MGI:Tnf

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000060	protein import into nucleus, translocation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:1097308 PMID:9305915^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:5285024 PMID:21689636^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0000185	activation of MAPKKK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0001775	cell activation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0001819	positive regulation of cytokine production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0001891	phagocytic cup	MGI:MGI:3610792 PMID:16282525^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0001932	regulation of protein phosphorylation	MGI:MGI:3045683 PMID:15169905^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0002020	protease binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	F	From MGI
	GO:0002020	protease binding	MGI:MGI:4942254 PMID:12135759^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q05910	F	From MGI
	GO:0002037	negative regulation of L-glutamate transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0002439	chronic inflammatory response to antigenic stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0002740	negative regulation of cytokine secretion involved in immune response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus	MGI:MGI:3690573 PMID:9834074^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P	From MGI
	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	MGI:MGI:3690573 PMID:9834074^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2152007 PMID:11588035^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:2176422 PMID:11894098^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005125	cytokine activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:1095831 PMID:9256477^[9]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:1098089 PMID:9368616^[10]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:1203431 PMID:9565643^[11]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:2152007 PMID:11588035^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:53235 PMID:8387893^[12]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:59648 PMID:1645445^[13]	IPI: Inferred from Physical Interaction	UniProtKB:P25119 UniProtKB:P25118	F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:62592 PMID:8395024^[14]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:65999 PMID:8171322^[15]	TAS: Traceable Author Statement		F	From MGI
	GO:0005164	tumor necrosis factor receptor binding	MGI:MGI:894912 PMID:9223320^[16]	TAS: Traceable Author Statement		F	From MGI
	GO:0005515	protein binding	MGI:MGI:3624581 PMID:16702408^[17]	IPI: Inferred from Physical Interaction	UniProtKB:Q9QWL7	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1347429 PMID:10545106^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1861065 PMID:10899905^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:1930064 PMID:11168643^[20]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2176422 PMID:11894098^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2178646 PMID:10549626^[21]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2669022 PMID:12855817^[22]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:2670551 PMID:12872135^[23]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3029067 PMID:14764707^[24]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3050756 PMID:15220916^[25]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3510555 PMID:11728336^[26]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3608246 PMID:16236719^[27]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3611539 PMID:16239543^[28]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3695768 PMID:16275384^[29]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3761982 PMID:17693256^[30]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3775161 PMID:18261938^[31]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3823129 PMID:18997793^[32]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:49296 PMID:1577194^[33]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:3689241 PMID:17015619^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341850	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4358631 PMID:19723499^[35]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005622	intracellular	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:3050738 PMID:15155767^[36]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:1306673 PMID:8879212^[37]	TAS: Traceable Author Statement		C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	C	From MGI
	GO:0006006	glucose metabolic process	MGI:MGI:2181851 PMID:12068289^[38]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:3709926 PMID:17242187^[39]	IGI: Inferred from Genetic Interaction	MGI:MGI:97583	P	From MGI
	GO:0006915	apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4420852 PMID:20080598^[40]	IGI: Inferred from Genetic Interaction	MGI:MGI:1928487 MGI:MGI:1929004	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:67096 PMID:8208546^[41]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0006927	transformed cell apoptotic process	MGI:MGI:1098089 PMID:9368616^[10]	TAS: Traceable Author Statement		P	From MGI
	GO:0006927	transformed cell apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0006927	transformed cell apoptotic process	MGI:MGI:65999 PMID:8171322^[15]	TAS: Traceable Author Statement		P	From MGI
	GO:0006927	transformed cell apoptotic process	MGI:MGI:75691 PMID:7636227^[42]	TAS: Traceable Author Statement		P	From MGI
	GO:0006952	defense response	MGI:MGI:62592 PMID:8395024^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1861040	P	From MGI
	GO:0006952	defense response	MGI:MGI:894912 PMID:9223320^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860250	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:53235 PMID:8387893^[12]	TAS: Traceable Author Statement		P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:65999 PMID:8171322^[15]	TAS: Traceable Author Statement		P	From MGI
	GO:0006955	immune response	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006052 InterPro:IPR006053 InterPro:IPR002959	P	From MGI
	GO:0006959	humoral immune response	MGI:MGI:1306673 PMID:8879212^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0007254	JNK cascade	MGI:MGI:3689241 PMID:17015619^[34]	IGI: Inferred from Genetic Interaction	MGI:MGI:1341850	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1098089 PMID:9368616^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860953	P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:75691 PMID:7636227^[42]	TAS: Traceable Author Statement		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:65999 PMID:8171322^[15]	TAS: Traceable Author Statement		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0008624	induction of apoptosis by extracellular signals	MGI:MGI:3525895 PMID:15629131^[43]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008624	induction of apoptosis by extracellular signals	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0008625	induction of apoptosis via death domain receptors	MGI:MGI:3029504 PMID:12431371^[44]	IGI: Inferred from Genetic Interaction	MGI:MGI:1096330	P	From MGI
	GO:0008625	induction of apoptosis via death domain receptors	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0009615	response to virus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:1306673 PMID:8879212^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2149024	P	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:3610792 PMID:16282525^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009897	external side of plasma membrane	MGI:MGI:5013872 PMID:21606376^[45]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0009986	cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	C	From MGI
