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MGI:Tgfbr3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tgfbr3 ( synonyms: betaglycan, TBRIII ) | |
| Protein Name(s) | transforming growth factor, beta receptor III, | |
| External Links | ||
| MGI | MGI:104637 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001568 |
blood vessel development |
MGI:MGI:3818140 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3818438 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:3818140 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3818438 |
P |
From MGI |
||
| GO:0001824 |
blastocyst development |
MGI:MGI:1326851 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0001837 |
epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001889 |
liver development |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003347 |
epicardial cell to mesenchymal cell transition |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0004872 |
receptor activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0675 |
F |
From MGI |
||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:1271001 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:3762085 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0005024 |
transforming growth factor beta-activated receptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005114 |
type II transforming growth factor beta receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005160 |
transforming growth factor beta receptor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2663364 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005539 |
glycosaminoglycan binding |
MGI:MGI:2663364 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005576 |
extracellular region |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0964 |
C |
From MGI |
||
| GO:0005578 |
proteinaceous extracellular matrix |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005624 |
membrane fraction |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1326851 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3790191 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:1326851 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-1003 |
C |
From MGI |
||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005887 |
integral to plasma membrane |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0006461 |
protein complex assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0006955 |
immune response |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:3699491 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:3807767 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007179 |
transforming growth factor beta receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007181 |
transforming growth factor beta receptor complex assembly |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007243 |
intracellular protein kinase cascade |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008201 |
heparin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0009790 |
embryo development |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0009897 |
external side of plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3807767 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0010633 |
negative regulation of epithelial cell migration |
MGI:MGI:3762085 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010719 |
negative regulation of epithelial to mesenchymal transition |
MGI:MGI:3762085 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0015026 |
coreceptor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0472 |
C |
From MGI |
||
| GO:0016021 |
integral to membrane |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0016049 |
cell growth |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0017134 |
fibroblast growth factor binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030165 |
PDZ domain binding |
MGI:MGI:3807767 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030511 |
positive regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032354 |
response to follicle-stimulating hormone stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034673 |
inhibin-betaglycan-ActRII complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0034695 |
response to prostaglandin E stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0034699 |
response to luteinizing hormone stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043393 |
regulation of protein binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:3699491 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0046332 |
SMAD binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048185 |
activin binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:3699491 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050431 |
transforming growth factor beta binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0050680 |
negative regulation of epithelial cell proliferation |
MGI:MGI:3699491 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0050880 |
regulation of blood vessel size |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:3762085 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051271 |
negative regulation of cellular component movement |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060021 |
palate development |
MGI:MGI:3699491 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060038 |
cardiac muscle cell proliferation |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060216 |
definitive hemopoiesis |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060317 |
cardiac epithelial to mesenchymal transition |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060318 |
definitive erythrocyte differentiation |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060347 |
heart trabecula formation |
MGI:MGI:2663364 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
MGI:MGI:3699491 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060389 |
pathway-restricted SMAD protein phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060976 |
coronary vasculature development |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0060977 |
coronary vasculature morphogenesis |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0060979 |
vasculogenesis involved in coronary vascular morphogenesis |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0061032 |
visceral serous pericardium development |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0070123 |
transforming growth factor beta receptor activity, type III |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0070123 |
transforming growth factor beta receptor activity, type III |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Compton LA et al. (2007) Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res 101: 784-91 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Roelen BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64: 19-31 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol 23: 4371-85 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
- ↑ Ponce-Castañeda MV et al. (1998) Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites. Biochim Biophys Acta 1384: 189-96 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Criswell TL & Arteaga CL (2007) Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility. J Biol Chem 282: 32491-500 PubMed GONUTS page
- ↑ Sarraj MA et al. (2007) Differential expression of TGFBR3 (betaglycan) in mouse ovary and testis during gonadogenesis. Growth Factors 25: 334-45 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Nakajima A et al. (2007) Functional role of transforming growth factor-beta type III receptor during palatal fusion. Dev Dyn 236: 791-801 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Blobe GC et al. (2001) A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. J Biol Chem 276: 39608-17 PubMed GONUTS page
