MGI:Tek

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1315113 PMID:9846489^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159357	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:4943617 PMID:20299672^[2]	TAS: Traceable Author Statement		P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:74274 PMID:7596437^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001569	patterning of blood vessels	MGI:MGI:4943617 PMID:20299672^[2]	TAS: Traceable Author Statement		P	From MGI
	GO:0001570	vasculogenesis	MGI:MGI:68132 PMID:7958865^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001934	positive regulation of protein phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0001935	endothelial cell proliferation	MGI:MGI:68132 PMID:7958865^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0001936	regulation of endothelial cell proliferation	MGI:MGI:4830635 PMID:20406889^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0002040	sprouting angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:68132 PMID:7958865^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	F	From MGI
	GO:0004714	transmembrane receptor protein tyrosine kinase activity	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	F	From MGI
	GO:0004872	receptor activity	MGI:MGI:84853 PMID:8980223^[6]	IPI: Inferred from Physical Interaction	UniProtKB:O08538	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4412467 PMID:10557082^[7]	IPI: Inferred from Physical Interaction	UniProtKB:B2RU80	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0067	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR017441 InterPro:IPR018941	F	From MGI
	GO:0005576	extracellular region	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0964	C	From MGI
	GO:0005622	intracellular	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099207	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From MGI
	GO:0005856	cytoskeleton	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0206	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1003	C	From MGI
	GO:0005887	integral to plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0005902	microvillus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0005911	cell-cell junction	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR018941 InterPro:IPR008266 InterPro:IPR020635	P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:3848848 PMID:19409199^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:108448	P	From MGI
	GO:0007160	cell-matrix adhesion	MGI:MGI:2387759 PMID:9683559^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152096	IEA: Inferred from Electronic Annotation	EC:2.7.10.1	P	From MGI
	GO:0007165	signal transduction	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR018941	P	From MGI
	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0007507	heart development	MGI:MGI:68132 PMID:7958865^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0009925	basal plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0009986	cell surface	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4830635 PMID:20406889^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0010595	positive regulation of endothelial cell migration	MGI:MGI:4943617 PMID:20299672^[2]	TAS: Traceable Author Statement		P	From MGI
	GO:0010740	positive regulation of intracellular protein kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0014068	positive regulation of phosphatidylinositol 3-kinase cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016021	integral to membrane	MGI:MGI:63311 PMID:8415706^[10]	ISM: Inferred from Sequence Model		C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016323	basolateral plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0016324	apical plasma membrane	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0016337	cell-cell adhesion	MGI:MGI:2387759 PMID:9683559^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P	From MGI
	GO:0016525	negative regulation of angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:68132 PMID:7958865^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019838	growth factor binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099207	F	From MGI
	GO:0030054	cell junction	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0965	C	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:1315113 PMID:9846489^[1]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159357	P	From MGI
	GO:0030097	hemopoiesis	MGI:MGI:3051189 PMID:15260986^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030334	regulation of cell migration	MGI:MGI:2387759 PMID:9683559^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P	From MGI
	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	MGI:MGI:4830635 PMID:20406889^[5]	TAS: Traceable Author Statement		P	From MGI
	GO:0032526	response to retinoic acid	MGI:MGI:3799604 PMID:18439490^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0032878	regulation of establishment or maintenance of cell polarity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0033138	positive regulation of peptidyl-serine phosphorylation	MGI:MGI:3848848 PMID:19409199^[8]	IGI: Inferred from Genetic Interaction	MGI:MGI:108448	P	From MGI
	GO:0034446	substrate adhesion-dependent cell spreading	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099207	P	From MGI
	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0043627	response to estrogen stimulus	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099207	P	From MGI
	GO:0045121	membrane raft	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	C	From MGI
	GO:0045765	regulation of angiogenesis	MGI:MGI:2387759 PMID:9683559^[9]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2159358	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	NCBI:NP_001099207	P	From MGI
	GO:0045766	positive regulation of angiogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0045785	positive regulation of cell adhesion	MGI:MGI:3051189 PMID:15260986^[11]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0048014	Tie receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0048014	Tie receptor signaling pathway	MGI:MGI:4943617 PMID:20299672^[2]	TAS: Traceable Author Statement		P	From MGI
	GO:0051259	protein oligomerization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0051894	positive regulation of focal adhesion assembly	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:0060347	heart trabecula formation	MGI:MGI:68132 PMID:7958865^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:2000251	positive regulation of actin cytoskeleton reorganization	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q02763	P	From MGI
	GO:2000352	negative regulation of endothelial cell apoptotic process	MGI:MGI:3691072 PMID:11375937^[13]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Takakura N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9: 677-86 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
↑ Sato TN et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376: 70-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dumont DJ et al. (1994) Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 8: 1897-909 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page
↑ Davis S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87: 1161-9 PubMed GONUTS page
↑ Fachinger G et al. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18: 5948-53 PubMed GONUTS page
↑ ^8.0 ^8.1 Bai Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160: 371-81 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Patan S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res 56: 1-21 PubMed GONUTS page
↑ Sato TN et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A 90: 9355-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Arai F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-61 PubMed GONUTS page
↑ Su D & Gudas LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol 36: 624-41 PubMed GONUTS page
↑ Jones N et al. (2001) Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep 2: 438-45 PubMed GONUTS page

[PMID:9846489-0] 1.0 ^1.1 Takakura N et al. (1998) Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9: 677-86 PubMed GONUTS page

[PMID:20299672-1] 2.0 ^2.1 ^2.2 ^2.3 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page

[PMID:7596437-2] Sato TN et al. (1995) Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376: 70-4 PubMed GONUTS page

[PMID:7958865-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Dumont DJ et al. (1994) Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev 8: 1897-909 PubMed GONUTS page

[PMID:20406889-4] 5.0 ^5.1 ^5.2 Suzuki Y et al. (2010) BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci 123: 1684-92 PubMed GONUTS page

[PMID:8980223-5] Davis S et al. (1996) Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell 87: 1161-9 PubMed GONUTS page

[PMID:10557082-6] Fachinger G et al. (1999) Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene 18: 5948-53 PubMed GONUTS page

[PMID:19409199-7] 8.0 ^8.1 Bai Y et al. (2009) An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160: 371-81 PubMed GONUTS page

[PMID:9683559-8] 9.0 ^9.1 ^9.2 ^9.3 Patan S (1998) TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Microvasc Res 56: 1-21 PubMed GONUTS page

[PMID:8415706-9] Sato TN et al. (1993) Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. Proc Natl Acad Sci U S A 90: 9355-8 PubMed GONUTS page

[PMID:15260986-10] 11.0 ^11.1 Arai F et al. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118: 149-61 PubMed GONUTS page

[PMID:18439490-11] Su D & Gudas LJ (2008) Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol 36: 624-41 PubMed GONUTS page

[PMID:11375937-12] Jones N et al. (2001) Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function. EMBO Rep 2: 438-45 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Tek ( synonyms: Cd202b, Hyk, tie-2, Tie2 )
Protein Name(s)	endothelial-specific receptor tyrosine kinase,
External Links
MGI	MGI:98664

MGI:Tek

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