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MGI:Titf1
From GONUTS
Mus musculus (house mouse)
GO:0003677_!_DNA_binding (F) IEA with/from SP_KW:KW-0238,SP_KW:KW-0371 [2]
GO:0003677_!_DNA_binding (F) IEA with/from InterPro:IPR012287 [3]
GO:0003700_!_transcription_factor_activity (F) TAS [4]
GO:0003700_!_transcription_factor_activity (F) IDA [5]
GO:0003700_!_transcription_factor_activity (F) TAS [6]
GO:0005515_!_protein_binding (F) IPI with/from UniProt:Q61169 [5]
GO:0005515_!_protein_binding (F) IPI with/from UniProt:Q99K14 [7]
GO:0005634_!_nucleus (C) IDA [8]
GO:0005634_!_nucleus (C) IDA [9]
GO:0005667_!_transcription_factor_complex (C) IDA [5]
GO:0005667_!_transcription_factor_complex (C) IDA [7]
GO:0006350_!_transcription (P) IEA with/from SP_KW:KW-0804 [2]
GO:0006355_!_regulation_of_transcription,_DNA-dependent (P) IDA [5]
GO:0007389_!_pattern_specification (P) IGI with/from MGI:MGI:95843 [10]
GO:0007420_!_brain_development (P) IGI with/from MGI:MGI:95843 [10]
GO:0007420_!_brain_development (P) IMP with/from MGI:MGI:1857494 [6]
GO:0007492_!_endoderm_development (P) IMP with/from MGI:MGI:1857494 [4]
GO:0007492_!_endoderm_development (P) IMP with/from MGI:MGI:1857494 [6]
GO:0009887_!_organ_morphogenesis (P) IMP with/from MGI:MGI:1857494 [6]
GO:0016563_!_transcription_activator_activity (F) ISS with/from UniProt:P23441 [11]
GO:0021798_!_forebrain_dorsal-ventral_pattern_formation (P) IMP with/from MGI:MGI:1857494 [12]
GO:0030324_!_lung_development (P) IMP with/from MGI:MGI:1857494 [13]
GO:0030324_!_lung_development (P) IMP with/from MGI:MGI:2677488 [8]
GO:0030528_!_transcription_regulator_activity (F) IDA [7]
GO:0030528_!_transcription_regulator_activity (F) IGI with/from MGI:MGI:1917649 [7]
GO:0030878_!_thyroid_gland_development (P) IMP with/from MGI:MGI:1857494 [14]
GO:0043565_!_sequence-specific_DNA_binding (F) IEA with/from InterPro:IPR001356 [3]
GO:0045449_!_regulation_of_transcription (P) IEA with/from InterPro:IPR012287 [3]
GO:0045944_!_positive_regulation_of_transcription_from_RNA_polymerase_II_promoter (P) IDA [7]
GO:0045944_!_positive_regulation_of_transcription_from_RNA_polymerase_II_promoter (P) ISS with/from UniProt:P23441 [11]
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Titf1:thyroid transcription factor 1
Synonyms:Nkx2-1, Nkx2.1, T/EBP, thyroid-specific enhancer-binding protein, tinman, Ttf-1
Titf1 on MGI
GO terms
GO:0001764_!_neuron_migration (P) IMP with/from MGI:MGI:1857494 [1]GO:0003677_!_DNA_binding (F) IEA with/from SP_KW:KW-0238,SP_KW:KW-0371 [2]
GO:0003677_!_DNA_binding (F) IEA with/from InterPro:IPR012287 [3]
GO:0003700_!_transcription_factor_activity (F) TAS [4]
GO:0003700_!_transcription_factor_activity (F) IDA [5]
GO:0003700_!_transcription_factor_activity (F) TAS [6]
GO:0005515_!_protein_binding (F) IPI with/from UniProt:Q61169 [5]
GO:0005515_!_protein_binding (F) IPI with/from UniProt:Q99K14 [7]
GO:0005634_!_nucleus (C) IDA [8]
GO:0005634_!_nucleus (C) IDA [9]
GO:0005667_!_transcription_factor_complex (C) IDA [5]
GO:0005667_!_transcription_factor_complex (C) IDA [7]
GO:0006350_!_transcription (P) IEA with/from SP_KW:KW-0804 [2]
GO:0006355_!_regulation_of_transcription,_DNA-dependent (P) IDA [5]