	GO:0010629	negative regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0010693	negative regulation of alkaline phosphatase activity	MGI:MGI:5285024 PMID:21689636^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016020	membrane	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR006052 InterPro:IPR006053 InterPro:IPR002959	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	C	From MGI
	GO:0019722	calcium-mediated signaling	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0030141	secretory granule	MGI:MGI:1306673 PMID:8879212^[37]	TAS: Traceable Author Statement		C	From MGI
	GO:0030198	extracellular matrix organization	MGI:MGI:3510270 PMID:15381731^[46]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030316	osteoclast differentiation	MGI:MGI:3525391 PMID:15485831^[47]	IGI: Inferred from Genetic Interaction	MGI:MGI:1100089 MGI:MGI:99484	P	From MGI
	GO:0030730	sequestering of triglyceride	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0031334	positive regulation of protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0031622	positive regulation of fever generation	MGI:MGI:4413614 PMID:19940926^[48]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0032715	negative regulation of interleukin-6 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0032722	positive regulation of chemokine production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0032729	positive regulation of interferon-gamma production	MGI:MGI:3690573 PMID:9834074^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P	From MGI
	GO:0032755	positive regulation of interleukin-6 production	MGI:MGI:2176422 PMID:11894098^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032800	receptor biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0033209	tumor necrosis factor-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0033209	tumor necrosis factor-mediated signaling pathway	MGI:MGI:63487 PMID:3898078^[49]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0034116	positive regulation of heterotypic cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:2176657 PMID:11799106^[50]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042346	positive regulation of NF-kappaB import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0042346	positive regulation of NF-kappaB import into nucleus	MGI:MGI:5285024 PMID:21689636^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042742	defense response to bacterium	MGI:MGI:1861065 PMID:10899905^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042802	identical protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	F	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043066	negative regulation of apoptotic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043068	positive regulation of programmed cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043122	regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3039643 PMID:12867038^[51]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3607973 PMID:16260493^[52]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:3607973 PMID:16260493^[52]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043243	positive regulation of protein complex disassembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043491	protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0043525	positive regulation of neuron apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0044130	negative regulation of growth of symbiont in host	MGI:MGI:3690573 PMID:9834074^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	F	From MGI
	GO:0045071	negative regulation of viral genome replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045080	positive regulation of chemokine biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:3828392 PMID:17010968^[53]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0045121	membrane raft	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	C	From MGI
	GO:0045123	cellular extravasation	MGI:MGI:2658799 PMID:10528208^[54]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045416	positive regulation of interleukin-8 biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045429	positive regulation of nitric oxide biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045668	negative regulation of osteoblast differentiation	MGI:MGI:5285024 PMID:21689636^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045670	regulation of osteoclast differentiation	MGI:MGI:2448204 PMID:12490655^[55]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045672	positive regulation of osteoclast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045840	positive regulation of mitosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3608448 PMID:12761567^[56]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:1097308 PMID:9305915^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3761912 PMID:17670746^[57]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3844151 PMID:19404405^[58]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4412460 PMID:18025219^[59]	IGI: Inferred from Genetic Interaction	MGI:MGI:107656	P	From MGI
	GO:0045994	positive regulation of translational initiation by iron	MGI:MGI:2152007 PMID:11588035^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046325	negative regulation of glucose import	MGI:MGI:2181851 PMID:12068289^[38]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046325	negative regulation of glucose import	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3607973 PMID:16260493^[52]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:3607973 PMID:16260493^[52]	IGI: Inferred from Genetic Interaction	MGI:MGI:1346877	P	From MGI
	GO:0046330	positive regulation of JNK cascade	MGI:MGI:4420852 PMID:20080598^[40]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048661	positive regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0050708	regulation of protein secretion	MGI:MGI:3848759 PMID:19293336^[60]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050715	positive regulation of cytokine secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0050796	regulation of insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0050806	positive regulation of synaptic transmission	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0050830	defense response to Gram-positive bacterium	MGI:MGI:3690573 PMID:9834074^[6]	IGI: Inferred from Genetic Interaction	MGI:MGI:104797	P	From MGI
	GO:0050900	leukocyte migration	MGI:MGI:3036957 PMID:15034066^[61]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050901	leukocyte tethering or rolling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0050995	negative regulation of lipid catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051023	regulation of immunoglobulin secretion	MGI:MGI:2680840 PMID:12958312^[62]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:3575325 PMID:15790681^[63]	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051222	positive regulation of protein transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P16599	P	From MGI
