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MGI:Ticam2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Ticam2 ( synonyms: Tirp, TRAM ) | |
| Protein Name(s) | toll-like receptor adaptor molecule 2, | |
| External Links | ||
| MGI | MGI:3040056 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001817 |
regulation of cytokine production |
MGI:MGI:2679164 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040182 |
P |
From MGI |
||
| GO:0004871 |
signal transducer activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005149 |
interleukin-1 receptor binding |
MGI:MGI:2667507 |
ISA: Inferred from Sequence Alignment |
protein_id:AAP81748 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4942247 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0963 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0333 |
C |
From MGI |
||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0006954 |
inflammatory response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0395 |
P |
From MGI |
||
| GO:0007165 |
signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0043122 |
regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:2667507 |
ISA: Inferred from Sequence Alignment |
protein_id:AAP81748 |
P |
From MGI |
||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045087 |
innate immune response |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0399 |
P |
From MGI |
||
| GO:0045323 |
interleukin-1 receptor complex |
MGI:MGI:2667507 |
ISA: Inferred from Sequence Alignment |
protein_id:AAP81748 |
C |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:2667507 |
ISA: Inferred from Sequence Alignment |
protein_id:AAP81748 |
F |
From MGI |
||
|
NOT |
GO:0045357 |
regulation of interferon-beta biosynthetic process |
MGI:MGI:2667507 |
ISA: Inferred from Sequence Alignment |
protein_id:AAP81748 |
P |
From MGI |
|
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yamamoto M et al. (2003) TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol 4: 1144-50 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Bin LH et al. (2003) TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem 278: 24526-32 PubMed GONUTS page
- ↑ Fitzgerald KA et al. (2003) LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med 198: 1043-55 PubMed GONUTS page
