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MGI:Tjp1

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Tjp1 ( synonyms: ZO-1, ZO1 )
Protein Name(s) tight junction protein 1,
External Links
MGI MGI:98759

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001825

blastocyst formation

MGI:MGI:3797149
PMID:18423437[1]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0005515

protein binding

MGI:MGI:1350677
PMID:10601346[2]

IPI: Inferred from Physical Interaction

UniProtKB:O35054
UniProtKB:O54942
UniProtKB:O88551
UniProtKB:O88552
UniProtKB:Q9Z0G9
UniProtKB:Q9Z260
UniProtKB:Q9Z261
UniProtKB:Q9Z262

F

From MGI

GO:0005515

protein binding

MGI:MGI:3607041
PMID:16188940[3]

IPI: Inferred from Physical Interaction

UniProtKB:Q9ES83

F

From MGI

GO:0005515

protein binding

MGI:MGI:3696587
PMID:16944923[4]

IPI: Inferred from Physical Interaction

UniProtKB:P57780

F

From MGI

GO:0005516

calmodulin binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0112

F

From MGI

GO:0005634

nucleus

MGI:MGI:3028421
PMID:14685273[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:3615847
PMID:16427635[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:3615847
PMID:16427635[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001099736

C

From MGI

GO:0005737

cytoplasm

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0005794

Golgi apparatus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2181897
PMID:12060405[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:2450087
PMID:12507281[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3574751
PMID:15775979[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:3717054
PMID:17122142[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005886

plasma membrane

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0005911

cell-cell junction

MGI:MGI:3797149
PMID:18423437[1]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005912

adherens junction

MGI:MGI:2386382
PMID:12203721[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:2154851
PMID:11731229[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3604842
PMID:15728677[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005913

cell-cell adherens junction

MGI:MGI:3723326
PMID:17666436[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005921

gap junction

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0303

C

From MGI

GO:0005923

tight junction

MGI:MGI:1340945
PMID:10395790[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:1926537
PMID:11025210[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:2153620
PMID:11706048[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0005923

tight junction

MGI:MGI:2156129
PMID:11689568[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3028421
PMID:14685273[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3041908
PMID:14622136[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3574751
PMID:15775979[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3582101
PMID:15950600[20]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3610287
PMID:16199027[21]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3615847
PMID:16427635[6]

ISO: Inferred from Sequence Orthology

UniProtKB:O97758

C

From MGI

GO:0005923

tight junction

MGI:MGI:3616720
PMID:16510873[22]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3620435
PMID:16520537[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3688770
PMID:16105026[24]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3695521
PMID:17138661[25]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3696930
PMID:17000770[26]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3703395
PMID:16364283[27]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3723326
PMID:17666436[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3762993
PMID:17397395[28]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:3797995
PMID:18308723[29]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001099736

C

From MGI

GO:0005923

tight junction

MGI:MGI:4420836
PMID:20080746[30]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:4457791
PMID:20551175[31]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:4835639
PMID:19590046[32]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:4940123
PMID:21285373[33]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005923

tight junction

MGI:MGI:5009409
PMID:16275913[34]

IDA: Inferred from Direct Assay

C

From MGI

GO:0008022

protein C-terminus binding

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_001099736

F

From MGI

GO:0009986

cell surface

MGI:MGI:2450087
PMID:12507281[8]

ISO: Inferred from Sequence Orthology

UniProtKB:O97758

C

From MGI

GO:0016020

membrane

MGI:MGI:3578587
PMID:15788452[35]

IDA: Inferred from Direct Assay

C

From MGI

GO:0016323

basolateral plasma membrane

MGI:MGI:3615847
PMID:16427635[6]

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0016327

apicolateral plasma membrane

MGI:MGI:3620435
PMID:16520537[23]

IDA: Inferred from Direct Assay

C

From MGI

GO:0019904

protein domain specific binding

MGI:MGI:3723326
PMID:17666436[14]

IPI: Inferred from Physical Interaction

UniProtKB:A2ALU4

F

From MGI

GO:0030054

cell junction

MGI:MGI:3615847
PMID:16427635[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0030054

cell junction

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0030054

cell junction

MGI:MGI:5295345
PMID:21884682[36]

IDA: Inferred from Direct Assay

C

From MGI

GO:0043296

apical junction complex

MGI:MGI:3615847
PMID:16427635[6]

