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MGI:Thrb
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Thrb ( synonyms: c-erbAbeta, Nr1a2, T3R(b), T3Rbeta, Thrb1, Thrb2, TR beta ) | |
| Protein Name(s) | thyroid hormone receptor beta, | |
| External Links | ||
| MGI | MGI:98743 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:76569 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1349717 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003690 |
double-stranded DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1330488 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003707 |
steroid hormone receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:1096733 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:1316795 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:1330488 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:1342162 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:1860435 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1202631 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3820333 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1096733 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1316795 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1330488 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1342162 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1330488 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1096733 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1316795 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1330488 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1342162 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1860435 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3820333 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1349717 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:1860435 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860434 |
P |
From MGI |
||
| GO:0007621 |
negative regulation of female receptivity |
MGI:MGI:1355641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860434 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:1316795 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0008050 |
female courtship behavior |
MGI:MGI:1355641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860441 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:1330488 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860407 |
P |
From MGI |
||
| GO:0019216 |
regulation of lipid metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019899 |
enzyme binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0031490 |
chromatin DNA binding |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0032332 |
positive regulation of chondrocyte differentiation |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0045778 |
positive regulation of ossification |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3028428 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3624051 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1346317 |
P |
From MGI |
||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0090181 |
regulation of cholesterol metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0090207 |
regulation of triglyceride metabolic process |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hörlein AJ et al. (1995) Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377: 397-404 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gauthier K et al. (1999) Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J 18: 623-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Weiss RE et al. (1997) Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice. Endocrinology 138: 3624-9 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Weiss RE et al. (1998) Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice. Endocrinology 139: 4945-52 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Abel ED et al. (1999) Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest 104: 291-300 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Forrest D et al. (1996) Thyroid hormone receptor beta is essential for development of auditory function. Nat Genet 13: 354-7 PubMed GONUTS page
- ↑ Zamir I et al. (1997) Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proc Natl Acad Sci U S A 94: 14400-5 PubMed GONUTS page
- ↑ 8.0 8.1 Astapova I et al. (2008) The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo. Proc Natl Acad Sci U S A 105: 19544-9 PubMed GONUTS page
- ↑ 9.0 9.1 Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci 10: 1414-22 PubMed GONUTS page
- ↑ 10.0 10.1 Dellovade TL et al. (2000) The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors. Nat Neurosci 3: 472-5 PubMed GONUTS page
- ↑ Eckey M et al. (2003) Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Mol Cell Endocrinol 213: 71-8 PubMed GONUTS page
- ↑ Yanagi Y et al. (2002) Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development. Invest Ophthalmol Vis Sci 43: 3489-94 PubMed GONUTS page
