MGI:Tcf7l2

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0001568	blood vessel development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0238	F	From MGI
	GO:0003682	chromatin binding	MGI:MGI:3763856 PMID:17727834^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4459044		PANTHER:PTHR10373	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3688344 PMID:15102471^[2]	IPI: Inferred from Physical Interaction	UniProtKB:P39428	F	From MGI
	GO:0005515	protein binding	MGI:MGI:4359141 PMID:19503085^[3]	IPI: Inferred from Physical Interaction	UniProtKB:O09106 UniProtKB:P70288	F	From MGI
	GO:0005515	protein binding	MGI:MGI:5009785 PMID:20044351^[4]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F	From MGI
	GO:0005634	nucleus	MGI:MGI:1276271 PMID:9697701^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3799610 PMID:15578569^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4412144 PMID:19718027^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5009785 PMID:20044351^[4]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005654	nucleoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:2668307 PMID:12861022^[8]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005829	cytosol	MGI:MGI:3799610 PMID:15578569^[6]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:2668307 PMID:12861022^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:4459044		PANTHER:PTHR10373	P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0006357	regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0006916	anti-apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0007050	cell cycle arrest	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:1196720 PMID:9488439^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:1313068 PMID:9784592^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:2677113 PMID:12874278^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q02248	F	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:4359141 PMID:19503085^[3]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0008013	beta-catenin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0008283	cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0009749	response to glucose stimulus	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0010909	positive regulation of heparan sulfate proteoglycan biosynthetic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0014003	oligodendrocyte development	MGI:MGI:4360127 PMID:19741146^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:1196720 PMID:9488439^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0016055	Wnt receptor signaling pathway	MGI:MGI:3722225 PMID:17699607^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96770	P	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0021915	neural tube development	MGI:MGI:3042541 PMID:15057272^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98507	P	From MGI
	GO:0021983	pituitary gland development	MGI:MGI:3763872 PMID:17919533^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0030282	bone mineralization	MGI:MGI:3850932 PMID:19213727^[17]	IGI: Inferred from Genetic Interaction	MGI:MGI:101948	P	From MGI
	GO:0030514	negative regulation of BMP signaling pathway	MGI:MGI:3763872 PMID:17919533^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0030538	embryonic genitalia morphogenesis	MGI:MGI:3042541 PMID:15057272^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98507	P	From MGI
	GO:0031641	regulation of myelination	MGI:MGI:4359141 PMID:19503085^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032024	positive regulation of insulin secretion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0032092	positive regulation of protein binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0032252	secretory granule localization	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0032350	regulation of hormone metabolic process	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0032993	protein-DNA complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	C	From MGI
	GO:0035019	somatic stem cell maintenance	MGI:MGI:1276271 PMID:9697701^[5]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0035019	somatic stem cell maintenance	MGI:MGI:1330442 PMID:10027409^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0035019	somatic stem cell maintenance	MGI:MGI:3841508 PMID:19251639^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0035019	somatic stem cell maintenance	MGI:MGI:4412144 PMID:19718027^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:1202876	P	From MGI
	GO:0035257	nuclear hormone receptor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0035411	catenin import into nucleus	MGI:MGI:1306742 PMID:9792805^[20]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	MGI:MGI:3763872 PMID:17919533^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0042475	odontogenesis of dentin-containing tooth	MGI:MGI:3722225 PMID:17699607^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96770	P	From MGI
