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MGI:Tff2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tff2 ( synonyms: mSP, SP ) | |
| Protein Name(s) | trefoil factor 2 (spasmolytic protein 1), | |
| External Links | ||
| MGI | MGI:1306805 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005615 |
extracellular space |
MGI:MGI:3841526 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4450959 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:3841526 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:2158108 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179101 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3841526 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0019722 |
calcium-mediated signaling |
MGI:MGI:3841526 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:3841526 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103556 |
P |
From MGI |
||
| GO:0031723 |
CXCR4 chemokine receptor binding |
MGI:MGI:3841526 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043031 |
negative regulation of macrophage activation |
MGI:MGI:3694595 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179101 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3694595 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179101 |
P |
From MGI |
||
| GO:0050728 |
negative regulation of inflammatory response |
MGI:MGI:3763484 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179101 |
P |
From MGI |
||
| GO:0060455 |
negative regulation of gastric acid secretion |
MGI:MGI:2158108 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179101 |
P |
From MGI |
||
| GO:0070098 |
chemokine-mediated signaling pathway |
MGI:MGI:3841526 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:103556 |
P |
From MGI |
||
| GO:0070374 |
positive regulation of ERK1 and ERK2 cascade |
MGI:MGI:3841526 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Dubeykovskaya Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem 284: 3650-62 PubMed GONUTS page
- ↑ Menheniott TR et al. (2010) A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of adaptive gene loss in humans. Gastroenterology 138: 1823-35 PubMed GONUTS page
- ↑ 3.0 3.1 Farrell JJ et al. (2002) TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. J Clin Invest 109: 193-204 PubMed GONUTS page
- ↑ 4.0 4.1 Kurt-Jones EA et al. (2007) Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun 75: 471-80 PubMed GONUTS page
- ↑ Fox JG et al. (2007) Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171: 1520-8 PubMed GONUTS page
