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MGI:Tjp1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tjp1 ( synonyms: ZO-1, ZO1 ) | |
| Protein Name(s) | tight junction protein 1, | |
| External Links | ||
| MGI | MGI:98759 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001825 |
blastocyst formation |
MGI:MGI:3797149 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1350677 |
IPI: Inferred from Physical Interaction |
UniProtKB:O35054 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:3607041 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3696587 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005516 |
calmodulin binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0112 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:3028421 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3615847 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3615847 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001099736 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2181897 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:2450087 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3574751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:3717054 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005911 |
cell-cell junction |
MGI:MGI:3797149 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005912 |
adherens junction |
MGI:MGI:2386382 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:2154851 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:3604842 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005913 |
cell-cell adherens junction |
MGI:MGI:3723326 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005921 |
gap junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0303 |
C |
From MGI |
||
| GO:0005923 |
tight junction |
MGI:MGI:1340945 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:1926537 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:2153620 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:2156129 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3028421 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3041908 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3574751 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3582101 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3610287 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3615847 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3616720 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3620435 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3688770 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3695521 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3696930 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3703395 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3723326 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3762993 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:3797995 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001099736 |
C |
From MGI |
||
| GO:0005923 |
tight junction |
MGI:MGI:4420836 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:4457791 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:4835639 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:4940123 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005923 |
tight junction |
MGI:MGI:5009409 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008022 |
protein C-terminus binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
NCBI:NP_001099736 |
F |
From MGI |
||
| GO:0009986 |
cell surface |
MGI:MGI:2450087 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3578587 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016323 |
basolateral plasma membrane |
MGI:MGI:3615847 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016327 |
apicolateral plasma membrane |
MGI:MGI:3620435 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:3723326 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:3615847 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:5295345 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0043296 |
apical junction complex |
MGI:MGI:3615847 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045177 |
apical part of cell |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0046581 |
intercellular canaliculus |
MGI:MGI:2181857 |
IDA: Inferred from Direct Assay |
C |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Wang H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 318: 112-25 PubMed GONUTS page
- ↑ Itoh M et al. (1999) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 147: 1351-63 PubMed GONUTS page
- ↑ Osler ME et al. (2005) Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci 118: 4667-78 PubMed GONUTS page
- ↑ Chen VC et al. (2006) Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. J Proteome Res 5: 2123-34 PubMed GONUTS page
- ↑ 5.0 5.1 Parkinson SJ et al. (2004) Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J 23: 77-88 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Lee NP et al. (2006) Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. FEBS Lett 580: 923-31 PubMed GONUTS page
- ↑ Morita K et al. (2002) Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. J Invest Dermatol 118: 1073-9 PubMed GONUTS page
- ↑ 8.0 8.1 Unda FJ et al. (2003) Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development. Histol Histopathol 18: 27-38 PubMed GONUTS page
- ↑ 9.0 9.1 Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page
- ↑ Mandal MN et al. (2006) CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 47: 5505-13 PubMed GONUTS page
- ↑ Manabe N et al. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn 225: 61-9 PubMed GONUTS page
- ↑ Pantaleon M et al. (2001) FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev 109: 151-60 PubMed GONUTS page
- ↑ Inagaki M et al. (2005) Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development 132: 1525-37 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Etournay R et al. (2007) Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci 120: 2838-50 PubMed GONUTS page
- ↑ Kidson SH et al. (1999) The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol 211: 306-22 PubMed GONUTS page
- ↑ Sheth B et al. (2000) Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mech Dev 97: 93-104 PubMed GONUTS page
- ↑ Miyoshi K et al. (2001) Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol 155: 531-42 PubMed GONUTS page
- ↑ Hamazaki Y et al. (2002) Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem 277: 455-61 PubMed GONUTS page
- ↑ Inoko A et al. (2003) Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues. Genes Cells 8: 837-45 PubMed GONUTS page
- ↑ Vinot S et al. (2005) Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol 282: 307-19 PubMed GONUTS page
- ↑ Hyenne V et al. (2005) Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Dev Biol 287: 180-91 PubMed GONUTS page
- ↑ Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
- ↑ 23.0 23.1 Ohta H et al. (2006) Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci 68: 149-55 PubMed GONUTS page
- ↑ Naim E et al. (2005) Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int 68: 955-65 PubMed GONUTS page
- ↑ Kan NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134: 31-41 PubMed GONUTS page
- ↑ Adachi M et al. (2006) Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol 26: 9003-15 PubMed GONUTS page
- ↑ Bort R et al. (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol 290: 44-56 PubMed GONUTS page
- ↑ Sugihara-Mizuno Y et al. (2007) Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells 12: 473-86 PubMed GONUTS page
- ↑ Rabionet M et al. (2008) Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283: 13357-69 PubMed GONUTS page
- ↑ Ikenouchi J & Umeda M (2010) FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A 107: 748-53 PubMed GONUTS page
- ↑ Gao N & Kaestner KH (2010) Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev 24: 1295-305 PubMed GONUTS page
- ↑ Zheng Y et al. (2009) Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Circ Res 105: 260-70 PubMed GONUTS page
- ↑ Blitzer AL et al. (2011) Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc Natl Acad Sci U S A 108: 2819-24 PubMed GONUTS page
- ↑ Rinehart J et al. (2005) WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A 102: 16777-82 PubMed GONUTS page
- ↑ Strumpf D et al. (2005) Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132: 2093-102 PubMed GONUTS page
- ↑ Akashi M et al. (2011) A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Biochem Biophys Res Commun 413: 224-9 PubMed GONUTS page
- ↑ Kikuchi S et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31: 320-5 PubMed GONUTS page