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MGI:Traf2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Traf2 | |
| Protein Name(s) | TNF receptor-associated factor 2, | |
| External Links | ||
| MGI | MGI:101835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002726 |
positive regulation of T cell cytokine production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0004842 |
ubiquitin-protein ligase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005102 |
receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
F |
From MGI |
||
| GO:0005174 |
CD40 receptor binding |
MGI:MGI:4462284 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1101440 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3687722 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3688344 |
IPI: Inferred from Physical Interaction |
UniProtKB:O08863 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3831253 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5009780 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5291889 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005938 |
cell cortex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
C |
From MGI |
||
| GO:0006461 |
protein complex assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
P |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0006916 |
anti-apoptosis |
MGI:MGI:3687722 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2680840 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008152 |
metabolic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008289 |
lipid binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0446 |
F |
From MGI |
||
| GO:0009898 |
internal side of plasma membrane |
MGI:MGI:4462284 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016874 |
ligase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0436 |
F |
From MGI |
||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030163 |
protein catabolic process |
MGI:MGI:2680840 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
F |
From MGI |
||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
F |
From MGI |
||
| GO:0032743 |
positive regulation of interleukin-2 production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
P |
From MGI |
||
| GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034351 |
negative regulation of glial cell apoptotic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
P |
From MGI |
||
| GO:0035631 |
CD40 receptor complex |
MGI:MGI:4462284 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
C |
From MGI |
||
| GO:0043507 |
positive regulation of JUN kinase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043623 |
cellular protein complex assembly |
MGI:MGI:4462284 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
C |
From MGI |
||
| GO:0046328 |
regulation of JNK cascade |
MGI:MGI:2680840 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046625 |
sphingolipid binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0051023 |
regulation of immunoglobulin secretion |
MGI:MGI:2680840 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051091 |
positive regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
P |
From MGI |
||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051291 |
protein heterooligomerization |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001101285 |
P |
From MGI |
||
| GO:0051865 |
protein autoubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070207 |
protein homotrimerization |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0070534 |
protein K63-linked ubiquitination |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:2001238 |
positive regulation of extrinsic apoptotic signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Hostager BS et al. (2010) HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One 5: e11380 PubMed GONUTS page
- ↑ Arch RH & Thompson CB (1998) 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB. Mol Cell Biol 18: 558-65 PubMed GONUTS page
- ↑ 3.0 3.1 Gravestein LA et al. (1998) The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. Eur J Immunol 28: 2208-16 PubMed GONUTS page
- ↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
- ↑ Sanada T et al. (2008) FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem 283: 33858-64 PubMed GONUTS page
- ↑ Neely RJ et al. (2011) The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK. Oncogene 30: 87-96 PubMed GONUTS page
- ↑ Shembade N et al. (2011) The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol 12: 834-43 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page
