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MGI:Tlr1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tlr1 | |
| Protein Name(s) | toll-like receptor 1, | |
| External Links | ||
| MGI | MGI:1341295 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004888 |
transmembrane signaling receptor activity |
MGI:MGI:3690171 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006952 |
defense response |
MGI:MGI:3526877 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3526882 |
P |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0395 |
P |
From MGI |
||
| GO:0006955 |
immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007165 |
signal transduction |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0007250 |
activation of NF-kappaB-inducing kinase activity |
MGI:MGI:3609367 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3690171 |
NAS: Non-traceable Author Statement |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0031224 |
intrinsic to membrane |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0968 |
C |
From MGI |
||
| GO:0035354 |
Toll-like receptor 1-Toll-like receptor 2 protein complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0042116 |
macrophage activation |
MGI:MGI:2653145 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0042495 |
detection of triacyl bacterial lipopeptide |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042495 |
detection of triacyl bacterial lipopeptide |
MGI:MGI:3609367 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0042497 |
triacyl lipopeptide binding |
MGI:MGI:3609367 |
NAS: Non-traceable Author Statement |
F |
From MGI |
|||
| GO:0042535 |
positive regulation of tumor necrosis factor biosynthetic process |
MGI:MGI:3609367 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045087 |
innate immune response |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0045335 |
phagocytic vesicle |
MGI:MGI:2653145 |
NAS: Non-traceable Author Statement |
C |
From MGI |
|||
| GO:0045410 |
positive regulation of interleukin-6 biosynthetic process |
MGI:MGI:3609367 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0071727 |
cellular response to triacyl bacterial lipopeptide |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Xu Y et al. (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408: 111-5 PubMed GONUTS page
- ↑ Alexopoulou L et al. (2002) Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med 8: 878-84 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Takeuchi O et al. (2002) Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 169: 10-4 PubMed GONUTS page
- ↑ 4.0 4.1 Ozinsky A et al. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 97: 13766-71 PubMed GONUTS page
