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MGI:Tmem173
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tmem173 ( synonyms: ERIS, MPYS, Sting ) | |
| Protein Name(s) | transmembrane protein 173, | |
| External Links | ||
| MGI | MGI:1919762 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0002218 |
activation of innate immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0002230 |
positive regulation of defense response to virus by host |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5291856 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005739 |
mitochondrion |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0496 |
C |
From MGI |
||
| GO:0005741 |
mitochondrial outer membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:5291856 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:4365649 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005789 |
endoplasmic reticulum membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006915 |
apoptotic process |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0053 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031625 |
ubiquitin protein ligase binding |
MGI:MGI:4849871 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0032092 |
positive regulation of protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032608 |
interferon-beta production |
MGI:MGI:3849536 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032608 |
interferon-beta production |
MGI:MGI:4365649 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032608 |
interferon-beta production |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0033160 |
positive regulation of protein import into nucleus, translocation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0035458 |
cellular response to interferon-beta |
MGI:MGI:5291856 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042993 |
positive regulation of transcription factor import into nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:3849536 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:4365649 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5291856 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:4365649 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:4365649 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0051607 |
defense response to virus |
MGI:MGI:5291856 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0071360 |
cellular response to exogenous dsRNA |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang Z et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat Immunol 12: 959-65 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Ishikawa H et al. (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461: 788-92 PubMed GONUTS page
- ↑ Tsuchida T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33: 765-76 PubMed GONUTS page
- ↑ 4.0 4.1 Sun W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A 106: 8653-8 PubMed GONUTS page
