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MGI:Tbx1
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Tbx1 | |
| Protein Name(s) | T-box 1, | |
| External Links | ||
| MGI | MGI:98493 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001525 |
angiogenesis |
MGI:MGI:2178739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0001568 |
blood vessel development |
MGI:MGI:1930542 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0001568 |
blood vessel development |
MGI:MGI:3608154 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001568 |
blood vessel development |
MGI:MGI:3614586 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104686 |
P |
From MGI |
||
| GO:0001569 |
patterning of blood vessels |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0001708 |
cell fate specification |
MGI:MGI:3039048 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0001708 |
cell fate specification |
MGI:MGI:3044254 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1351209 |
P |
From MGI |
||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:3530686 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0001755 |
neural crest cell migration |
MGI:MGI:4822099 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0001934 |
positive regulation of protein phosphorylation |
MGI:MGI:5285152 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001945 |
lymph vessel development |
MGI:MGI:4452526 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046793 |
P |
From MGI |
||
| GO:0001974 |
blood vessel remodeling |
MGI:MGI:3690261 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99604 |
P |
From MGI |
||
| GO:0002053 |
positive regulation of mesenchymal cell proliferation |
MGI:MGI:5284768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3045669 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046792 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3050165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3640736 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046795 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:3656355 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0003148 |
outflow tract septum morphogenesis |
MGI:MGI:5285152 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:3770747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3664784 |
P |
From MGI |
||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:4353596 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0003151 |
outflow tract morphogenesis |
MGI:MGI:5002778 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109344 |
P |
From MGI |
||
| GO:0003677 |
DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4819465 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4848250 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4879036 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3697808 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3809316 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4848250 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109340 |
P |
From MGI |
||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3621085 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:3512717 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:3530686 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0007389 |
pattern specification process |
MGI:MGI:3614586 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104686 |
P |
From MGI |
||
| GO:0007498 |
mesoderm development |
MGI:MGI:2138050 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:1931408 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:2138050 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:2178739 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3614586 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104686 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3621085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109340 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:3621085 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0007507 |
heart development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007507 |
heart development |
MGI:MGI:4879036 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0007517 |
muscle organ development |
MGI:MGI:3512717 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:3050165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0007605 |
sensory perception of sound |
MGI:MGI:3629255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932522 |
P |
From MGI |
||
| GO:0008283 |
cell proliferation |
MGI:MGI:3656355 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3763333 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046793 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3039048 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3614586 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:104686 |
P |
From MGI |
||
| GO:0021644 |
vagus nerve morphogenesis |
MGI:MGI:4948210 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:3848106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0030855 |
epithelial cell differentiation |
MGI:MGI:4848250 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0030878 |
thyroid gland development |
MGI:MGI:3050165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0030878 |
thyroid gland development |
MGI:MGI:3697808 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0030878 |
thyroid gland development |
MGI:MGI:3848569 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99604 |
P |
From MGI |
||
| GO:0030878 |
thyroid gland development |
MGI:MGI:3848569 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0035176 |
social behavior |
MGI:MGI:3639368 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0035909 |
aorta morphogenesis |
MGI:MGI:3770747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3664784 |
P |
From MGI |
||
| GO:0035909 |
aorta morphogenesis |
MGI:MGI:5002778 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109344 |
P |
From MGI |
||
| GO:0042471 |
ear morphogenesis |
MGI:MGI:3050165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:2671642 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3039048 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3530686 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0042472 |
inner ear morphogenesis |
MGI:MGI:3629255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3619149 |
P |
From MGI |
||