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0045177

apical part of cell

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q07157

C

From MGI

GO:0046581

intercellular canaliculus

MGI:MGI:2181857
PMID:12068294[37]

IDA: Inferred from Direct Assay

C

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Wang H et al. (2008) Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol 318: 112-25 PubMed GONUTS page
  2. Itoh M et al. (1999) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol 147: 1351-63 PubMed GONUTS page
  3. Osler ME et al. (2005) Bves modulates epithelial integrity through an interaction at the tight junction. J Cell Sci 118: 4667-78 PubMed GONUTS page
  4. Chen VC et al. (2006) Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. J Proteome Res 5: 2123-34 PubMed GONUTS page
  5. 5.0 5.1 Parkinson SJ et al. (2004) Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J 23: 77-88 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Lee NP et al. (2006) Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease. FEBS Lett 580: 923-31 PubMed GONUTS page
  7. Morita K et al. (2002) Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis. J Invest Dermatol 118: 1073-9 PubMed GONUTS page
  8. 8.0 8.1 Unda FJ et al. (2003) Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development. Histol Histopathol 18: 27-38 PubMed GONUTS page
  9. 9.0 9.1 Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24: 1146-56 PubMed GONUTS page
  10. Mandal MN et al. (2006) CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Invest Ophthalmol Vis Sci 47: 5505-13 PubMed GONUTS page
  11. Manabe N et al. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn 225: 61-9 PubMed GONUTS page
  12. Pantaleon M et al. (2001) FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev 109: 151-60 PubMed GONUTS page
  13. Inagaki M et al. (2005) Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development 132: 1525-37 PubMed GONUTS page
  14. 14.0 14.1 14.2 Etournay R et al. (2007) Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci 120: 2838-50 PubMed GONUTS page
  15. Kidson SH et al. (1999) The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. Dev Biol 211: 306-22 PubMed GONUTS page
  16. Sheth B et al. (2000) Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mech Dev 97: 93-104 PubMed GONUTS page
  17. Miyoshi K et al. (2001) Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol 155: 531-42 PubMed GONUTS page
  18. Hamazaki Y et al. (2002) Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem 277: 455-61 PubMed GONUTS page
  19. Inoko A et al. (2003) Expression and distribution of ZO-3, a tight junction MAGUK protein, in mouse tissues. Genes Cells 8: 837-45 PubMed GONUTS page
  20. Vinot S et al. (2005) Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol 282: 307-19 PubMed GONUTS page
  21. Hyenne V et al. (2005) Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Dev Biol 287: 180-91 PubMed GONUTS page
  22. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev 20: 571-85 PubMed GONUTS page
  23. 23.0 23.1 Ohta H et al. (2006) Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. J Vet Med Sci 68: 149-55 PubMed GONUTS page
  24. Naim E et al. (2005) Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney. Kidney Int 68: 955-65 PubMed GONUTS page
  25. Kan NG et al. (2007) Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development 134: 31-41 PubMed GONUTS page
  26. Adachi M et al. (2006) Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein. Mol Cell Biol 26: 9003-15 PubMed GONUTS page
  27. Bort R et al. (2006) Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development. Dev Biol 290: 44-56 PubMed GONUTS page
  28. Sugihara-Mizuno Y et al. (2007) Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Genes Cells 12: 473-86 PubMed GONUTS page
  29. Rabionet M et al. (2008) Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J Biol Chem 283: 13357-69 PubMed GONUTS page
  30. Ikenouchi J & Umeda M (2010) FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc Natl Acad Sci U S A 107: 748-53 PubMed GONUTS page
  31. Gao N & Kaestner KH (2010) Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev 24: 1295-305 PubMed GONUTS page
  32. Zheng Y et al. (2009) Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Circ Res 105: 260-70 PubMed GONUTS page
  33. Blitzer AL et al. (2011) Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc Natl Acad Sci U S A 108: 2819-24 PubMed GONUTS page
  34. Rinehart J et al. (2005) WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A 102: 16777-82 PubMed GONUTS page
  35. Strumpf D et al. (2005) Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132: 2093-102 PubMed GONUTS page
  36. Akashi M et al. (2011) A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions. Biochem Biophys Res Commun 413: 224-9 PubMed GONUTS page
  37. Kikuchi S et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet 31: 320-5 PubMed GONUTS page
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