MGI:Tbx5

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	MGI:MGI:5284807 PMID:14550786^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0002009	morphogenesis of an epithelium	MGI:MGI:2448119 PMID:12508227^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003166	bundle of His development	MGI:MGI:3716040 PMID:17604724^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:97350	P	From MGI
	GO:0003181	atrioventricular valve morphogenesis	MGI:MGI:3833786 PMID:19084512^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0003197	endocardial cushion development	MGI:MGI:3833786 PMID:19084512^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0003218	cardiac left ventricle formation	MGI:MGI:4356350 PMID:19727199^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003229	ventricular cardiac muscle tissue development	MGI:MGI:3833786 PMID:19084512^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
	GO:0003281	ventricular septum development	MGI:MGI:4356350 PMID:19727199^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0003283	atrial septum development	MGI:MGI:3833786 PMID:19084512^[4]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0003677	DNA binding	MGI:MGI:2150846 PMID:11555635^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2150876 PMID:11572777^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:2448173 PMID:12490567^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:3040553 PMID:14978031^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003677	DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2150846 PMID:11555635^[6]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2150876 PMID:11572777^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:2448173 PMID:12490567^[8]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:3040553 PMID:14978031^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0003700	sequence-specific DNA binding transcription factor activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	F	From MGI
	GO:0005515	protein binding	MGI:MGI:2150876 PMID:11572777^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P42582	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3614736 PMID:16380715^[10]	IPI: Inferred from Physical Interaction	UniProtKB:Q8BX22	F	From MGI
	GO:0005634	nucleus	MGI:MGI:2150876 PMID:11572777^[7]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:3639368 PMID:16684884^[11]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005634	nucleus	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	C	From MGI
	GO:0005634	nucleus	MGI:MGI:5284807 PMID:14550786^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0005667	transcription factor complex	MGI:MGI:4461870 PMID:18285513^[12]	IPI: Inferred from Physical Interaction	UniProtKB:Q9ERF6 UniProtKB:Q03358	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	C	From MGI
	GO:0006351	transcription, DNA-dependent	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0804	P	From MGI
	GO:0006355	regulation of transcription, DNA-dependent	MGI:MGI:3663956 PMID:16870172^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0006917	induction of apoptosis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0007267	cell-cell signaling	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0007275	multicellular organismal development	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0217	P	From MGI
	GO:0007389	pattern specification process	MGI:MGI:3051695 PMID:15289437^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0007507	heart development	MGI:MGI:2150876 PMID:11572777^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0007507	heart development	MGI:MGI:3051695 PMID:15289437^[14]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0007507	heart development	MGI:MGI:3663956 PMID:16870172^[13]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0007507	heart development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0007507	heart development	MGI:MGI:84816 PMID:8988164^[15]	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0007507	heart development	MGI:MGI:84817 PMID:8988165^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0008134	transcription factor binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	F	From MGI
	GO:0008285	negative regulation of cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0030324	lung development	MGI:MGI:2448119 PMID:12508227^[2]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030326	embryonic limb morphogenesis	MGI:MGI:2660722 PMID:12736217^[17]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0030326	embryonic limb morphogenesis	MGI:MGI:3614736 PMID:16380715^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:2139360	P	From MGI
	GO:0030326	embryonic limb morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0030336	negative regulation of cell migration	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0035115	embryonic forelimb morphogenesis	MGI:MGI:2150876 PMID:11572777^[7]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0035115	embryonic forelimb morphogenesis	MGI:MGI:2448173 PMID:12490567^[8]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387851	P	From MGI
	GO:0035117	embryonic arm morphogenesis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0035136	forelimb morphogenesis	MGI:MGI:3527352 PMID:15621531^[18]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2387850	P	From MGI
	GO:0035136	forelimb morphogenesis	MGI:MGI:84816 PMID:8988164^[15]	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0035136	forelimb morphogenesis	MGI:MGI:84817 PMID:8988165^[16]	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0043565	sequence-specific DNA binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	F	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2150846 PMID:11555635^[6]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2150876 PMID:11572777^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:2448173 PMID:12490567^[8]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3040553 PMID:14978031^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:3604925 PMID:15843409^[19]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3614736 PMID:16380715^[10]	IGI: Inferred from Genetic Interaction	MGI:MGI:2139360	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:3716040 PMID:17604724^[3]	IGI: Inferred from Genetic Interaction	MGI:MGI:97350	P	From MGI
	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0051891	positive regulation of cardioblast differentiation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0055007	cardiac muscle cell differentiation	MGI:MGI:3833825 PMID:11431700^[20]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0055007	cardiac muscle cell differentiation	MGI:MGI:4881377 PMID:20691899^[21]	IGI: Inferred from Genetic Interaction	MGI:MGI:99458 MGI:MGI:95664	P	From MGI
	GO:0060039	pericardium development	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0060044	negative regulation of cardiac muscle cell proliferation	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:Q99593	P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:3833786 PMID:19084512^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:107516	P	From MGI
	GO:0060045	positive regulation of cardiac muscle cell proliferation	MGI:MGI:3833786 PMID:19084512^[4]	IGI: Inferred from Genetic Interaction	MGI:MGI:95664	P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Stennard FA et al. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 262: 206-24 PubMed GONUTS page
↑ ^2.0 ^2.1 Cebra-Thomas JA et al. (2003) T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn 226: 82-90 PubMed GONUTS page
↑ ^3.0 ^3.1 Moskowitz IP et al. (2007) A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 129: 1365-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol 326: 368-77 PubMed GONUTS page
↑ ^5.0 ^5.1 Koshiba-Takeuchi K et al. (2009) Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature 461: 95-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Ghosh TK et al. (2001) Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome. Hum Mol Genet 10: 1983-94 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Bruneau BG et al. (2001) A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-21 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Agarwal P et al. (2003) Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development 130: 623-33 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Plageman TF Jr & Yutzey KE (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J Biol Chem 279: 19026-34 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Koshiba-Takeuchi K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet 38: 175-83 PubMed GONUTS page
↑ Paylor R et al. (2006) Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A 103: 7729-34 PubMed GONUTS page
↑ Boogerd KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res 78: 485-93 PubMed GONUTS page
↑ ^13.0 ^13.1 Mori AD et al. (2006) Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol 297: 566-86 PubMed GONUTS page
↑ ^14.0 ^14.1 Moskowitz IP et al. (2004) The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131: 4107-16 PubMed GONUTS page
↑ ^15.0 ^15.1 Li QY et al. (1997) Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet 15: 21-9 PubMed GONUTS page
↑ ^16.0 ^16.1 Basson CT et al. (1997) Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet 15: 30-5 PubMed GONUTS page
↑ Rallis C et al. (2003) Tbx5 is required for forelimb bud formation and continued outgrowth. Development 130: 2741-51 PubMed GONUTS page
↑ Minguillon C et al. (2005) Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev Cell 8: 75-84 PubMed GONUTS page
↑ Takeuchi JK et al. (2005) Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-74 PubMed GONUTS page
↑ Hiroi Y et al. (2001) Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28: 276-80 PubMed GONUTS page
↑ Ieda M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-86 PubMed GONUTS page

