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MGI:Tbx20
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tbx20 ( synonyms: Tbx12 ) | |
| Protein Name(s) | T-box 20, | |
| External Links | ||
| MGI | MGI:1888496 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4943647 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:894293 |
P |
From MGI |
||
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000977 |
RNA polymerase II regulatory region sequence-specific DNA binding |
MGI:MGI:5284807 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001085 |
RNA polymerase II transcription factor binding |
MGI:MGI:5284807 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001102 |
RNA polymerase II activating transcription factor binding |
MGI:MGI:5284807 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0001105 |
RNA polymerase II transcription coactivator activity |
MGI:MGI:5284807 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:3578574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579836 |
P |
From MGI |
||
| GO:0001764 |
neuron migration |
MGI:MGI:3703101 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2386545 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:3578601 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579849 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:3579960 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3580099 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003148 |
outflow tract septum morphogenesis |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003148 |
outflow tract septum morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003175 |
tricuspid valve development |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003176 |
aortic valve development |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003180 |
aortic valve morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003193 |
pulmonary valve formation |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003207 |
cardiac chamber formation |
MGI:MGI:4943647 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3580099 |
P |
From MGI |
||
| GO:0003215 |
cardiac right ventricle morphogenesis |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003272 |
endocardial cushion formation |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003279 |
cardiac septum development |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3040553 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:3578601 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:1928541 |
TAS: Traceable Author Statement |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3040553 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:3578601 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3604925 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:5284807 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:5284807 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006936 |
muscle contraction |
MGI:MGI:3578574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579836 |
P |
From MGI |
||
| GO:0008015 |
blood circulation |
MGI:MGI:3578574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579836 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:3578601 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579849 |
P |
From MGI |
||
| GO:0009953 |
dorsal/ventral pattern formation |
MGI:MGI:3579960 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3580099 |
P |
From MGI |
||
| GO:0010717 |
regulation of epithelial to mesenchymal transition |
MGI:MGI:3604925 |
NAS: Non-traceable Author Statement |
P |
From MGI |
|||
| GO:0010991 |
negative regulation of SMAD protein complex assembly |
MGI:MGI:4943647 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0021524 |
visceral motor neuron differentiation |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035050 |
embryonic heart tube development |
MGI:MGI:3578574 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97350 |
P |
From MGI |
||
| GO:0035050 |
embryonic heart tube development |
MGI:MGI:3578574 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3579836 |
P |
From MGI |
||
| GO:0035922 |
foramen ovale closure |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3040553 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3578601 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3578601 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3604925 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:5284807 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0055008 |
cardiac muscle tissue morphogenesis |
MGI:MGI:3604925 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060413 |
atrial septum morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060577 |
pulmonary vein morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Singh R et al. (2009) Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal. Circ Res 105: 442-52 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Stennard FA et al. (2003) Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 262: 206-24 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Stennard FA et al. (2005) Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132: 2451-62 PubMed GONUTS page
- ↑ Song MR et al. (2006) T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration. Development 133: 4945-55 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Cai CL et al. (2005) T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132: 2475-87 PubMed GONUTS page
- ↑ 6.0 6.1 Singh MK et al. (2005) Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development 132: 2697-707 PubMed GONUTS page
- ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 Takeuchi JK et al. (2005) Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-74 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Plageman TF Jr & Yutzey KE (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J Biol Chem 279: 19026-34 PubMed GONUTS page
- ↑ Kraus F et al. (2001) Cloning and expression analysis of the mouse T-box gene tbx20. Mech Dev 100: 87-91 PubMed GONUTS page
