MGI:Tgfb1

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000060	protein import into nucleus, translocation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3528807 PMID:15657445^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3584056 PMID:15990875^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:3036234 MGI:MGI:1333784 MGI:MGI:99829	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3584056 PMID:15990875^[2]	IGI: Inferred from Genetic Interaction	MGI:MGI:99829	P	From MGI
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:3797158 PMID:18212064^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:98834 MGI:MGI:106203	P	From MGI
	GO:0000165	MAPK cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0001501	skeletal system development	MGI:MGI:1334826 PMID:8421714^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0001501	skeletal system development	MGI:MGI:51412 PMID:1436033^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0001763	morphogenesis of a branching structure	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0001837	epithelial to mesenchymal transition	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0001933	negative regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0002028	regulation of sodium ion transport	MGI:MGI:3796353 PMID:16941024^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002062	chondrocyte differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0002244	hemopoietic progenitor cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	MGI:MGI:3851279 PMID:19501566^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0002513	tolerance induction to self antigen	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0005114	type II transforming growth factor beta receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	F	From MGI
	GO:0005160	transforming growth factor beta receptor binding	MGI:MGI:3766844 PMID:17878231^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q62312	F	From MGI
	GO:0005160	transforming growth factor beta receptor binding	MGI:MGI:3766844 PMID:17878231^[9]	IPI: Inferred from Physical Interaction	UniProtKB:Q64729	F	From MGI
	GO:0005160	transforming growth factor beta receptor binding	MGI:MGI:51412 PMID:1436033^[5]	TAS: Traceable Author Statement		F	From MGI
	GO:0005515	protein binding	MGI:MGI:2663364 PMID:12773577^[10]	IPI: Inferred from Physical Interaction	UniProtKB:O88393 UniProtKB:Q62312 UniProtKB:Q64729	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3034115 PMID:14985127^[11]	IPI: Inferred from Physical Interaction	UniProtKB:Q07475	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005578	proteinaceous extracellular matrix	MGI:MGI:2386340 PMID:12208849^[12]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005578	proteinaceous extracellular matrix	MGI:MGI:85085 PMID:9008713^[13]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:3836095 PMID:18753609^[14]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4820704 PMID:19734317^[15]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005615	extracellular space	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2386340 PMID:12208849^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:3761053 PMID:17898001^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:98958	P	From MGI
	GO:0006611	protein export from nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0006754	ATP biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0006796	phosphate-containing compound metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0006874	cellular calcium ion homeostasis	MGI:MGI:3641518 PMID:12646629^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0006952	defense response	MGI:MGI:1334826 PMID:8421714^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:1334826 PMID:8421714^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857671	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0006954	inflammatory response	MGI:MGI:51412 PMID:1436033^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0007173	epidermal growth factor receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:2386340 PMID:12208849^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007179	transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0007183	SMAD protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0007184	SMAD protein import into nucleus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0007184	SMAD protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0007406	negative regulation of neuroblast proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0007492	endoderm development	MGI:MGI:1326851 PMID:9921650^[18]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007519	skeletal muscle tissue development	MGI:MGI:51412 PMID:1436033^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0008083	growth factor activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0339	F	From MGI
	GO:0008083	growth factor activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001839 InterPro:IPR001111 InterPro:IPR017948	F	From MGI
	GO:0008156	negative regulation of DNA replication	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0008219	cell death	MGI:MGI:1334826 PMID:8421714^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857671	P	From MGI
	GO:0008219	cell death	MGI:MGI:51412 PMID:1436033^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:1334826 PMID:8421714^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:2386340 PMID:12208849^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008283	cell proliferation	MGI:MGI:51412 PMID:1436033^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:3525900 PMID:15604101^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0008284	positive regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:1334826 PMID:8421714^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0008354	germ cell migration	MGI:MGI:3588906 PMID:15993878^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0009817	defense response to fungus, incompatible interaction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0009887	organ morphogenesis	MGI:MGI:1334826 PMID:8421714^[4]	TAS: Traceable Author Statement		P	From MGI
	GO:0009986	cell surface	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0010033	response to organic substance	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:3709446 PMID:17293613^[21]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010628	positive regulation of gene expression	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0010718	positive regulation of epithelial to mesenchymal transition	MGI:MGI:3821807 PMID:18794329^[22]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0010718	positive regulation of epithelial to mesenchymal transition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0010763	positive regulation of fibroblast migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0010936	negative regulation of macrophage cytokine production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0016049	cell growth	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR003939	P	From MGI