| GO:0042473 |
outer ear morphogenesis |
MGI:MGI:3629255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932522 |
P |
From MGI |
||
| GO:0042474 |
middle ear morphogenesis |
MGI:MGI:3530686 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0042474 |
middle ear morphogenesis |
MGI:MGI:3629255 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1932522 |
P |
From MGI |
||
| GO:0042474 |
middle ear morphogenesis |
MGI:MGI:4822099 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:3848106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0042475 |
odontogenesis of dentin-containing tooth |
MGI:MGI:4848250 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0042693 |
muscle cell fate commitment |
MGI:MGI:3809316 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0042803 |
protein homodimerization activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043410 |
positive regulation of MAPK cascade |
MGI:MGI:5285152 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043587 |
tongue morphogenesis |
MGI:MGI:3809313 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0044344 |
cellular response to fibroblast growth factor stimulus |
MGI:MGI:5285152 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:4943633 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3045669 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3577119 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3604925 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:3639368 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045893 |
positive regulation of transcription, DNA-dependent |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3621085 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97350 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4819465 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1344416 |
P |
From MGI |
||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4879036 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0048384 |
retinoic acid receptor signaling pathway |
MGI:MGI:3809313 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048514 |
blood vessel morphogenesis |
MGI:MGI:1931408 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0048538 |
thymus development |
MGI:MGI:3770747 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3664784 |
P |
From MGI |
||
| GO:0048538 |
thymus development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048644 |
muscle organ morphogenesis |
MGI:MGI:3849775 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:97252 |
P |
From MGI |
||
| GO:0048701 |
embryonic cranial skeleton morphogenesis |
MGI:MGI:3050165 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0048703 |
embryonic viscerocranium morphogenesis |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0048703 |
embryonic viscerocranium morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0048752 |
semicircular canal morphogenesis |
MGI:MGI:4397600 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2444748 |
P |
From MGI |
||
| GO:0048844 |
artery morphogenesis |
MGI:MGI:2138050 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0048844 |
artery morphogenesis |
MGI:MGI:4358009 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95668 |
P |
From MGI |
||
| GO:0048844 |
artery morphogenesis |
MGI:MGI:4397600 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:2444748 |
P |
From MGI |
||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:3703494 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046793 |
P |
From MGI |
||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:3765363 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:3848106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:4848250 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0050679 |
positive regulation of epithelial cell proliferation |
MGI:MGI:5284768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060017 |
parathyroid gland development |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0060017 |
parathyroid gland development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060023 |
soft palate development |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0060023 |
soft palate development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:1095819 |
ISS: Inferred from Sequence or Structural Similarity |
P |
From MGI |
|||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:3763333 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046793 |
P |
From MGI |
||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:4879036 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060037 |
pharyngeal system development |
MGI:MGI:5002778 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:109344 |
P |
From MGI |
||
| GO:0060325 |
face morphogenesis |
MGI:MGI:4822099 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:0060415 |
muscle tissue morphogenesis |
MGI:MGI:3849775 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0060982 |
coronary artery morphogenesis |
MGI:MGI:4353596 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179190 |
P |
From MGI |
||
| GO:0060982 |
coronary artery morphogenesis |
MGI:MGI:4943617 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0070166 |
enamel mineralization |
MGI:MGI:3848106 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0071600 |
otic vesicle morphogenesis |
MGI:MGI:3703494 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3046793 |
P |
From MGI |
||
| GO:0072513 |
positive regulation of secondary heart field cardioblast proliferation |
MGI:MGI:4943633 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:3765363 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:0090103 |
cochlea morphogenesis |
MGI:MGI:5284768 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0097152 |
mesenchymal cell apoptotic process |
MGI:MGI:5284768 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2000027 |
regulation of organ morphogenesis |
MGI:MGI:3697808 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179191 |
P |
From MGI |
||
| GO:2000027 |
regulation of organ morphogenesis |
MGI:MGI:3848569 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:99604 |
P |
From MGI |
||
| GO:2000027 |
regulation of organ morphogenesis |
MGI:MGI:3848569 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179136 |
P |
From MGI |
||
| GO:2001037 |
positive regulation of tongue muscle cell differentiation |