	GO:0051222	positive regulation of protein transport	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051384	response to glucocorticoid stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051533	positive regulation of NFAT protein import into nucleus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0051798	positive regulation of hair follicle development	MGI:MGI:3624581 PMID:16702408^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4420852 PMID:20080598^[40]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0055037	recycling endosome	MGI:MGI:3610792 PMID:16282525^[3]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0060555	induction of necroptosis by extracellular signals	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0060557	positive regulation of vitamin D biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	MGI:MGI:1931422 PMID:11241200^[64]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	MGI:MGI:1931422 PMID:11241200^[64]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060693	regulation of branching involved in salivary gland morphogenesis	MGI:MGI:1931422 PMID:11241200^[64]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0061048	negative regulation of branching involved in lung morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0070265	necrotic cell death	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0071230	cellular response to amino acid stimulus	MGI:MGI:4833768 PMID:20548288^[65]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071316	cellular response to nicotine	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0071803	positive regulation of podosome assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:0097191	extrinsic apoptotic signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:2000010	positive regulation of protein localization at cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01375	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem 272: 24514-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Tsukasaki M et al. (2011) Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α. Biochem Biophys Res Commun 410: 766-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Murray RZ et al. (2005) A role for the phagosome in cytokine secretion. Science 310: 1492-5 PubMed GONUTS page
↑ Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page
↑ Amour A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett 524: 154-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 161: 5937-42 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Carballo E & Blackshear PJ (2001) Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page
↑ Alimzhanov MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94: 9302-7 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Körner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-9 PubMed GONUTS page
↑ Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 187: 1517-28 PubMed GONUTS page
↑ ^12.0 ^12.1 Pfeffer K et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-67 PubMed GONUTS page
↑ Goodwin RG et al. (1991) Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol 11: 3020-6 PubMed GONUTS page
↑ ^14.0 ^14.1 Rothe J et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264: 703-7 PubMed GONUTS page
↑ ^16.0 ^16.1 Marino MW et al. (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A 94: 8093-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Tong X & Coulombe PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20: 1353-64 PubMed GONUTS page
↑ Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18: 5943-52 PubMed GONUTS page
↑ ^19.0 ^19.1 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page
↑ Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page
↑ Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page
↑ Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page
↑ Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page
↑ Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page
↑ Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page
↑ Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page
↑ Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page
↑ Kielian T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73: 7428-35 PubMed GONUTS page
↑ Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page
↑ Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page
↑ Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page
↑ Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9: 1347-55 PubMed GONUTS page
↑ De M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev Biol 151: 297-305 PubMed GONUTS page
↑ ^34.0 ^34.1 Gan B et al. (2006) Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175: 121-33 PubMed GONUTS page
↑ Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page
↑ Marchetti L et al. (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-81 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 Pasparakis M et al. (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184: 1397-411 PubMed GONUTS page
↑ ^38.0 ^38.1 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page
↑ Song L et al. (2007) p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation. Mol Cell Biol 27: 2713-31 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 Song H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107: 1431-6 PubMed GONUTS page
↑ Fernandez A et al. (1994) Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells. Oncogene 9: 2009-17 PubMed GONUTS page
↑ ^42.0 ^42.1 Banks TA et al. (1995) Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J Immunol 155: 1685-93 PubMed GONUTS page
↑ Hsu LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem Biophys Res Commun 327: 415-23 PubMed GONUTS page
↑ Datta SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell 3: 631-43 PubMed GONUTS page
↑ Day EB et al. (2011) Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A 108: 9536-41 PubMed GONUTS page
↑ Katakai T et al. (2004) Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med 200: 783-95 PubMed GONUTS page
↑ Chaisson ML et al. (2004) Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J Biol Chem 279: 54841-8 PubMed GONUTS page
↑ Hanada R et al. (2009) Central control of fever and female body temperature by RANKL/RANK. Nature 462: 505-9 PubMed GONUTS page
↑ Pennica D et al. (1985) Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor. Proc Natl Acad Sci U S A 82: 6060-4 PubMed GONUTS page
↑ Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
↑ Egawa T et al. (2003) Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol 13: 1252-8 PubMed GONUTS page
↑ ^52.0 ^52.1 ^52.2 ^52.3 Shim JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19: 2668-81 PubMed GONUTS page
↑ Tellier E et al. (2006) The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res 312: 3969-80 PubMed GONUTS page
↑ Ding ZM et al. (1999) Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration. J Immunol 163: 5029-38 PubMed GONUTS page
↑ Toraldo G et al. (2003) IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci U S A 100: 125-30 PubMed GONUTS page
↑ Abrantes EF et al. (2003) Identification, structural characterization, and tissue distribution of Tsg-5: a new TNF-stimulated gene. Genes Immun 4: 298-311 PubMed GONUTS page
↑ Yao D et al. (2007) High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A. J Biol Chem 282: 31038-45 PubMed GONUTS page
↑ Esteban V et al. (2009) Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. PLoS One 4: e5406 PubMed GONUTS page
↑ Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol 179: 7729-40 PubMed GONUTS page
↑ Fowler JD et al. (2009) Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 296: E1383-91 PubMed GONUTS page
↑ Young RE et al. (2004) Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 172: 4493-502 PubMed GONUTS page
↑ Hostager BS et al. (2003) Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling. J Biol Chem 278: 45382-90 PubMed GONUTS page
↑ Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 102: 5138-43 PubMed GONUTS page
↑ ^64.0 ^64.1 ^64.2 Melnick M et al. (2001) Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec 262: 318-30 PubMed GONUTS page
↑ Pogribny IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest 90: 1437-46 PubMed GONUTS page

