MGI:Syk

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Annotations

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes
	GO:0000166	nucleotide binding	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0547	F	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0000187	activation of MAPK activity	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0001525	angiogenesis	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0037	P	From MGI
	GO:0001820	serotonin secretion	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0001945	lymph vessel development	MGI:MGI:3653293 PMID:12522250^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002281	macrophage activation involved in immune response	MGI:MGI:3693026 PMID:17086186^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002283	neutrophil activation involved in immune response	MGI:MGI:3693026 PMID:17086186^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002366	leukocyte activation involved in immune response	MGI:MGI:3576850 PMID:15845454^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0002554	serotonin secretion by platelet	MGI:MGI:87668 PMID:9171347^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0004672	protein kinase activity	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63614	F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:1859033 PMID:10872802^[7]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:3768863 PMID:16456001^[8]	IMP: Inferred from Mutant Phenotype		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:73242 PMID:7744830^[9]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:77358 PMID:7499277^[10]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:82860 PMID:8798454^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004713	protein tyrosine kinase activity	MGI:MGI:86952 PMID:9099676^[12]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P43405	F	From MGI
	GO:0004715	non-membrane spanning protein tyrosine kinase activity	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0004716	receptor signaling protein tyrosine kinase activity	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005178	integrin binding	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P43405	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3576850 PMID:15845454^[5]	IPI: Inferred from Physical Interaction	UniProtKB:Q6QLQ4	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3690194 PMID:16713566^[13]	IPI: Inferred from Physical Interaction	UniProtKB:Q64693	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3693026 PMID:17086186^[4]	IPI: Inferred from Physical Interaction	UniProtKB:O54885 UniProtKB:P20491	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3768863 PMID:16456001^[8]	IPI: Inferred from Physical Interaction	UniProtKB:Q9Z1S8	F	From MGI
	GO:0005515	protein binding	MGI:MGI:3827034 PMID:19124738^[14]	IPI: Inferred from Physical Interaction	UniProtKB:Q9D3G9	F	From MGI
	GO:0005524	ATP binding	MGI:MGI:82860 PMID:8798454^[11]	IDA: Inferred from Direct Assay		F	From MGI
	GO:0005622	intracellular	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	C	From MGI
	GO:0005623	cell	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	C	From MGI
	GO:0005623	cell	MGI:MGI:87668 PMID:9171347^[6]	IMP: Inferred from Mutant Phenotype		C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0963	C	From MGI
	GO:0005737	cytoplasm	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR020757 InterPro:IPR012234	C	From MGI
	GO:0005886	plasma membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-1003	C	From MGI
	GO:0006468	protein phosphorylation	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635 InterPro:IPR020757 InterPro:IPR012234	P	From MGI
	GO:0007159	leukocyte cell-cell adhesion	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P43405	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0007166	cell surface receptor signaling pathway	MGI:MGI:86952 PMID:9099676^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007167	enzyme linked receptor protein signaling pathway	MGI:MGI:73242 PMID:7744830^[9]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0007186	G-protein coupled receptor signaling pathway	MGI:MGI:2153366 PMID:11676469^[15]	TAS: Traceable Author Statement		P	From MGI
	GO:0007229	integrin-mediated signaling pathway	MGI:MGI:3693026 PMID:17086186^[4]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007229	integrin-mediated signaling pathway	MGI:MGI:5306324 PMID:11940607^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0007257	activation of JUN kinase activity	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0010543	regulation of platelet activation	MGI:MGI:87668 PMID:9171347^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0016020	membrane	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0472	C	From MGI
	GO:0016301	kinase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	F	From MGI
	GO:0016310	phosphorylation	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0418	P	From MGI
	GO:0016740	transferase activity	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0808	F	From MGI
	GO:0016772	transferase activity, transferring phosphorus-containing groups	MGI:MGI:2152098	IEA: Inferred from Electronic Annotation	InterPro:IPR011009	F	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:1859033 PMID:10872802^[7]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:3768863 PMID:16456001^[8]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:77358 PMID:7499277^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:82860 PMID:8798454^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0018108	peptidyl-tyrosine phosphorylation	MGI:MGI:86952 PMID:9099676^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0019370	leukotriene biosynthetic process	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0019815	B cell receptor complex	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0019901	protein kinase binding	MGI:MGI:3640451 PMID:11672534^[17]	IPI: Inferred from Physical Interaction	UniProtKB:P14234	F	From MGI
	GO:0019904	protein domain specific binding	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63614	F	From MGI
	GO:0030593	neutrophil chemotaxis	MGI:MGI:4834177	ISO: Inferred from Sequence Orthology	UniProtKB:P43405	P	From MGI
	GO:0031410	cytoplasmic vesicle	MGI:MGI:1354194	IEA: Inferred from Electronic Annotation	UniProtKB-KW:KW-0968	C	From MGI
	GO:0032009	early phagosome	MGI:MGI:3576850 PMID:15845454^[5]	IDA: Inferred from Direct Assay		C	From MGI
