MGI:Th

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0001666	response to hypoxia	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	P	From MGI
	GO:0001666	response to hypoxia	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	P	From MGI
	GO:0001963	synaptic transmission, dopaminergic	MGI:MGI:2652924 PMID:12604788^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0001963	synaptic transmission, dopaminergic	MGI:MGI:3052583 PMID:15317940^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0004497	monooxygenase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0004511	tyrosine 3-monooxygenase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0004511	tyrosine 3-monooxygenase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	F	From MGI
	GO:0004511	tyrosine 3-monooxygenase activity	MGI:MGI:77787 PMID:7592982^[3]	TAS: Traceable Author Statement		F	From MGI
	GO:0005506	iron ion binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001273 InterPro:IPR018301	F	From MGI
	GO:0005634	nucleus	MGI:MGI:3531318 PMID:15643613^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1352916 PMID:10707987^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0005739	mitochondrion	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0005790	smooth endoplasmic reticulum	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0005829	cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0006585	dopamine biosynthetic process from tyrosine	MGI:MGI:1335713 PMID:10212311^[6]	TAS: Traceable Author Statement		P	From MGI
	GO:0006585	dopamine biosynthetic process from tyrosine	MGI:MGI:2386819 PMID:9520487^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006585	dopamine biosynthetic process from tyrosine	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	P	From MGI
	GO:0006585	dopamine biosynthetic process from tyrosine	MGI:MGI:72094 PMID:7715703^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860450	P	From MGI
	GO:0006585	dopamine biosynthetic process from tyrosine	MGI:MGI:77787 PMID:7592982^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860450	P	From MGI
	GO:0007507	heart development	MGI:MGI:1335713 PMID:10212311^[6]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860480	P	From MGI
	GO:0007507	heart development	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	P	From MGI
	GO:0007507	heart development	MGI:MGI:72094 PMID:7715703^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860450	P	From MGI
	GO:0007601	visual perception	MGI:MGI:3617102 PMID:16445854^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007612	learning	MGI:MGI:3027662 PMID:14684249^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0007613	memory	MGI:MGI:3027662 PMID:14684249^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0007617	mating behavior	MGI:MGI:1314754 PMID:9829800^[11]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0007626	locomotory behavior	MGI:MGI:2136522 PMID:11430814^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0007626	locomotory behavior	MGI:MGI:2450064 PMID:12538862^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:87934	P	From MGI
	GO:0007626	locomotory behavior	MGI:MGI:3027662 PMID:14684249^[10]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0008016	regulation of heart contraction	MGI:MGI:72094 PMID:7715703^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860450	P	From MGI
	GO:0008016	regulation of heart contraction	MGI:MGI:77787 PMID:7592982^[3]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860453	P	From MGI
	GO:0008021	synaptic vesicle	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0008198	ferrous iron binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0008199	ferric iron binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0009072	aromatic amino acid family metabolic process	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001273 InterPro:IPR018301	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:72094 PMID:7715703^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1860450	P	From MGI
	GO:0009898	internal side of plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0015842	synaptic vesicle amine transport	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	P	From MGI
	GO:0016491	oxidoreductase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0560	F	From MGI
	GO:0016597	amino acid binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR019774 InterPro:IPR019773	F	From MGI
	GO:0019717	synaptosome	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0019825	oxygen binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0030424	axon	MGI:MGI:3578029 PMID:15814794^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:3757895 PMID:17761882^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0030424	axon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0030425	dendrite	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0030659	cytoplasmic vesicle membrane	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0033162	melanosome membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0034617	tetrahydrobiopterin binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0035240	dopamine binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	F	From MGI
	GO:0042136	neurotransmitter biosynthetic process	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0530	P	From MGI
	GO:0042416	dopamine biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	P	From MGI
	GO:0042418	epinephrine biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	P	From MGI
	GO:0042421	norepinephrine biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	P	From MGI
	GO:0042423	catecholamine biosynthetic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	P	From MGI
	GO:0042462	eye photoreceptor cell development	MGI:MGI:3617102 PMID:16445854^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0042755	eating behavior	MGI:MGI:1855732 PMID:10802666^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:104663	P	From MGI
	GO:0042755	eating behavior	MGI:MGI:2136522 PMID:11430814^[12]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0042755	eating behavior	MGI:MGI:2450064 PMID:12538862^[13]	IGI: Inferred from Genetic Interaction	MGI:MGI:87934	P	From MGI
	GO:0042755	eating behavior	MGI:MGI:3054588 PMID:15374756^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1928960	P	From MGI
	GO:0043005	neuron projection	MGI:MGI:3604278 PMID:12074840^[18]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043005	neuron projection	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	C	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0043195	terminal button	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0043204	perikaryon	MGI:MGI:1339386 PMID:10350535^[19]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0043204	perikaryon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P04177	C	From MGI
	GO:0045471	response to ethanol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P07101	P	From MGI
	GO:0046872	metal ion binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0479	F	From MGI
	GO:0048596	embryonic camera-type eye morphogenesis	MGI:MGI:3617102 PMID:16445854^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Paladini CA et al. (2003) Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proc Natl Acad Sci U S A 100: 2866-71 PubMed GONUTS page
↑ Robinson S et al. (2004) Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia. Proc Natl Acad Sci U S A 101: 13329-34 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Kobayashi K et al. (1995) Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J Biol Chem 270: 27235-43 PubMed GONUTS page
↑ Jiang Z et al. (2005) Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat 25: 196-206 PubMed GONUTS page
↑ Abeliovich A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-52 PubMed GONUTS page
↑ ^6.0 ^6.1 Rios M et al. (1999) Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19: 3519-26 PubMed GONUTS page
↑ Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A 95: 4029-34 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Zhou QY et al. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374: 640-3 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Lavado A et al. (2006) Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin. J Neurochem 96: 1201-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Denenberg VH et al. (2004) The role of dopamine in learning, memory, and performance of a water escape task. Behav Brain Res 148: 73-8 PubMed GONUTS page
↑ Szczypka MS et al. (1998) Dopamine-stimulated sexual behavior is testosterone dependent in mice. Behav Neurosci 112: 1229-35 PubMed GONUTS page
↑ ^12.0 ^12.1 Szczypka MS et al. (2001) Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 30: 819-28 PubMed GONUTS page
↑ ^13.0 ^13.1 Kim DS & Palmiter RD (2003) Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice. Proc Natl Acad Sci U S A 100: 1346-51 PubMed GONUTS page
↑ Suto F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci 25: 3628-37 PubMed GONUTS page
↑ Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317: 1220-4 PubMed GONUTS page
↑ Szczypka MS et al. (2000) Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102-4 PubMed GONUTS page
↑ Hnasko TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res 1023: 309-18 PubMed GONUTS page
↑ Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
↑ Sawada K et al. (1999) Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice. Brain Res 829: 107-12 PubMed GONUTS page