	GO:0042593	glucose homeostasis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0043065	positive regulation of apoptotic process	MGI:MGI:3763872 PMID:17919533^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4459044		PANTHER:PTHR10373	F	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0043570	maintenance of DNA repeat elements	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0043588	skin development	MGI:MGI:4412144 PMID:19718027^[7]	IGI: Inferred from Genetic Interaction	MGI:MGI:1202876	P	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4459044		PANTHER:PTHR10373	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0044212	transcription regulatory region DNA binding	MGI:MGI:5009785 PMID:20044351^[4]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0044334	canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0045295	gamma-catenin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0045444	fat cell differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0045599	negative regulation of fat cell differentiation	MGI:MGI:3758508 PMID:10937998^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045892	negative regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3579620 PMID:15778706^[22]	IGI: Inferred from Genetic Interaction	MGI:MGI:88276	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4947862 PMID:21335239^[23]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:5009785 PMID:20044351^[4]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046621	negative regulation of organ growth	MGI:MGI:3763872 PMID:17919533^[16]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0046827	positive regulation of protein export from nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0048557	embryonic digestive tract morphogenesis	MGI:MGI:3042541 PMID:15057272^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98507	P	From MGI
	GO:0048619	embryonic hindgut morphogenesis	MGI:MGI:3042541 PMID:15057272^[15]	IGI: Inferred from Genetic Interaction	MGI:MGI:98507	P	From MGI
	GO:0048625	myoblast cell fate commitment	MGI:MGI:3758508 PMID:10937998^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0048625	myoblast cell fate commitment	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0048641	regulation of skeletal muscle tissue development	MGI:MGI:4879035 PMID:21177349^[24]	IMP: Inferred from Mutant Phenotype	MGI:MGI:4881345	P	From MGI
	GO:0048660	regulation of smooth muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0048713	regulation of oligodendrocyte differentiation	MGI:MGI:4359141 PMID:19503085^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050679	positive regulation of epithelial cell proliferation	MGI:MGI:3841508 PMID:19251639^[19]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1926344	P	From MGI
	GO:0051897	positive regulation of protein kinase B signaling cascade	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
	GO:0060070	canonical Wnt receptor signaling pathway	MGI:MGI:3758508 PMID:10937998^[21]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0060325	face morphogenesis	MGI:MGI:3722225 PMID:17699607^[14]	IGI: Inferred from Genetic Interaction	MGI:MGI:96770	P	From MGI
	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:D4A9H4	P	From MGI
	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	MGI:MGI:4412432 PMID:19168596^[9]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0070016	armadillo repeat domain binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	F	From MGI
	GO:0070369	beta-catenin-TCF7L2 complex	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	C	From MGI
	GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q9NQB0	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Miller KA et al. (2007) A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells. Dev Biol 311: 665-78 PubMed GONUTS page
↑ Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Ye F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 12: 829-38 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Weise A et al. (2010) Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res 38: 1964-81 PubMed GONUTS page
↑ ^5.0 ^5.1 Korinek V et al. (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19: 379-83 PubMed GONUTS page
↑ ^6.0 ^6.1 Kanda S et al. (2005) T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells. J Cell Biochem 94: 835-47 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Nguyen H et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41: 1068-75 PubMed GONUTS page
↑ ^8.0 ^8.1 Kennell JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol 23: 5366-75 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 da Silva Xavier G et al. (2009) TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes 58: 894-905 PubMed GONUTS page
↑ ^10.0 ^10.1 Korinek V et al. (1998) Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol 18: 1248-56 PubMed GONUTS page
↑ Cho EA & Dressler GR (1998) TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs. Mech Dev 77: 9-18 PubMed GONUTS page
↑ Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem 278: 38758-64 PubMed GONUTS page
↑ Fu H et al. (2009) A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci 29: 11399-408 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Brugmann SA et al. (2007) Wnt signaling mediates regional specification in the vertebrate face. Development 134: 3283-95 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Gregorieff A et al. (2004) Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J 23: 1825-33 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Brinkmeier ML et al. (2007) TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol 311: 396-407 PubMed GONUTS page
↑ Friedman MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem 284: 14117-25 PubMed GONUTS page
↑ Wielenga VJ et al. (1999) Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154: 515-23 PubMed GONUTS page
↑ ^19.0 ^19.1 Fre S et al. (2009) Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A 106: 6309-14 PubMed GONUTS page
↑ Ogawa S et al. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. Biochem Biophys Res Commun 251: 515-9 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page
↑ van Es JH et al. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 7: 381-6 PubMed GONUTS page
↑ Fujiwara H et al. (2011) The basement membrane of hair follicle stem cells is a muscle cell niche. Cell 144: 577-89 PubMed GONUTS page
↑ Mathew SJ et al. (2011) Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development 138: 371-84 PubMed GONUTS page