	GO:0032928	regulation of superoxide anion generation	MGI:MGI:4414596 PMID:19797524^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0033630	positive regulation of cell adhesion mediated by integrin	MGI:MGI:5306324 PMID:11940607^[16]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0035556	intracellular signal transduction	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0042101	T cell receptor complex	MGI:MGI:2154458	ISO: Inferred from Sequence Orthology	UniProtKB:P43405	C	From MGI
	GO:0042742	defense response to bacterium	MGI:MGI:4414596 PMID:19797524^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043306	positive regulation of mast cell degranulation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63614	P	From MGI
	GO:0043306	positive regulation of mast cell degranulation	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0043313	regulation of neutrophil degranulation	MGI:MGI:4414596 PMID:19797524^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0043366	beta selection	MGI:MGI:1096306 PMID:9275205^[19]	IGI: Inferred from Genetic Interaction	MGI:MGI:99613	P	From MGI
	GO:0045087	innate immune response	MGI:MGI:3576850 PMID:15845454^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0045401	positive regulation of interleukin-3 biosynthetic process	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0045579	positive regulation of B cell differentiation	MGI:MGI:77314 PMID:7477352^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0045579	positive regulation of B cell differentiation	MGI:MGI:77315 PMID:7477353^[21]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857421	P	From MGI
	GO:0045588	positive regulation of gamma-delta T cell differentiation	MGI:MGI:77314 PMID:7477352^[20]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0045588	positive regulation of gamma-delta T cell differentiation	MGI:MGI:83585 PMID:8790395^[22]	IMP: Inferred from Mutant Phenotype	MGI:MGI:1857421	P	From MGI
	GO:0045780	positive regulation of bone resorption	MGI:MGI:3703840 PMID:17353363^[23]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0046638	positive regulation of alpha-beta T cell differentiation	MGI:MGI:1096306 PMID:9275205^[19]	IGI: Inferred from Genetic Interaction	MGI:MGI:99613	P	From MGI
	GO:0046641	positive regulation of alpha-beta T cell proliferation	MGI:MGI:1096306 PMID:9275205^[19]	IGI: Inferred from Genetic Interaction	MGI:MGI:99613	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63614	P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:82860 PMID:8798454^[11]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0046777	protein autophosphorylation	MGI:MGI:86952 PMID:9099676^[12]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0048514	blood vessel morphogenesis	MGI:MGI:3653293 PMID:12522250^[3]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050715	positive regulation of cytokine secretion	MGI:MGI:4365650 PMID:19770268^[24]	IGI: Inferred from Genetic Interaction	MGI:MGI:2157947	P	From MGI
	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0050764	regulation of phagocytosis	MGI:MGI:4414596 PMID:19797524^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0050776	regulation of immune response	MGI:MGI:4417868	ISO: Inferred from Sequence Orthology	UniProtKB:Q63614	P	From MGI
	GO:0050850	positive regulation of calcium-mediated signaling	MGI:MGI:85068 PMID:9000133^[2]	IMP: Inferred from Mutant Phenotype	MGI:MGI:2384078	P	From MGI
	GO:0050853	B cell receptor signaling pathway	MGI:MGI:77358 PMID:7499277^[10]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0050853	B cell receptor signaling pathway	MGI:MGI:79455 PMID:8626447^[1]	IDA: Inferred from Direct Assay		P	From MGI
	GO:0070372	regulation of ERK1 and ERK2 cascade	MGI:MGI:4414596 PMID:19797524^[18]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0071226	cellular response to molecule of fungal origin	MGI:MGI:3576850 PMID:15845454^[5]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090237	regulation of arachidonic acid secretion	MGI:MGI:87668 PMID:9171347^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
	GO:0090330	regulation of platelet aggregation	MGI:MGI:87668 PMID:9171347^[6]	IMP: Inferred from Mutant Phenotype		P	From MGI
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem 271: 6458-66 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13: 2595-605 PubMed GONUTS page
↑ ^3.0 ^3.1 Abtahian F et al. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299: 247-51 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Mócsai A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7: 1326-33 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Rogers NC et al. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22: 507-17 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Poole A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 16: 2333-41 PubMed GONUTS page
↑ ^7.0 ^7.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Yu M et al. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol 176: 2421-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Sillman AL & Monroe JG (1995) Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes. J Biol Chem 270: 11806-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Latour S et al. (1996) Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem 271: 22782-90 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Keshvara LM et al. (1997) Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem 272: 10377-81 PubMed GONUTS page
↑ Siegel R et al. (2006) Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Cell 125: 761-74 PubMed GONUTS page
↑ Oda H et al. (2009) RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells. J Immunol 182: 957-62 PubMed GONUTS page
↑ Yanagi S et al. (2001) Syk expression and novel function in a wide variety of tissues. Biochem Biophys Res Commun 288: 495-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Obergfell A et al. (2002) Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 157: 265-75 PubMed GONUTS page
↑ Vines CM et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15: 507-19 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Van Ziffle JA & Lowell CA (2009) Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114: 4871-82 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Cheng AM et al. (1997) The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc Natl Acad Sci U S A 94: 9797-801 PubMed GONUTS page
↑ ^20.0 ^20.1 Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page
↑ Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378: 303-6 PubMed GONUTS page
↑ Mallick-Wood CA et al. (1996) Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proc Natl Acad Sci U S A 93: 9704-9 PubMed GONUTS page
↑ Zou W et al. (2007) Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 176: 877-88 PubMed GONUTS page
↑ Tanne A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med 206: 2205-20 PubMed GONUTS page

