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MGI:T
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | T ( synonyms: Bra, T1 ) | |
| Protein Name(s) | brachyury, | |
| External Links | ||
| MGI | MGI:98472 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000785 |
chromatin |
MGI:MGI:5307952 |
IMP: Inferred from Mutant Phenotype |
C |
From MGI |
|||
| GO:0000790 |
nuclear chromatin |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0000980 |
RNA polymerase II distal enhancer sequence-specific DNA binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0000981 |
sequence-specific DNA binding RNA polymerase II transcription factor activity |
MGI:MGI:77340 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0001570 |
vasculogenesis |
MGI:MGI:3701028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856185 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:3056222 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3042264 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:3701028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856158 |
P |
From MGI |
||
| GO:0001756 |
somitogenesis |
MGI:MGI:64493 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0001839 |
neural plate morphogenesis |
MGI:MGI:3056222 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3042264 |
P |
From MGI |
||
| GO:0001843 |
neural tube closure |
MGI:MGI:3701028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856158 |
P |
From MGI |
||
| GO:0003007 |
heart morphogenesis |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003257 |
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0003257 |
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
MGI:MGI:5307952 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0003700 |
sequence-specific DNA binding transcription factor activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR008967 |
F |
From MGI |
||
| GO:0003705 |
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3654744 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:64493 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:77340 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3701028 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR008967 |
P |
From MGI |
||
| GO:0006357 |
regulation of transcription from RNA polymerase II promoter |
MGI:MGI:77340 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007275 |
multicellular organismal development |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0217 |
P |
From MGI |
||
| GO:0007341 |
penetration of zona pellucida |
MGI:MGI:71219 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856570 |
P |
From MGI |
||
| GO:0007498 |
mesoderm development |
MGI:MGI:64493 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0007509 |
mesoderm migration involved in gastrulation |
MGI:MGI:71468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3701028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856185 |
P |
From MGI |
||
| GO:0009653 |
anatomical structure morphogenesis |
MGI:MGI:3701028 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856185 |
P |
From MGI |
||
| GO:0009952 |
anterior/posterior pattern specification |
MGI:MGI:3056222 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3042262 |
P |
From MGI |
||
| GO:0014028 |
notochord formation |
MGI:MGI:77191 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856184 |
P |
From MGI |
||
| GO:0022414 |
reproductive process |
MGI:MGI:54366 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856562 |
P |
From MGI |
||
| GO:0023019 |
signal transduction involved in regulation of gene expression |
MGI:MGI:4415813 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030509 |
BMP signaling pathway |
MGI:MGI:3703823 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0030903 |
notochord development |
MGI:MGI:3056222 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3042264 |
P |
From MGI |
||
| GO:0030903 |
notochord development |
MGI:MGI:64493 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0030903 |
notochord development |
MGI:MGI:64560 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856185 |
P |
From MGI |
||
| GO:0035121 |
tail morphogenesis |
MGI:MGI:1927252 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1927715 |
P |
From MGI |
||
| GO:0035121 |
tail morphogenesis |
MGI:MGI:54366 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856737 |
P |
From MGI |
||
| GO:0035121 |
tail morphogenesis |
MGI:MGI:64493 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0035121 |
tail morphogenesis |
MGI:MGI:71468 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:1927252 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:3654744 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:62384 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:77340 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045944 |
positive regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3654744 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:96787 |
P |
From MGI |
||
| GO:0048706 |
embryonic skeletal system development |
MGI:MGI:64493 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1857760 |
P |
From MGI |
||
| GO:0060070 |
canonical Wnt receptor signaling pathway |
MGI:MGI:3703823 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0060349 |
bone morphogenesis |
MGI:MGI:1927252 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:1927715 |
P |
From MGI |
||
| GO:0060395 |
SMAD protein signal transduction |
MGI:MGI:1195384 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0061371 |
determination of heart left/right asymmetry |
MGI:MGI:1328649 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:1856184 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 David R et al. (2011) Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell. Cardiovasc Res 92: 115-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Kispert A et al. (1995) The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J 14: 4763-72 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Inman KE & Downs KM (2006) Brachyury is required for elongation and vasculogenesis in the murine allantois. Development 133: 2947-59 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Bogani D et al. (2004) New semidominant mutations that affect mouse development. Genesis 40: 109-117 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Kispert A & Herrmann BG (1994) Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol 161: 179-93 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103: 10294-9 PubMed GONUTS page
- ↑ Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ Johnson LR et al. (1995) Sperm from mice carrying one or two t haplotypes are deficient in investment and oocyte penetration. Dev Biol 168: 138-49 PubMed GONUTS page
- ↑ 9.0 9.1 Wilson V et al. (1995) The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development 121: 877-86 PubMed GONUTS page
- ↑ Rennebeck GM et al. (1995) Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol 172: 206-17 PubMed GONUTS page
- ↑ 11.0 11.1 Lyon MF & Bechtol KB (1977) Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res 30: 63-76 PubMed GONUTS page
- ↑ Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell 2: 497-507 PubMed GONUTS page
- ↑ 13.0 13.1 Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A 104: 3859-64 PubMed GONUTS page
- ↑ Dietrich S et al. (1993) Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev 44: 189-207 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Harrison SM et al. (2000) Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury. Dev Biol 227: 358-72 PubMed GONUTS page
- ↑ Kispert A & Herrmann BG (1993) The Brachyury gene encodes a novel DNA binding protein. EMBO J 12: 3211-20 PubMed GONUTS page
- ↑ Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-19 PubMed GONUTS page
- ↑ King T et al. (1998) The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79: 29-37 PubMed GONUTS page
