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MGI:Thra
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Thra ( synonyms: c-erbAalpha, Erba, Nr1a1, Rvr, T3R(a), T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2 ) | |
| Protein Name(s) | thyroid hormone receptor alpha, | |
| External Links | ||
| MGI | MGI:98742 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001071 |
nucleic acid binding transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001502 |
cartilage condensation |
MGI:MGI:894529 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860442 |
P |
From MGI |
||
| GO:0001503 |
ossification |
MGI:MGI:1330488 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860407 |
P |
From MGI |
||
| GO:0001503 |
ossification |
MGI:MGI:894529 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860442 |
P |
From MGI |
||
| GO:0002153 |
steroid receptor RNA activator RNA binding |
MGI:MGI:3050934 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0002155 |
regulation of thyroid hormone mediated signaling pathway |
MGI:MGI:2677074 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2679056 |
P |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003707 |
steroid hormone receptor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0003727 |
single-stranded RNA binding |
MGI:MGI:3050934 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003727 |
single-stranded RNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0004879 |
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:3512848 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0004887 |
thyroid hormone receptor activity |
MGI:MGI:894529 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2152471 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3512848 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3619869 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005739 |
mitochondrion |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005829 |
cytosol |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR008946 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:894529 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006366 |
transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007611 |
learning or memory |
MGI:MGI:3829154 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860442 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:1195830 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860441 |
P |
From MGI |
||
| GO:0008016 |
regulation of heart contraction |
MGI:MGI:3047216 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2183135 |
P |
From MGI |
||
| GO:0008050 |
female courtship behavior |
MGI:MGI:1355641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860441 |
P |
From MGI |
||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0009409 |
response to cold |
MGI:MGI:2677074 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2679056 |
P |
From MGI |
||
| GO:0009755 |
hormone-mediated signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009887 |
organ morphogenesis |
MGI:MGI:1330488 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860407 |
P |
From MGI |
||
| GO:0010831 |
positive regulation of myotube differentiation |
MGI:MGI:3619869 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0017025 |
TBP-class protein binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0017055 |
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030218 |
erythrocyte differentiation |
MGI:MGI:3776707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860442 |
P |
From MGI |
||
| GO:0030878 |
thyroid gland development |
MGI:MGI:2156109 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97492 |
P |
From MGI |
||
| GO:0031490 |
chromatin DNA binding |
MGI:MGI:3771455 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0032403 |
protein complex binding |
MGI:MGI:3055270 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0033032 |
regulation of myeloid cell apoptotic process |
MGI:MGI:3776707 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860442 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042994 |
cytoplasmic sequestering of transcription factor |
MGI:MGI:3619869 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043401 |
steroid hormone mediated signaling pathway |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0043433 |
negative regulation of sequence-specific DNA binding transcription factor activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0044213 |
intronic transcription regulatory region DNA binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2152471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:2152471 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3028428 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3512848 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045925 |
positive regulation of female receptivity |
MGI:MGI:1355641 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1860441 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3055270 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050994 |
regulation of lipid catabolic process |
MGI:MGI:2677074 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2679056 |
P |
From MGI |
||
| GO:0070324 |
thyroid hormone binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070324 |
thyroid hormone binding |
MGI:MGI:66137 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:2000143 |
negative regulation of transcription initiation, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0003677 |
DNA binding |
MGI:MGI:3619869 |
IDA: Inferred from Direct Assay |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Fraichard A et al. (1997) The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production. EMBO J 16: 4412-20 PubMed GONUTS page
- ↑ 2.0 2.1 Gauthier K et al. (1999) Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J 18: 623-31 PubMed GONUTS page
- ↑ 3.0 3.1 Xu B & Koenig RJ (2004) An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation. J Biol Chem 279: 33051-6 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Liu YY et al. (2003) A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem 278: 38913-20 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem 279: 48329-41 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Potter GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev 15: 2687-701 PubMed GONUTS page
- ↑ 7.0 7.1 Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci 10: 1414-22 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Casas F et al. (2006) Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation. Mol Endocrinol 20: 749-63 PubMed GONUTS page
- ↑ Wilcoxon JS et al. (2007) Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Behav Brain Res 177: 109-16 PubMed GONUTS page
- ↑ Wikström L et al. (1998) Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J 17: 455-61 PubMed GONUTS page
- ↑ Mai W et al. (2004) Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A 101: 10332-7 PubMed GONUTS page
- ↑ 12.0 12.1 Dellovade TL et al. (2000) The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors. Nat Neurosci 3: 472-5 PubMed GONUTS page
- ↑ 13.0 13.1 Kendrick TS et al. (2008) Erythroid defects in TRalpha-/- mice. Blood 111: 3245-8 PubMed GONUTS page
- ↑ Flamant F et al. (2002) Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene. Mol Endocrinol 16: 24-32 PubMed GONUTS page
- ↑ 15.0 15.1 Malik S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 24: 8244-54 PubMed GONUTS page
- ↑ Eckey M et al. (2003) Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Mol Cell Endocrinol 213: 71-8 PubMed GONUTS page
- ↑ Weinberger C et al. (1986) The c-erb-A gene encodes a thyroid hormone receptor. Nature 324: 641-6 PubMed GONUTS page