[PMID:9305915-0] 1.0 ^1.1 Hadri KE et al. (1997) Differential regulation by tumor necrosis factor-alpha of beta1-, beta2-, and beta3-adrenoreceptor gene expression in 3T3-F442A adipocytes. J Biol Chem 272: 24514-21 PubMed GONUTS page

[PMID:21689636-1] 2.0 ^2.1 ^2.2 ^2.3 Tsukasaki M et al. (2011) Expression of POEM, a positive regulator of osteoblast differentiation, is suppressed by TNF-α. Biochem Biophys Res Commun 410: 766-70 PubMed GONUTS page

[PMID:16282525-2] 3.0 ^3.1 ^3.2 Murray RZ et al. (2005) A role for the phagosome in cytokine secretion. Science 310: 1492-5 PubMed GONUTS page

[PMID:15169905-3] Ueki K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-46 PubMed GONUTS page

[PMID:12135759-4] Amour A et al. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett 524: 154-8 PubMed GONUTS page

[PMID:9834074-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Hultgren O et al. (1998) TNF/lymphotoxin-alpha double-mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 161: 5937-42 PubMed GONUTS page

[PMID:11588035-6] 7.0 ^7.1 ^7.2 Carballo E & Blackshear PJ (2001) Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 98: 2389-95 PubMed GONUTS page

[PMID:11894098-7] 8.0 ^8.1 ^8.2 Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416: 194-9 PubMed GONUTS page

