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MGI:Timp2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Timp2 ( synonyms: D11Bwg1104e, TIMP-2 ) | |
| Protein Name(s) | tissue inhibitor of metalloproteinase 2, | |
| External Links | ||
| MGI | MGI:98753 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005178 |
integrin binding |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005178 |
integrin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005604 |
basement membrane |
MGI:MGI:2675517 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008047 |
enzyme activator activity |
MGI:MGI:1888586 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1888708 |
F |
From MGI |
||
| GO:0008047 |
enzyme activator activity |
MGI:MGI:1888587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1888709 |
F |
From MGI |
||
| GO:0008191 |
metalloendopeptidase inhibitor activity |
MGI:MGI:1888586 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0008191 |
metalloendopeptidase inhibitor activity |
MGI:MGI:1888587 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1888709 |
F |
From MGI |
||
| GO:0008191 |
metalloendopeptidase inhibitor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008285 |
negative regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010951 |
negative regulation of endopeptidase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030426 |
growth cone |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0030814 |
regulation of cAMP metabolic process |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0032487 |
regulation of Rap protein signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043005 |
neuron projection |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043025 |
neuronal cell body |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043408 |
regulation of MAPK cascade |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045664 |
regulation of neuron differentiation |
MGI:MGI:3578612 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045664 |
regulation of neuron differentiation |
MGI:MGI:3578612 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045666 |
positive regulation of neuron differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045762 |
positive regulation of adenylate cyclase activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045861 |
negative regulation of proteolysis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045930 |
negative regulation of mitotic cell cycle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046580 |
negative regulation of Ras protein signal transduction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071310 |
cellular response to organic substance |
MGI:MGI:3027475 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
|
NOT |
GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Pérez-Martínez L & Jaworski DM (2005) Tissue inhibitor of metalloproteinase-2 promotes neuronal differentiation by acting as an anti-mitogenic signal. J Neurosci 25: 4917-29 PubMed GONUTS page
- ↑ Yoshiba N et al. (2003) Temporospatial gene expression and protein localization of matrix metalloproteinases and their inhibitors during mouse molar tooth development. Dev Dyn 228: 105-12 PubMed GONUTS page
- ↑ 3.0 3.1 Wang Z et al. (2000) TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem 275: 26411-5 PubMed GONUTS page
- ↑ 4.0 4.1 Caterina JJ et al. (2000) Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation. J Biol Chem 275: 26416-22 PubMed GONUTS page
- ↑ Nishino K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ 44: 35-43 PubMed GONUTS page