[PMID:14550786-0] 1.0 ^1.1 Stennard FA et al. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 262: 206-24 PubMed GONUTS page

[PMID:12508227-1] 2.0 ^2.1 Cebra-Thomas JA et al. (2003) T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn 226: 82-90 PubMed GONUTS page

[PMID:17604724-2] 3.0 ^3.1 Moskowitz IP et al. (2007) A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 129: 1365-76 PubMed GONUTS page

[PMID:19084512-3] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Maitra M et al. (2009) Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol 326: 368-77 PubMed GONUTS page

[PMID:19727199-4] 5.0 ^5.1 Koshiba-Takeuchi K et al. (2009) Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature 461: 95-8 PubMed GONUTS page

[PMID:11555635-5] 6.0 ^6.1 ^6.2 Ghosh TK et al. (2001) Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome. Hum Mol Genet 10: 1983-94 PubMed GONUTS page

[PMID:11572777-6] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Bruneau BG et al. (2001) A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-21 PubMed GONUTS page

[PMID:12490567-7] 8.0 ^8.1 ^8.2 ^8.3 Agarwal P et al. (2003) Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo. Development 130: 623-33 PubMed GONUTS page

[PMID:14978031-8] 9.0 ^9.1 ^9.2 Plageman TF Jr & Yutzey KE (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J Biol Chem 279: 19026-34 PubMed GONUTS page

[PMID:16380715-9] 10.0 ^10.1 ^10.2 Koshiba-Takeuchi K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat Genet 38: 175-83 PubMed GONUTS page

[PMID:16684884-10] Paylor R et al. (2006) Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A 103: 7729-34 PubMed GONUTS page

[PMID:18285513-11] Boogerd KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res 78: 485-93 PubMed GONUTS page

[PMID:16870172-12] 13.0 ^13.1 Mori AD et al. (2006) Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol 297: 566-86 PubMed GONUTS page

[PMID:15289437-13] 14.0 ^14.1 Moskowitz IP et al. (2004) The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131: 4107-16 PubMed GONUTS page

[PMID:8988164-14] 15.0 ^15.1 Li QY et al. (1997) Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet 15: 21-9 PubMed GONUTS page

[PMID:8988165-15] 16.0 ^16.1 Basson CT et al. (1997) Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet 15: 30-5 PubMed GONUTS page

[PMID:12736217-16] Rallis C et al. (2003) Tbx5 is required for forelimb bud formation and continued outgrowth. Development 130: 2741-51 PubMed GONUTS page

[PMID:15621531-17] Minguillon C et al. (2005) Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Dev Cell 8: 75-84 PubMed GONUTS page

[PMID:15843409-18] Takeuchi JK et al. (2005) Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-74 PubMed GONUTS page

[PMID:11431700-19] Hiroi Y et al. (2001) Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28: 276-80 PubMed GONUTS page

[PMID:20691899-20] Ieda M et al. (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142: 375-86 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Tbx5
Protein Name(s)	T-box 5,
External Links
MGI	MGI:102541

MGI:Tbx5

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