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MGI:Syp
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Syp ( synonyms: p38, Syn, Syp I ) | |
| Protein Name(s) | synaptophysin, | |
| External Links | ||
| MGI | MGI:98467 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005215 |
transporter activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3814973 |
IPI: Inferred from Physical Interaction |
UniProtKB:Q8K021 |
F |
From MGI |
||
| GO:0005624 |
membrane fraction |
MGI:MGI:3531593 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006810 |
transport |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:2387907 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0006897 |
endocytosis |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0007268 |
synaptic transmission |
MGI:MGI:2387907 |
TAS: Traceable Author Statement |
P |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:1099676 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:2176305 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:2385986 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:2681378 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0008021 |
synaptic vesicle |
MGI:MGI:3613132 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0015485 |
cholesterol binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0016020 |
membrane |
MGI:MGI:3814973 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0016021 |
integral to membrane |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0812 |
C |
From MGI |
||
| GO:0017075 |
syntaxin-1 binding |
MGI:MGI:76787 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:2387814 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:3692803 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:4941854 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019717 |
synaptosome |
MGI:MGI:5286805 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0019904 |
protein domain specific binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0030054 |
cell junction |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0965 |
C |
From MGI |
||
| GO:0030285 |
integral to synaptic vesicle membrane |
MGI:MGI:2387907 |
TAS: Traceable Author Statement |
C |
From MGI |
|||
| GO:0030672 |
synaptic vesicle membrane |
MGI:MGI:2664026 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0030672 |
synaptic vesicle membrane |
MGI:MGI:3042561 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0031410 |
cytoplasmic vesicle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0968 |
C |
From MGI |
||
| GO:0032403 |
protein complex binding |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0042169 |
SH2 domain binding |
MGI:MGI:3814973 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:3052624 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042734 |
presynaptic membrane |
MGI:MGI:4367324 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042802 |
identical protein binding |
MGI:MGI:3814973 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0043229 |
intracellular organelle |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0043234 |
protein complex |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0044306 |
neuron projection terminus |
MGI:MGI:2181231 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044306 |
neuron projection terminus |
MGI:MGI:3604278 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0044306 |
neuron projection terminus |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:2179537 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:2449890 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:2680876 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:3690211 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:3758357 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0045202 |
synapse |
MGI:MGI:3814973 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0048169 |
regulation of long-term neuronal synaptic plasticity |
MGI:MGI:1349221 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048172 |
regulation of short-term neuronal synaptic plasticity |
MGI:MGI:1349221 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0048786 |
presynaptic active zone |
MGI:MGI:5286805 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0060076 |
excitatory synapse |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0071310 |
cellular response to organic substance |
MGI:MGI:3801567 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:2000474 |
regulation of opioid receptor signaling pathway |
MGI:MGI:4417868 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Felkl M & Leube RE (2008) Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin. Neuroscience 156: 344-52 PubMed GONUTS page
- ↑ Trinidad JC et al. (2005) Phosphorylation state of postsynaptic density proteins. J Neurochem 92: 1306-16 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Singec I et al. (2002) Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons. J Comp Neurol 452: 139-53 PubMed GONUTS page
- ↑ Shibata T et al. (1997) Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci 17: 9212-9 PubMed GONUTS page
- ↑ Di Paolo G et al. (2002) Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron 33: 789-804 PubMed GONUTS page
- ↑ Biederer T et al. (2002) SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 297: 1525-31 PubMed GONUTS page
- ↑ Belfort GM & Kandror KV (2003) Cellugyrin and synaptogyrin facilitate targeting of synaptophysin to a ubiquitous synaptic vesicle-sized compartment in PC12 cells. J Biol Chem 278: 47971-8 PubMed GONUTS page
- ↑ Fukuda M (2006) Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport 17: 179-82 PubMed GONUTS page
- ↑ McMahon HT et al. (1995) Complexins: cytosolic proteins that regulate SNAP receptor function. Cell 83: 111-9 PubMed GONUTS page
- ↑ Wilson SM et al. (2002) Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet 32: 420-5 PubMed GONUTS page
- ↑ Offenhäuser N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell 127: 213-26 PubMed GONUTS page
- ↑ Samuels BA et al. (2007) Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK. Neuron 56: 823-37 PubMed GONUTS page
- ↑ 13.0 13.1 Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience 189: 32-42 PubMed GONUTS page
- ↑ Pigino G et al. (2003) Alzheimer's presenilin 1 mutations impair kinesin-based axonal transport. J Neurosci 23: 4499-508 PubMed GONUTS page
- ↑ Gitler D et al. (2004) Molecular determinants of synapsin targeting to presynaptic terminals. J Neurosci 24: 3711-20 PubMed GONUTS page
- ↑ Rüttiger L et al. (2004) Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss. Proc Natl Acad Sci U S A 101: 12922-7 PubMed GONUTS page
- ↑ Stephenson DT et al. (2009) Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species. J Histochem Cytochem 57: 933-49 PubMed GONUTS page
- ↑ Jellali A et al. (2002) Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. J Comp Neurol 449: 76-87 PubMed GONUTS page
- ↑ Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res 43: 39-56 PubMed GONUTS page
- ↑ Adams ME et al. (2000) Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin. J Cell Biol 150: 1385-98 PubMed GONUTS page
- ↑ Brandon EP et al. (2003) Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci 23: 539-49 PubMed GONUTS page
- ↑ Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron 40: 719-31 PubMed GONUTS page
- ↑ Pellet JB et al. (2000) Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. Eur J Neurosci 12: 621-32 PubMed GONUTS page
- ↑ Tabuchi K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science 318: 71-6 PubMed GONUTS page
- ↑ 25.0 25.1 Janz R et al. (1999) Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24: 687-700 PubMed GONUTS page
- ↑ Pickford F et al. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 118: 2190-9 PubMed GONUTS page