[PMID:9256477-8] Alimzhanov MB et al. (1997) Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A 94: 9302-7 PubMed GONUTS page

[PMID:9368616-9] 10.0 ^10.1 ^10.2 Körner H et al. (1997) Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27: 2600-9 PubMed GONUTS page

[PMID:9565643-10] Sean Riminton D et al. (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice. J Exp Med 187: 1517-28 PubMed GONUTS page

[PMID:8387893-11] 12.0 ^12.1 Pfeffer K et al. (1993) Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73: 457-67 PubMed GONUTS page

[PMID:1645445-12] Goodwin RG et al. (1991) Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol 11: 3020-6 PubMed GONUTS page

[PMID:8395024-13] 14.0 ^14.1 Rothe J et al. (1993) Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364: 798-802 PubMed GONUTS page

[PMID:8171322-14] 15.0 ^15.1 ^15.2 ^15.3 De Togni P et al. (1994) Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264: 703-7 PubMed GONUTS page

[PMID:9223320-15] 16.0 ^16.1 Marino MW et al. (1997) Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A 94: 8093-8 PubMed GONUTS page

[PMID:16702408-16] 17.0 ^17.1 Tong X & Coulombe PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion. Genes Dev 20: 1353-64 PubMed GONUTS page

[PMID:10545106-17] Xiao X et al. (1999) HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. EMBO J 18: 5943-52 PubMed GONUTS page

[PMID:10899905-18] 19.0 ^19.1 Fratazzi C et al. (2000) A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43. J Exp Med 192: 183-92 PubMed GONUTS page

[PMID:11168643-19] Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102: 103-13 PubMed GONUTS page

[PMID:10549626-20] Takeuchi O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-51 PubMed GONUTS page

[PMID:12855817-21] Yamamoto M et al. (2003) Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3 PubMed GONUTS page

[PMID:12872135-22] Hoebe K et al. (2003) Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424: 743-8 PubMed GONUTS page

[PMID:14764707-23] Sakurai D et al. (2004) Fc epsilon RI gamma-ITAM is differentially required for mast cell function in vivo. J Immunol 172: 2374-81 PubMed GONUTS page

[PMID:15220916-24] Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5: 800-8 PubMed GONUTS page

[PMID:11728336-25] Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15: 739-50 PubMed GONUTS page

[PMID:16236719-26] Negishi H et al. (2005) Negative regulation of Toll-like-receptor signaling by IRF-4. Proc Natl Acad Sci U S A 102: 15989-94 PubMed GONUTS page

[PMID:16239543-27] Kielian T et al. (2005) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73: 7428-35 PubMed GONUTS page

[PMID:16275384-28] Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol 116: 1106-15 PubMed GONUTS page

[PMID:17693256-29] Lee NK et al. (2007) Endocrine regulation of energy metabolism by the skeleton. Cell 130: 456-69 PubMed GONUTS page

[PMID:18261938-30] Kim YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28: 246-57 PubMed GONUTS page

[PMID:18997793-31] Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9: 1347-55 PubMed GONUTS page

[PMID:1577194-32] De M et al. (1992) Interleukin-1, interleukin-6, and tumor necrosis factor alpha are produced in the mouse uterus during the estrous cycle and are induced by estrogen and progesterone. Dev Biol 151: 297-305 PubMed GONUTS page

[PMID:17015619-33] 34.0 ^34.1 Gan B et al. (2006) Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. J Cell Biol 175: 121-33 PubMed GONUTS page

[PMID:19723499-34] Terauchi M et al. (2009) T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab 10: 229-40 PubMed GONUTS page

[PMID:15155767-35] Marchetti L et al. (2004) Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem 279: 32869-81 PubMed GONUTS page

[PMID:8879212-36] 37.0 ^37.1 ^37.2 ^37.3 Pasparakis M et al. (1996) Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184: 1397-411 PubMed GONUTS page

[PMID:12068289-37] 38.0 ^38.1 Maeda N et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-7 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Tnf ( synonyms: DIF, TNF alpha, TNF-alpha, Tnfa, TNFalpha, Tnfsf1a, tumor necrosis factor-alpha )
Protein Name(s)	tumor necrosis factor,
External Links
MGI	MGI:104798

MGI:Tnf

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