GONUTS is under stress! The website is currently experiencing long-wait times and frequent time-outs due to the record number of students, groups, and annotations related to CACAO this semester. We are currently working on increasing performance -- please accept our apologies for the technical difficulties.
You can help reduce stress on the server by:
- not reloading pages frequently - this just adds
- opening links in new windows (so you can read the old page)
MGI:Terf2ip
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Terf2ip ( synonyms: Rap1 ) | |
| Protein Name(s) | telomeric repeat binding factor 2, interacting protein, | |
| External Links | ||
| MGI | MGI:1929871 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000723 |
telomere maintenance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000781 |
chromosome, telomeric region |
MGI:MGI:4440768 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000781 |
chromosome, telomeric region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000781 |
chromosome, telomeric region |
MGI:MGI:4839412 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0000783 |
nuclear telomere cap complex |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000784 |
nuclear chromosome, telomeric region |
MGI:MGI:3615734 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000784 |
nuclear chromosome, telomeric region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4440768 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4821187 |
IPI: Inferred from Physical Interaction |
UniProtKB:O35144 |
F |
From MGI |
||
| GO:0005634 |
nucleus |
MGI:MGI:4821187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4821187 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:4839412 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010569 |
regulation of double-strand break repair via homologous recombination |
MGI:MGI:4440768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010833 |
telomere maintenance via telomere lengthening |
MGI:MGI:4440768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0010833 |
telomere maintenance via telomere lengthening |
MGI:MGI:4839412 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0031848 |
protection from non-homologous end joining at telomere |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0032205 |
negative regulation of telomere maintenance |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043123 |
positive regulation of I-kappaB kinase/NF-kappaB cascade |
MGI:MGI:4821187 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048239 |
negative regulation of DNA recombination at telomere |
MGI:MGI:4440768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048239 |
negative regulation of DNA recombination at telomere |
MGI:MGI:4839412 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
MGI:MGI:4821187 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0070198 |
protein localization to chromosome, telomeric region |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0031848 |
protection from non-homologous end joining at telomere |
MGI:MGI:4440768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
||
|
NOT |
GO:0031848 |
protection from non-homologous end joining at telomere |
MGI:MGI:4839412 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Sfeir A et al. (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327: 1657-61 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Martinez P et al. (2010) Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat Cell Biol 12: 768-80 PubMed GONUTS page
- ↑ Celli GB & de Lange T (2005) DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol 7: 712-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Teo H et al. (2010) Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol 12: 758-67 PubMed GONUTS page
