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MGI:Tpcn2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tpcn2 | |
| Protein Name(s) | two pore segment channel 2, | |
| External Links | ||
| MGI | MGI:2385297 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005216 |
ion channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0407 |
F |
From MGI |
||
| GO:0005216 |
ion channel activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005244 |
voltage-gated ion channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0851 |
F |
From MGI |
||
| GO:0005245 |
voltage-gated calcium channel activity |
MGI:MGI:5285159 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0005262 |
calcium channel activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0107 |
F |
From MGI |
||
| GO:0005764 |
lysosome |
MGI:MGI:5285159 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005765 |
lysosomal membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005765 |
lysosomal membrane |
MGI:MGI:5285171 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006810 |
transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0813 |
P |
From MGI |
||
| GO:0006811 |
ion transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0406 |
P |
From MGI |
||
| GO:0006811 |
ion transport |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006816 |
calcium ion transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0109 |
P |
From MGI |
||
| GO:0006874 |
cellular calcium ion homeostasis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006939 |
smooth muscle contraction |
MGI:MGI:4838733 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010008 |
endosome membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016020 |
membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0034765 |
regulation of ion transmembrane transport |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0851 |
P |
From MGI |
||
| GO:0042802 |
identical protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0051209 |
release of sequestered calcium ion into cytosol |
MGI:MGI:5285159 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0055085 |
transmembrane transport |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0072345 |
NAADP-sensitive calcium-release channel activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0072345 |
NAADP-sensitive calcium-release channel activity |
MGI:MGI:5285159 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0072345 |
NAADP-sensitive calcium-release channel activity |
MGI:MGI:5285171 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Schieder M et al. (2010) Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes. J Biol Chem 285: 21219-22 PubMed GONUTS page
- ↑ 2.0 2.1 Zong X et al. (2009) The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch 458: 891-9 PubMed GONUTS page
- ↑ Tugba Durlu-Kandilci N et al. (2010) TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem 285: 24925-32 PubMed GONUTS page
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