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MGI:Timeless

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Timeless ( synonyms: tim )
Protein Name(s) timeless homolog (Drosophila),
External Links
MGI MGI:1321393

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

MGI:MGI:1330981
PMID:9988221[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000790

nuclear chromatin

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9UNS1

C

From MGI

GO:0001658

branching involved in ureteric bud morphogenesis

MGI:MGI:2154458

ISO: Inferred from Sequence Orthology

UniProtKB:Q9Z2Y1

P

From MGI

GO:0001658

branching involved in ureteric bud morphogenesis

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112630

P

From MGI

GO:0001822

kidney development

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112630

P

From MGI

GO:0005515

protein binding

MGI:MGI:1316573
PMID:9856465[2]

IPI: Inferred from Physical Interaction

UniProtKB:O35973
UniProtKB:O54943

F

From MGI

GO:0005515

protein binding

MGI:MGI:1344065
PMID:10231394[3]

IPI: Inferred from Physical Interaction

UniProtKB:O35973

F

From MGI

GO:0005634

nucleus

MGI:MGI:2668796
PMID:12875843[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:2675515
PMID:12950082[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0005634

nucleus

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112630

C

From MGI

GO:0005634

nucleus

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9UNS1

C

From MGI

GO:0006351

transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From MGI

GO:0006355

regulation of transcription, DNA-dependent

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From MGI

GO:0006974

response to DNA damage stimulus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0227

P

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007067

mitosis

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

From MGI

GO:0007275

multicellular organismal development

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

From MGI

GO:0009790

embryo development

MGI:MGI:1861356
PMID:10903565[6]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3051143

P

From MGI

GO:0030324

lung development

MGI:MGI:2675515
PMID:12950082[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0033261

regulation of S phase

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9UNS1

P

From MGI

GO:0042753

positive regulation of circadian rhythm

MGI:MGI:4417868

ISO: Inferred from Sequence Orthology

NCBI:NP_112630

P

From MGI

GO:0042803

protein homodimerization activity

MGI:MGI:2668796
PMID:12875843[4]

IDA: Inferred from Direct Assay

F

From MGI

GO:0045892

negative regulation of transcription, DNA-dependent

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q9UNS1

P

From MGI

GO:0046982

protein heterodimerization activity

MGI:MGI:1344065
PMID:10231394[3]

IDA: Inferred from Direct Assay

F

From MGI

GO:0048511

rhythmic process

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0090

P

From MGI

GO:0048754

branching morphogenesis of a tube

MGI:MGI:2675515
PMID:12950082[5]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0051301

cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Dunlap JC (1999) Molecular bases for circadian clocks. Cell 96: 271-90 PubMed GONUTS page
  2. Sangoram AM et al. (1998) Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron 21: 1101-13 PubMed GONUTS page
  3. 3.0 3.1 Takumi T et al. (1999) A mammalian ortholog of Drosophila timeless, highly expressed in SCN and retina, forms a complex with mPER1. Genes Cells 4: 67-75 PubMed GONUTS page
  4. 4.0 4.1 Gotter AL (2003) Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. J Mol Biol 331: 167-76 PubMed GONUTS page
  5. 5.0 5.1 5.2 Xiao J et al. (2003) Timeless in lung morphogenesis. Dev Dyn 228: 82-94 PubMed GONUTS page
  6. Gotter AL et al. (2000) A time-less function for mouse timeless. Nat Neurosci 3: 755-6 PubMed GONUTS page
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