[PMID:12604788-0] Paladini CA et al. (2003) Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Proc Natl Acad Sci U S A 100: 2866-71 PubMed GONUTS page

[PMID:15317940-1] Robinson S et al. (2004) Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia. Proc Natl Acad Sci U S A 101: 13329-34 PubMed GONUTS page

[PMID:7592982-2] 3.0 ^3.1 ^3.2 Kobayashi K et al. (1995) Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice. J Biol Chem 270: 27235-43 PubMed GONUTS page

[PMID:15643613-3] Jiang Z et al. (2005) Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus. Hum Mutat 25: 196-206 PubMed GONUTS page

[PMID:10707987-4] Abeliovich A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25: 239-52 PubMed GONUTS page

[PMID:10212311-5] 6.0 ^6.1 Rios M et al. (1999) Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19: 3519-26 PubMed GONUTS page

[PMID:9520487-6] Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A 95: 4029-34 PubMed GONUTS page

[PMID:7715703-7] 8.0 ^8.1 ^8.2 ^8.3 Zhou QY et al. (1995) Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature 374: 640-3 PubMed GONUTS page

[PMID:16445854-8] 9.0 ^9.1 ^9.2 Lavado A et al. (2006) Ectopic expression of tyrosine hydroxylase in the pigmented epithelium rescues the retinal abnormalities and visual function common in albinos in the absence of melanin. J Neurochem 96: 1201-11 PubMed GONUTS page

[PMID:14684249-9] 10.0 ^10.1 ^10.2 Denenberg VH et al. (2004) The role of dopamine in learning, memory, and performance of a water escape task. Behav Brain Res 148: 73-8 PubMed GONUTS page

[PMID:9829800-10] Szczypka MS et al. (1998) Dopamine-stimulated sexual behavior is testosterone dependent in mice. Behav Neurosci 112: 1229-35 PubMed GONUTS page

[PMID:11430814-11] 12.0 ^12.1 Szczypka MS et al. (2001) Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron 30: 819-28 PubMed GONUTS page

[PMID:12538862-12] 13.0 ^13.1 Kim DS & Palmiter RD (2003) Adenosine receptor blockade reverses hypophagia and enhances locomotor activity of dopamine-deficient mice. Proc Natl Acad Sci U S A 100: 1346-51 PubMed GONUTS page

[PMID:15814794-13] Suto F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci 25: 3628-37 PubMed GONUTS page

[PMID:17761882-14] Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317: 1220-4 PubMed GONUTS page

[PMID:10802666-15] Szczypka MS et al. (2000) Dopamine is required for hyperphagia in Lep(ob/ob) mice. Nat Genet 25: 102-4 PubMed GONUTS page

[PMID:15374756-16] Hnasko TS et al. (2004) A role for dopamine in feeding responses produced by orexigenic agents. Brain Res 1023: 309-18 PubMed GONUTS page

[PMID:12074840-17] Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page

[PMID:10350535-18] Sawada K et al. (1999) Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice. Brain Res 829: 107-12 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Th
Protein Name(s)	tyrosine hydroxylase,
External Links
MGI	MGI:98735

MGI:Th

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