[PMID:17727834-0] Miller KA et al. (2007) A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells. Dev Biol 311: 665-78 PubMed GONUTS page

[PMID:15102471-1] Papin J & Subramaniam S (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol 15: 78-81 PubMed GONUTS page

[PMID:19503085-2] 3.0 ^3.1 ^3.2 ^3.3 Ye F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci 12: 829-38 PubMed GONUTS page

[PMID:20044351-3] 4.0 ^4.1 ^4.2 ^4.3 Weise A et al. (2010) Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets. Nucleic Acids Res 38: 1964-81 PubMed GONUTS page

[PMID:9697701-4] 5.0 ^5.1 Korinek V et al. (1998) Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat Genet 19: 379-83 PubMed GONUTS page

[PMID:15578569-5] 6.0 ^6.1 Kanda S et al. (2005) T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells. J Cell Biochem 94: 835-47 PubMed GONUTS page

[PMID:19718027-6] 7.0 ^7.1 ^7.2 Nguyen H et al. (2009) Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia. Nat Genet 41: 1068-75 PubMed GONUTS page

[PMID:12861022-7] 8.0 ^8.1 Kennell JA et al. (2003) T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors. Mol Cell Biol 23: 5366-75 PubMed GONUTS page

[PMID:19168596-8] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 da Silva Xavier G et al. (2009) TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes 58: 894-905 PubMed GONUTS page

[PMID:9488439-9] 10.0 ^10.1 Korinek V et al. (1998) Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol 18: 1248-56 PubMed GONUTS page

[PMID:9784592-10] Cho EA & Dressler GR (1998) TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs. Mech Dev 77: 9-18 PubMed GONUTS page

[PMID:12874278-11] Kanamori M et al. (2003) The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells. J Biol Chem 278: 38758-64 PubMed GONUTS page

[PMID:19741146-12] Fu H et al. (2009) A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci 29: 11399-408 PubMed GONUTS page

[PMID:17699607-13] 14.0 ^14.1 ^14.2 Brugmann SA et al. (2007) Wnt signaling mediates regional specification in the vertebrate face. Development 134: 3283-95 PubMed GONUTS page

[PMID:15057272-14] 15.0 ^15.1 ^15.2 ^15.3 Gregorieff A et al. (2004) Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J 23: 1825-33 PubMed GONUTS page

[PMID:17919533-15] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Brinkmeier ML et al. (2007) TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors. Dev Biol 311: 396-407 PubMed GONUTS page

[PMID:19213727-16] Friedman MS et al. (2009) Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem 284: 14117-25 PubMed GONUTS page

[PMID:10027409-17] Wielenga VJ et al. (1999) Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol 154: 515-23 PubMed GONUTS page

[PMID:19251639-18] 19.0 ^19.1 Fre S et al. (2009) Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A 106: 6309-14 PubMed GONUTS page

[PMID:9792805-19] Ogawa S et al. (1998) Molecular cloning of a novel RING finger-B box-coiled coil (RBCC) protein, terf, expressed in the testis. Biochem Biophys Res Commun 251: 515-9 PubMed GONUTS page

[PMID:10937998-20] 21.0 ^21.1 ^21.2 Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-3 PubMed GONUTS page

[PMID:15778706-21] van Es JH et al. (2005) Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol 7: 381-6 PubMed GONUTS page

[PMID:21335239-22] Fujiwara H et al. (2011) The basement membrane of hair follicle stem cells is a muscle cell niche. Cell 144: 577-89 PubMed GONUTS page

[PMID:21177349-23] Mathew SJ et al. (2011) Connective tissue fibroblasts and Tcf4 regulate myogenesis. Development 138: 371-84 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Tcf7l2 ( synonyms: mTcf-4B, mTcf-4E, Tcf-4, Tcf4, TCF4B, TCF4E )
Protein Name(s)	transcription factor 7 like 2, T cell specific, HMG box,
External Links
MGI	MGI:1202879

MGI:Tcf7l2

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