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MGI:Tdgf1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tdgf1 ( synonyms: CR1, cripto ) | |
| Protein Name(s) | teratocarcinoma-derived growth factor 1, | |
| External Links | ||
| MGI | MGI:98658 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000187 |
activation of MAPK activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000187 |
activation of MAPK activity |
MGI:MGI:86062 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001570 |
vasculogenesis |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0001701 |
in utero embryonic development |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0001954 |
positive regulation of cell-matrix adhesion |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0002042 |
cell migration involved in sprouting angiogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0005102 |
receptor binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3611720 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3771280 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:1353202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:74600 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3799386 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:74600 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:74600 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007369 |
gastrulation |
MGI:MGI:3776330 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201414 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008083 |
growth factor activity |
MGI:MGI:67068 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:67068 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0008595 |
anterior/posterior axis specification, embryo |
MGI:MGI:1303194 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1934206 |
P |
From MGI |
||
| GO:0009948 |
anterior/posterior axis specification |
MGI:MGI:3776330 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1201414 |
P |
From MGI |
||
| GO:0009966 |
regulation of signal transduction |
MGI:MGI:3763867 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0009966 |
regulation of signal transduction |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:3771280 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010595 |
positive regulation of endothelial cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016324 |
apical plasma membrane |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0018105 |
peptidyl-serine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0019897 |
extrinsic to plasma membrane |
MGI:MGI:1353202 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019897 |
extrinsic to plasma membrane |
MGI:MGI:2179650 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030334 |
regulation of cell migration |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0030335 |
positive regulation of cell migration |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3703823 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030512 |
negative regulation of transforming growth factor beta receptor signaling pathway |
MGI:MGI:3771280 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95835 |
P |
From MGI |
||
| GO:0035729 |
cellular response to hepatocyte growth factor stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0044344 |
cellular response to fibroblast growth factor stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045121 |
membrane raft |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3716271 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1347465 |
P |
From MGI |
||
| GO:0048146 |
positive regulation of fibroblast proliferation |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0048471 |
perinuclear region of cytoplasm |
MGI:MGI:74600 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0055007 |
cardiac muscle cell differentiation |
MGI:MGI:1321047 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857518 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3703823 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0071346 |
cellular response to interferon-gamma |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071354 |
cellular response to interleukin-6 |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071356 |
cellular response to tumor necrosis factor |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0071364 |
cellular response to epidermal growth factor stimulus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
|
NOT |
GO:0007173 |
epidermal growth factor receptor signaling pathway |
MGI:MGI:67068 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kannan S et al. (1997) Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem 272: 3330-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Xu C et al. (1999) Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development 126: 483-94 PubMed GONUTS page
- ↑ Chen C et al. (2006) The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development 133: 319-29 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Shani G et al. (2008) GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol 28: 666-77 PubMed GONUTS page
- ↑ 5.0 5.1 Minchiotti G et al. (2000) Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Mech Dev 90: 133-42 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Kenney NJ et al. (1995) Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. Mol Reprod Dev 41: 277-86 PubMed GONUTS page
- ↑ Strizzi L et al. (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol 216: 824-34 PubMed GONUTS page
- ↑ 8.0 8.1 Liguori GL et al. (2008) Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol 315: 280-9 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Brandt R et al. (1994) Identification and biological characterization of an epidermal growth factor-related protein: cripto-1. J Biol Chem 269: 17320-8 PubMed GONUTS page
- ↑ Ding J et al. (1998) Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature 395: 702-7 PubMed GONUTS page
- ↑ Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol 311: 500-11 PubMed GONUTS page
- ↑ Minchiotti G et al. (2002) Role of the EGF-CFC gene cripto in cell differentiation and embryo development. Gene 287: 33-7 PubMed GONUTS page
- ↑ 13.0 13.1 Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A 104: 3859-64 PubMed GONUTS page
- ↑ Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J 26: 3132-43 PubMed GONUTS page