	GO:0016202	regulation of striated muscle tissue development	MGI:MGI:2153314 PMID:11711431^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0019049	evasion of host defenses by virus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0019899	enzyme binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	F	From MGI
	GO:0022408	negative regulation of cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0030141	secretory granule	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0030214	hyaluronan catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0030217	T cell differentiation	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0030279	negative regulation of ossification	MGI:MGI:3575204 PMID:15820682^[24]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:2663364 PMID:12773577^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0030308	negative regulation of cell growth	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0030335	positive regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0030424	axon	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0030879	mammary gland development	MGI:MGI:50512 PMID:1821856^[25]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031012	extracellular matrix	MGI:MGI:80427 PMID:2209468^[26]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0031065	positive regulation of histone deacetylation	MGI:MGI:3528807 PMID:15657445^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031065	positive regulation of histone deacetylation	MGI:MGI:3584056 PMID:15990875^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0031100	organ regeneration	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0031334	positive regulation of protein complex assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0031536	positive regulation of exit from mitosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0031575	mitotic cell cycle G1/S transition checkpoint	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0031663	lipopolysaccharide-mediated signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032270	positive regulation of cellular protein metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032355	response to estradiol stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032570	response to progesterone stimulus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:3851279 PMID:19501566^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032740	positive regulation of interleukin-17 production	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032801	receptor catabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0032943	mononuclear cell proliferation	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4820704 PMID:19734317^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032967	positive regulation of collagen biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0035066	positive regulation of histone acetylation	MGI:MGI:3584056 PMID:15990875^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035307	positive regulation of protein dephosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0040007	growth	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR001111	P	From MGI
	GO:0042060	wound healing	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0042110	T cell activation	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0042110	T cell activation	MGI:MGI:3823129 PMID:18997793^[27]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042127	regulation of cell proliferation	MGI:MGI:2176657 PMID:11799106^[28]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042130	negative regulation of T cell proliferation	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0042306	regulation of protein import into nucleus	MGI:MGI:2176657 PMID:11799106^[28]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042307	positive regulation of protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0042482	positive regulation of odontogenesis	MGI:MGI:69105 PMID:7848824^[29]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0042552	myelination	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0042803	protein homodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	F	From MGI
	GO:0043011	myeloid dendritic cell differentiation	MGI:MGI:3760597 PMID:17938236^[30]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0043025	neuronal cell body	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	C	From MGI
	GO:0043029	T cell homeostasis	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3719583	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0043406	positive regulation of MAP kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0043491	protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0043499	eukaryotic cell surface binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	F	From MGI
	GO:0043536	positive regulation of blood vessel endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0043537	negative regulation of blood vessel endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045066	regulatory T cell differentiation	MGI:MGI:3041050 PMID:15100250^[31]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045066	regulatory T cell differentiation	MGI:MGI:3718815 PMID:17481928^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:3576270 MGI:MGI:3719583	P	From MGI
	GO:0045216	cell-cell junction organization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045662	negative regulation of myoblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045786	negative regulation of cell cycle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3041050 PMID:15100250^[31]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3513643 PMID:15282343^[32]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045930	negative regulation of mitotic cell cycle	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3584056 PMID:15990875^[2]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3716271 PMID:17568773^[33]	IGI: Inferred from Genetic Interaction	MGI:MGI:1347465 MGI:MGI:108051 MGI:MGI:894293	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3763776 PMID:17951031^[34]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3823129 PMID:18997793^[27]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0046982	protein heterodimerization activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	F	From MGI
	GO:0047485	protein N-terminus binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	F	From MGI
