-1002 PubMed GONUTS page
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  88. ↑ Hudson JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med 190: 1375-82 PubMed GONUTS page
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