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MGI:Sycp3
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sycp3 ( synonyms: Cor1, Scp3 ) | |
| Protein Name(s) | synaptonemal complex protein 3, | |
| External Links | ||
| MGI | MGI:109542 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000705 |
achiasmate meiosis I |
MGI:MGI:2179610 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:1858570 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:2183707 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:2652933 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:3757893 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000793 |
condensed chromosome |
MGI:MGI:4361070 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000794 |
condensed nuclear chromosome |
MGI:MGI:3774244 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:2664436 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3027482 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3528534 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3615835 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3664716 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3695528 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3719060 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:3770581 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000795 |
synaptonemal complex |
MGI:MGI:4457793 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000800 |
lateral element |
MGI:MGI:1352918 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000800 |
lateral element |
MGI:MGI:4452449 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0000802 |
transverse filament |
MGI:MGI:3578071 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0001673 |
male germ cell nucleus |
MGI:MGI:3719060 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003677 |
DNA binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0238 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:2667549 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0539 |
C |
From MGI |
||
| GO:0007049 |
cell cycle |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0131 |
P |
From MGI |
||
| GO:0007066 |
female meiosis sister chromatid cohesion |
MGI:MGI:3578071 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007067 |
mitosis |
MGI:MGI:1858570 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007126 |
meiosis |
MGI:MGI:2183707 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007129 |
synapsis |
MGI:MGI:3578071 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:2179041 |
P |
From MGI |
||
| GO:0007130 |
synaptonemal complex assembly |
MGI:MGI:1352918 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0007283 |
spermatogenesis |
MGI:MGI:1352918 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016321 |
female meiosis chromosome segregation |
MGI:MGI:2179610 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0035093 |
spermatogenesis, exchange of chromosomal proteins |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0043066 |
negative regulation of apoptotic process |
MGI:MGI:1352918 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0046982 |
protein heterodimerization activity |
MGI:MGI:3653558 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0051301 |
cell division |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0132 |
P |
From MGI |
||
| GO:0051309 |
female meiosis chromosome separation |
MGI:MGI:3056012 |
NAS: Non-traceable Author Statement |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Yuan L et al. (2002) Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science 296: 1115-8 PubMed GONUTS page
- ↑ 2.0 2.1 Kneitz B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev 14: 1085-97 PubMed GONUTS page
- ↑ 3.0 3.1 Lipkin SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet 31: 385-90 PubMed GONUTS page
- ↑ Kwan KY et al. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A 100: 2526-31 PubMed GONUTS page
- ↑ Ward JO et al. (2007) Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet 3: e139 PubMed GONUTS page
- ↑ Kudo NR et al. (2009) Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci 122: 2686-98 PubMed GONUTS page
- ↑ Yang F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev 22: 682-91 PubMed GONUTS page
- ↑ Tay J et al. (2003) Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev 17: 1457-62 PubMed GONUTS page
- ↑ Kuramochi-Miyagawa S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131: 839-49 PubMed GONUTS page
- ↑ Baarends WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 25: 1041-53 PubMed GONUTS page
- ↑ Wesoly J et al. (2006) Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol 26: 976-89 PubMed GONUTS page
- ↑ Hamer G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J Cell Sci 119: 4025-32 PubMed GONUTS page
- ↑ Hosokawa M et al. (2007) Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol 301: 38-52 PubMed GONUTS page
- ↑ 14.0 14.1 Li XC & Schimenti JC (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet 3: e130 PubMed GONUTS page
- ↑ Paul C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS One 2: e989 PubMed GONUTS page
- ↑ Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev 24: 1266-80 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 17.3 Yuan L et al. (2000) The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell 5: 73-83 PubMed GONUTS page
- ↑ Ollinger R et al. (2008) Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice. PLoS Genet 4: e1000199 PubMed GONUTS page
- ↑ 19.0 19.1 19.2 Kouznetsova A et al. (2005) SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J Cell Sci 118: 2271-8 PubMed GONUTS page
- ↑ Lee J et al. (2003) Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci 116: 2781-90 PubMed GONUTS page
- ↑ Yang F et al. (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173: 497-507 PubMed GONUTS page
- ↑ Lightfoot DA & Höög C (2004) Low level chromosome instability in embryonic cells of primary aneuploid mice. Cytogenet Genome Res 107: 95-8 PubMed GONUTS page