	GO:0048298	positive regulation of isotype switching to IgA isotypes	MGI:MGI:3037416 PMID:14988498^[35]	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0048535	lymph node development	MGI:MGI:51412 PMID:1436033^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0048642	negative regulation of skeletal muscle tissue development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0050680	negative regulation of epithelial cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0050714	positive regulation of protein secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0050765	negative regulation of phagocytosis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0050777	negative regulation of immune response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0050868	negative regulation of T cell activation	MGI:MGI:3641518 PMID:12646629^[17]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0050921	positive regulation of chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0051092	positive regulation of NF-kappaB transcription factor activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0051098	regulation of binding	MGI:MGI:3513643 PMID:15282343^[32]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051101	regulation of DNA binding	MGI:MGI:3513643 PMID:15282343^[32]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0051152	positive regulation of smooth muscle cell differentiation	MGI:MGI:81256 PMID:8616889^[36]	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0051781	positive regulation of cell division	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0497	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0060389	pathway-restricted SMAD protein phosphorylation	MGI:MGI:2663364 PMID:12773577^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0060389	pathway-restricted SMAD protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0060391	positive regulation of SMAD protein import into nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0060744	mammary gland branching involved in thelarche	MGI:MGI:3814777 PMID:18614704^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0060751	branch elongation involved in mammary gland duct branching	MGI:MGI:3814777 PMID:18614704^[37]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857258	P	From MGI
	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	MGI:MGI:3761053 PMID:17898001^[16]	IGI: Inferred from Genetic Interaction	MGI:MGI:98958	P	From MGI
	GO:0061035	regulation of cartilage development	MGI:MGI:4830625 PMID:20501701^[38]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070306	lens fiber cell differentiation	MGI:MGI:3720408 PMID:17215516^[39]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070723	response to cholesterol	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0071158	positive regulation of cell cycle arrest	MGI:MGI:3820325 PMID:19056892^[40]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071363	cellular response to growth factor stimulus	MGI:MGI:69105 PMID:7848824^[29]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0071407	cellular response to organic cyclic compound	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0071549	cellular response to dexamethasone stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:0085029	extracellular matrix assembly	MGI:MGI:4820704 PMID:19734317^[15]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0085029	extracellular matrix assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:P17246	P	From MGI
	GO:1900126	negative regulation of hyaluronan biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P01137	P	From MGI
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Wilkinson DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25: 1200-12 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kang JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J 24: 2543-55 PubMed GONUTS page
↑ Wilkinson DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol 28: 1988-98 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kulkarni AB et al. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 90: 770-4 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Shull MM et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-9 PubMed GONUTS page
↑ Wakida N et al. (2006) Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int 70: 1432-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Morishima N et al. (2009) TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem Biophys Res Commun 386: 105-10 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Li MO et al. (2007) T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26: 579-91 PubMed GONUTS page
↑ ^9.0 ^9.1 Chen CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci 120: 3509-21 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol 23: 4371-85 PubMed GONUTS page
↑ Paliwal S et al. (2004) P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem Biophys Res Commun 315: 1104-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Sterner-Kock A et al. (2002) Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 16: 2264-73 PubMed GONUTS page
↑ Nakajima Y et al. (1997) Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol 136: 193-204 PubMed GONUTS page
↑ Wu JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod 79: 1054-61 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Salazar KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297: L1002-11 PubMed GONUTS page
↑ ^16.0 ^16.1 Roarty K & Serra R (2007) Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development 134: 3929-39 PubMed GONUTS page
↑ ^17.0 ^17.1 Bommireddy R et al. (2003) TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol 170: 3645-52 PubMed GONUTS page
↑ Roelen BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64: 19-31 PubMed GONUTS page
↑ Kettunen P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132: 323-34 PubMed GONUTS page
↑ Chuva de Sousa Lopes SM et al. (2005) Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5. Dev Biol 284: 194-203 PubMed GONUTS page
↑ Ghosh M et al. (2007) Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem 282: 11676-86 PubMed GONUTS page
↑ Hirano M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol 182: 1217-30 PubMed GONUTS page
↑ Liu D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 15: 2950-66 PubMed GONUTS page
↑ Yamashita M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121: 101-13 PubMed GONUTS page
↑ Robinson SD et al. (1991) Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development 113: 867-78 PubMed GONUTS page
↑ Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109: 29-36 PubMed GONUTS page
↑ ^27.0 ^27.1 Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9: 1347-55 PubMed GONUTS page
↑ ^28.0 ^28.1 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page
↑ ^29.0 ^29.1 Bègue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol 38: 405-20 PubMed GONUTS page
↑ Kaplan DH et al. (2007) Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 204: 2545-52 PubMed GONUTS page
↑ ^31.0 ^31.1 Fantini MC et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-53 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 Subramanian SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell 15: 4532-43 PubMed GONUTS page
↑ Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J 26: 3132-43 PubMed GONUTS page
↑ Kettunen P et al. (2007) Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev 124: 868-83 PubMed GONUTS page
↑ Castigli E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A 101: 3903-8 PubMed GONUTS page
↑ Shah NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85: 331-43 PubMed GONUTS page
↑ ^37.0 ^37.1 Ingman WV & Robertson SA (2008) Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79: 711-7 PubMed GONUTS page
↑ Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci 123: 2068-76 PubMed GONUTS page
↑ Wu G et al. (2007) The anaphase-promoting complex coordinates initiation of lens differentiation. Mol Biol Cell 18: 1018-29 PubMed GONUTS page
↑ Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