GO:0007389_!_pattern_specification (P) IGI with/from MGI:MGI:95843 [10]
GO:0007420_!_brain_development (P) IGI with/from MGI:MGI:95843 [10]
GO:0007420_!_brain_development (P) IMP with/from MGI:MGI:1857494 [6]
GO:0007492_!_endoderm_development (P) IMP with/from MGI:MGI:1857494 [4]
GO:0007492_!_endoderm_development (P) IMP with/from MGI:MGI:1857494 [6]
GO:0009887_!_organ_morphogenesis (P) IMP with/from MGI:MGI:1857494 [6]
GO:0016563_!_transcription_activator_activity (F) ISS with/from UniProt:P23441 [11]
GO:0021798_!_forebrain_dorsal-ventral_pattern_formation (P) IMP with/from MGI:MGI:1857494 [12]
GO:0030324_!_lung_development (P) IMP with/from MGI:MGI:1857494 [13]
GO:0030324_!_lung_development (P) IMP with/from MGI:MGI:2677488 [8]
GO:0030528_!_transcription_regulator_activity (F) IDA [7]
GO:0030528_!_transcription_regulator_activity (F) IGI with/from MGI:MGI:1917649 [7]
GO:0030878_!_thyroid_gland_development (P) IMP with/from MGI:MGI:1857494 [14]
GO:0043565_!_sequence-specific_DNA_binding (F) IEA with/from InterPro:IPR001356 [3]
GO:0045449_!_regulation_of_transcription (P) IEA with/from InterPro:IPR012287 [3]
GO:0045944_!_positive_regulation_of_transcription_from_RNA_polymerase_II_promoter (P) IDA [7]
GO:0045944_!_positive_regulation_of_transcription_from_RNA_polymerase_II_promoter (P) ISS with/from UniProt:P23441 [11]
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Nery S et al. (2003) Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon. Cereb Cortex 13: 895-903 PubMed GONUTS page
- ↑ 2.0 2.1 MGI annotation MGI:1354194
- ↑ 3.0 3.1 3.2 MGI annotation MGI:2152098
- ↑ 4.0 4.1 Minoo P et al. (1999) Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Dev Biol 209: 60-71 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Liu C et al. (2002) GATA-6 and thyroid transcription factor-1 directly interact and regulate surfactant protein-C gene expression. J Biol Chem 277: 4519-25 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Kimura S et al. (1996) The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev 10: 60-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 Park KS et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem 279: 17384-90 PubMed GONUTS page
- ↑ 8.0 8.1 DeFelice M et al. (2003) TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression. J Biol Chem 278: 35574-83 PubMed GONUTS page
- ↑ Serls AE et al. (2005) Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung. Development 132: 35-47 PubMed GONUTS page
- ↑ 10.0 10.1 Corbin JG et al. (2003) Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning. Development 130: 4895-906 PubMed GONUTS page
- ↑ 11.0 11.1 Zannini M et al. (1997) TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation. EMBO J 16: 3185-97 PubMed GONUTS page
- ↑ Sussel L et al. (1999) Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development 126: 3359-70 PubMed GONUTS page
- ↑ Yuan B et al. (2000) Inhibition of distal lung morphogenesis in Nkx2.1(-/-) embryos. Dev Dyn 217: 180-90 PubMed GONUTS page
- ↑ Parlato R et al. (2004) An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol 276: 464-75 PubMed GONUTS page
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