MGI:MGI:3809313 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:2001054 |
negative regulation of mesenchymal cell apoptotic process |
MGI:MGI:5284768 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Vitelli F et al. (2002) Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet 11: 915-22 PubMed GONUTS page
- ↑ Lindsay EA et al. (2001) Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature 410: 97-101 PubMed GONUTS page
- ↑ Zhang Z et al. (2005) Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development 132: 5307-15 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Guris DL et al. (2006) Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev Cell 10: 81-92 PubMed GONUTS page
- ↑ 5.0 5.1 Olivey HE & Svensson EC (2010) Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res 106: 818-32 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Raft S et al. (2004) Suppression of neural fate and control of inner ear morphogenesis by Tbx1. Development 131: 1801-12 PubMed GONUTS page
- ↑ Cheng L et al. (2004) Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates. Nat Neurosci 7: 510-7 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 Moraes F et al. (2005) Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Mech Dev 122: 199-212 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 Aggarwal VS et al. (2010) Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol 344: 669-81 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 10.3 Vitelli F et al. (2010) Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol 49: 836-40 PubMed GONUTS page
- ↑ Chen L et al. (2010) Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol 189: 417-24 PubMed GONUTS page
- ↑ Aggarwal VS et al. (2006) Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet 15: 3219-28 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 13.3 13.4 Braunstein EM et al. (2008) Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol 9: 33-43 PubMed GONUTS page
- ↑ 14.0 14.1 Xu H et al. (2004) Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 131: 3217-27 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 Liao J et al. (2004) Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Hum Mol Genet 13: 1577-85 PubMed GONUTS page
- ↑ Vitelli F et al. (2006) Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol 295: 559-70 PubMed GONUTS page
- ↑ 17.0 17.1 Zhang Z et al. (2006) Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development 133: 3587-95 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 Zhang Z & Baldini A (2008) In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet 17: 150-7 PubMed GONUTS page
- ↑ 19.0 19.1 Théveniau-Ruissy M et al. (2008) The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning. Circ Res 103: 142-8 PubMed GONUTS page
- ↑ 20.0 20.1 20.2 Guo C et al. (2011) A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest 121: 1585-95 PubMed GONUTS page
- ↑ 21.0 21.1 Stoller JZ et al. (2010) Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood) 235: 569-76 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 22.3 22.4 Cao H et al. (2010) Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol 347: 289-300 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Okubo T et al. (2011) Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development 138: 339-48 PubMed GONUTS page
- ↑ 24.0 24.1 24.2 24.3 24.4 24.5 24.6 24.7 24.8 Chieffo C et al. (1997) Isolation and characterization of a gene from the DiGeorge chromosomal region homologous to the mouse Tbx1 gene. Genomics 43: 267-77 PubMed GONUTS page
- ↑ 25.0 25.1 25.2 Fagman H et al. (2007) The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum Mol Genet 16: 276-85 PubMed GONUTS page
- ↑ 26.0 26.1 Grifone R et al. (2008) Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn 237: 3071-8 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 27.3 Nowotschin S et al. (2006) Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development 133: 1565-73 PubMed GONUTS page
- ↑ 28.0 28.1 Kelly RG et al. (2004) The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet 13: 2829-40 PubMed GONUTS page
- ↑ 29.0 29.1 29.2 Jerome LA & Papaioannou VE (2001) DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet 27: 286-91 PubMed GONUTS page
- ↑ 30.0 30.1 Merscher S et al. (2001) TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104: 619-29 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Arnold JS et al. (2006) Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet 15: 1629-39 PubMed GONUTS page
- ↑ 32.0 32.1 Xu H et al. (2005) Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development 132: 4387-95 PubMed GONUTS page
- ↑ Calmont A et al. (2011) Absence of the vagus nerve in the stomach of Tbx1-/- mutant mice. Neurogastroenterol Motil 23: 125-30 PubMed GONUTS page
- ↑ 34.0 34.1 34.2 34.3 Catón J et al. (2009) Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol 328: 493-505 PubMed GONUTS page
- ↑ 35.0 35.1 35.2 35.3 Lania G et al. (2009) Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol 328: 109-17 PubMed GONUTS page
- ↑ 36.0 36.1 Paylor R et al. (2006) Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A 103: 7729-34 PubMed GONUTS page
- ↑ Vitelli F et al. (2003) TBX1 is required for inner ear morphogenesis. Hum Mol Genet 12: 2041-8 PubMed GONUTS page
- ↑ 38.0 38.1 38.2 Okano J et al. (2008) Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Dev Dyn 237: 3059-70 PubMed GONUTS page
- ↑ 39.0 39.1 Chen L et al. (2009) Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res 105: 842-51 PubMed GONUTS page
- ↑ Stoller JZ & Epstein JA (2005) Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Hum Mol Genet 14: 885-92 PubMed GONUTS page
- ↑ Takeuchi JK et al. (2005) Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-74 PubMed GONUTS page
- ↑ 42.0 42.1 Sambasivan R et al. (2009) Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates. Dev Cell 16: 810-21 PubMed GONUTS page
- ↑ 43.0 43.1 Randall V et al. (2009) Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest 119: 3301-10 PubMed GONUTS page
- ↑ Calmont A et al. (2009) Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development 136: 3173-83 PubMed GONUTS page
- ↑ 45.0 45.1 Xu H et al. (2007) Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol 302: 670-82 PubMed GONUTS page
- ↑ 46.0 46.1 Xu H et al. (2007) In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol 310: 329-40 PubMed GONUTS page