[PMID:15657445-0] 1.0 ^1.1 Wilkinson DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25: 1200-12 PubMed GONUTS page

[PMID:15990875-1] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Kang JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J 24: 2543-55 PubMed GONUTS page

[PMID:18212064-2] Wilkinson DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol 28: 1988-98 PubMed GONUTS page

[PMID:8421714-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Kulkarni AB et al. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 90: 770-4 PubMed GONUTS page

[PMID:1436033-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Shull MM et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359: 693-9 PubMed GONUTS page

[PMID:16941024-5] Wakida N et al. (2006) Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int 70: 1432-8 PubMed GONUTS page

[PMID:19501566-6] 7.0 ^7.1 Morishima N et al. (2009) TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem Biophys Res Commun 386: 105-10 PubMed GONUTS page

[PMID:17481928-7] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Li MO et al. (2007) T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity 26: 579-91 PubMed GONUTS page

[PMID:17878231-8] 9.0 ^9.1 Chen CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci 120: 3509-21 PubMed GONUTS page

[PMID:12773577-9] 10.0 ^10.1 ^10.2 Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol 23: 4371-85 PubMed GONUTS page

[PMID:14985127-10] Paliwal S et al. (2004) P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem Biophys Res Commun 315: 1104-9 PubMed GONUTS page

[PMID:12208849-11] 12.0 ^12.1 ^12.2 ^12.3 Sterner-Kock A et al. (2002) Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 16: 2264-73 PubMed GONUTS page

[PMID:9008713-12] Nakajima Y et al. (1997) Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol 136: 193-204 PubMed GONUTS page

[PMID:18753609-13] Wu JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod 79: 1054-61 PubMed GONUTS page

[PMID:19734317-14] 15.0 ^15.1 ^15.2 Salazar KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 297: L1002-11 PubMed GONUTS page

[PMID:17898001-15] 16.0 ^16.1 Roarty K & Serra R (2007) Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth. Development 134: 3929-39 PubMed GONUTS page

[PMID:12646629-16] 17.0 ^17.1 Bommireddy R et al. (2003) TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol 170: 3645-52 PubMed GONUTS page

[PMID:9921650-17] Roelen BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64: 19-31 PubMed GONUTS page

[PMID:15604101-18] Kettunen P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132: 323-34 PubMed GONUTS page

[PMID:15993878-19] Chuva de Sousa Lopes SM et al. (2005) Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5. Dev Biol 284: 194-203 PubMed GONUTS page

[PMID:17293613-20] Ghosh M et al. (2007) Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem 282: 11676-86 PubMed GONUTS page

[PMID:18794329-21] Hirano M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol 182: 1217-30 PubMed GONUTS page

[PMID:11711431-22] Liu D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 15: 2950-66 PubMed GONUTS page

[PMID:15820682-23] Yamashita M et al. (2005) Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation. Cell 121: 101-13 PubMed GONUTS page

[PMID:1821856-24] Robinson SD et al. (1991) Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development 113: 867-78 PubMed GONUTS page

[PMID:2209468-25] Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development 109: 29-36 PubMed GONUTS page

[PMID:18997793-26] 27.0 ^27.1 Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol 9: 1347-55 PubMed GONUTS page

[PMID:11799106-27] 28.0 ^28.1 Chang NS (2002) The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. J Biol Chem 277: 10323-31 PubMed GONUTS page

[PMID:7848824-28] 29.0 ^29.1 Bègue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol 38: 405-20 PubMed GONUTS page

[PMID:17938236-29] Kaplan DH et al. (2007) Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 204: 2545-52 PubMed GONUTS page

[PMID:15100250-30] 31.0 ^31.1 Fantini MC et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 172: 5149-53 PubMed GONUTS page

[PMID:15282343-31] 32.0 ^32.1 ^32.2 Subramanian SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell 15: 4532-43 PubMed GONUTS page

[PMID:17568773-32] Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J 26: 3132-43 PubMed GONUTS page

[PMID:17951031-33] Kettunen P et al. (2007) Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev 124: 868-83 PubMed GONUTS page

[PMID:14988498-34] Castigli E et al. (2004) Impaired IgA class switching in APRIL-deficient mice. Proc Natl Acad Sci U S A 101: 3903-8 PubMed GONUTS page

[PMID:8616889-35] Shah NM et al. (1996) Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell 85: 331-43 PubMed GONUTS page

[PMID:18614704-36] 37.0 ^37.1 Ingman WV & Robertson SA (2008) Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79: 711-7 PubMed GONUTS page

[PMID:20501701-37] Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci 123: 2068-76 PubMed GONUTS page

[PMID:17215516-38] Wu G et al. (2007) The anaphase-promoting complex coordinates initiation of lens differentiation. Mol Biol Cell 18: 1018-29 PubMed GONUTS page

[PMID:19056892-39] Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev 22: 3121-34 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Tgfb1 ( synonyms: TGF-beta 1, TGF-beta1, Tgfb, Tgfb-1, TGFbeta1 )
Protein Name(s)	transforming growth factor, beta 1,
External Links
MGI	MGI:98725

MGI:Tgfb1

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