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MGI:Tcfap2c
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tcfap2c ( synonyms: Ap-2.2, AP2gamma, Stra2 ) | |
| Protein Name(s) | transcription factor AP-2, gamma, | |
| External Links | ||
| MGI | MGI:106032 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
MGI:MGI:1336374 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:62661 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001077 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001078 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001829 |
trophectodermal cell differentiation |
MGI:MGI:4819480 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040993 |
P |
From MGI |
||
| GO:0001942 |
hair follicle development |
MGI:MGI:3826689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104671 |
P |
From MGI |
||
| GO:0003334 |
keratinocyte development |
MGI:MGI:3826689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104671 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:2182583 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2182583 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3054669 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2179743 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:2679158 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:2182583 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3826689 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2182583 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3054669 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021877 |
forebrain neuron fate commitment |
MGI:MGI:4397655 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176695 |
P |
From MGI |
||
| GO:0021987 |
cerebral cortex development |
MGI:MGI:4397655 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176695 |
P |
From MGI |
||
| GO:0030154 |
cell differentiation |
MGI:MGI:2386497 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040993 |
P |
From MGI |
||
| GO:0030718 |
germ-line stem cell maintenance |
MGI:MGI:4421115 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2176695 |
P |
From MGI |
||
| GO:0035019 |
somatic stem cell maintenance |
MGI:MGI:4819480 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040993 |
P |
From MGI |
||
| GO:0043588 |
skin development |
MGI:MGI:3826689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104671 |
P |
From MGI |
||
| GO:0045682 |
regulation of epidermis development |
MGI:MGI:3795061 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2182570 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1336374 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:2179743 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4397655 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:62661 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0046983 |
protein dimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0048733 |
sebaceous gland development |
MGI:MGI:3826689 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104671 |
P |
From MGI |
||
| GO:0060598 |
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis |
MGI:MGI:4422106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040993 |
P |
From MGI |
||
| GO:0060750 |
epithelial cell proliferation involved in mammary gland duct elongation |
MGI:MGI:4422106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3040993 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Maconochie M et al. (1999) Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family. Development 126: 1483-94 PubMed GONUTS page
- ↑ 2.0 2.1 Lim LC et al. (1993) Characterization of the molecularly cloned murine alpha-globin transcription factor CP2. J Biol Chem 268: 18008-17 PubMed GONUTS page
- ↑ 3.0 3.1 Kuckenberg P et al. (2010) The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Mol Cell Biol 30: 3310-20 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Wang X et al. (2008) AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. J Cell Biol 183: 37-48 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Shi D & Kellems RE (1998) Transcription factor AP-2gamma regulates murine adenosine deaminase gene expression during placental development. J Biol Chem 273: 27331-8 PubMed GONUTS page
- ↑ 6.0 6.1 Bamforth SD et al. (2004) Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet 36: 1189-96 PubMed GONUTS page
- ↑ 7.0 7.1 Bamforth SD et al. (2001) Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator. Nat Genet 29: 469-74 PubMed GONUTS page
- ↑ Feng W & Williams T (2003) Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci 24: 460-75 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Pinto L et al. (2009) AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Nat Neurosci 12: 1229-37 PubMed GONUTS page
- ↑ Werling U & Schorle H (2002) Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol 22: 3149-56 PubMed GONUTS page
- ↑ Weber S et al. (2010) Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Biol Reprod 82: 214-23 PubMed GONUTS page
- ↑ Guttormsen J et al. (2008) Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice. Dev Biol 317: 187-95 PubMed GONUTS page
- ↑ 13.0 13.1 Jäger R et al. (2010) Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Dev Dyn 239: 1027-33 PubMed GONUTS page