[PMID:8626447-0] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Richards JD et al. (1996) Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem 271: 6458-66 PubMed GONUTS page

[PMID:9000133-1] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 Costello PS et al. (1996) Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells. Oncogene 13: 2595-605 PubMed GONUTS page

[PMID:12522250-2] 3.0 ^3.1 Abtahian F et al. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299: 247-51 PubMed GONUTS page

[PMID:17086186-3] 4.0 ^4.1 ^4.2 ^4.3 Mócsai A et al. (2006) Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol 7: 1326-33 PubMed GONUTS page

[PMID:15845454-4] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Rogers NC et al. (2005) Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity 22: 507-17 PubMed GONUTS page

[PMID:9171347-5] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Poole A et al. (1997) The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 16: 2333-41 PubMed GONUTS page

[PMID:10872802-6] 7.0 ^7.1 Iseki M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem Biophys Res Commun 272: 45-54 PubMed GONUTS page

[PMID:16456001-7] 8.0 ^8.1 ^8.2 Yu M et al. (2006) Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI. J Immunol 176: 2421-9 PubMed GONUTS page

[PMID:7744830-8] 9.0 ^9.1 Sillman AL & Monroe JG (1995) Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes. J Biol Chem 270: 11806-11 PubMed GONUTS page

[PMID:7499277-9] 10.0 ^10.1 ^10.2 Katagiri T et al. (1995) Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells. J Biol Chem 270: 27987-90 PubMed GONUTS page

[PMID:8798454-10] 11.0 ^11.1 ^11.2 ^11.3 Latour S et al. (1996) Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. J Biol Chem 271: 22782-90 PubMed GONUTS page

[PMID:9099676-11] 12.0 ^12.1 ^12.2 ^12.3 Keshvara LM et al. (1997) Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem 272: 10377-81 PubMed GONUTS page

[PMID:16713566-12] Siegel R et al. (2006) Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Cell 125: 761-74 PubMed GONUTS page

[PMID:19124738-13] Oda H et al. (2009) RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells. J Immunol 182: 957-62 PubMed GONUTS page

[PMID:11676469-14] Yanagi S et al. (2001) Syk expression and novel function in a wide variety of tissues. Biochem Biophys Res Commun 288: 495-8 PubMed GONUTS page

[PMID:11940607-15] 16.0 ^16.1 Obergfell A et al. (2002) Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol 157: 265-75 PubMed GONUTS page

[PMID:11672534-16] Vines CM et al. (2001) Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 15: 507-19 PubMed GONUTS page

[PMID:19797524-17] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Van Ziffle JA & Lowell CA (2009) Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood 114: 4871-82 PubMed GONUTS page

[PMID:9275205-18] 19.0 ^19.1 ^19.2 Cheng AM et al. (1997) The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling. Proc Natl Acad Sci U S A 94: 9797-801 PubMed GONUTS page

[PMID:7477352-19] 20.0 ^20.1 Turner M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378: 298-302 PubMed GONUTS page

[PMID:7477353-20] Cheng AM et al. (1995) Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378: 303-6 PubMed GONUTS page

[PMID:8790395-21] Mallick-Wood CA et al. (1996) Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proc Natl Acad Sci U S A 93: 9704-9 PubMed GONUTS page

[PMID:17353363-22] Zou W et al. (2007) Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 176: 877-88 PubMed GONUTS page

[PMID:19770268-23] Tanne A et al. (2009) A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J Exp Med 206: 2205-20 PubMed GONUTS page

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Species (Taxon ID)	Mus musculus (house mouse) (taxon:10090)
Gene Name(s)	Syk ( synonyms: Sykb )
Protein Name(s)	spleen tyrosine kinase,
External Links
MGI	MGI:99515

MGI:Syk

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