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MGI:Tcf7
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tcf7 ( synonyms: T cell factor-1, T-cell factor 1, TCF-1, Tcf1 ) | |
| Protein Name(s) | transcription factor 7, T cell specific, | |
| External Links | ||
| MGI | MGI:98507 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:59589 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834989 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:59589 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005667 |
transcription factor complex |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0007420 |
brain development |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0016055 |
Wnt receptor signaling pathway |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021915 |
neural tube development |
MGI:MGI:3042541 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0022008 |
neurogenesis |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0030538 |
embryonic genitalia morphogenesis |
MGI:MGI:3042541 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0033153 |
T cell receptor V(D)J recombination |
MGI:MGI:3640275 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96770 |
P |
From MGI |
||
| GO:0042127 |
regulation of cell proliferation |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0042981 |
regulation of apoptotic process |
MGI:MGI:2386811 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
F |
From MGI |
|||
| GO:0044212 |
transcription regulatory region DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0046632 |
alpha-beta T cell differentiation |
MGI:MGI:3640275 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96770 |
P |
From MGI |
||
| GO:0048557 |
embryonic digestive tract morphogenesis |
MGI:MGI:3042541 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0048619 |
embryonic hindgut morphogenesis |
MGI:MGI:3042541 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1202879 |
P |
From MGI |
||
| GO:0048699 |
generation of neurons |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:4459044 |
PANTHER:PTHR10373 |
P |
From MGI |
|||
| GO:0071353 |
cellular response to interleukin-4 |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Widlund HR et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 158: 1079-87 PubMed GONUTS page
- ↑ 2.0 2.1 Oosterwegel M et al. (1991) Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers. J Exp Med 173: 1133-42 PubMed GONUTS page
- ↑ Hebenstreit D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J Biol Chem 283: 22490-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gregorieff A et al. (2004) Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J 23: 1825-33 PubMed GONUTS page
- ↑ 5.0 5.1 Okamura RM et al. (1998) Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8: 11-20 PubMed GONUTS page
