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MGI:Sycp3

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Contents

Species (Taxon ID) Mus musculus (house mouse) (taxon:10090)
Gene Name(s) Sycp3 ( synonyms: Cor1, Scp3 )
Protein Name(s) synaptonemal complex protein 3,
External Links
MGI MGI:109542

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000705

achiasmate meiosis I

MGI:MGI:2179610
PMID:12004129[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0000793

condensed chromosome

MGI:MGI:1858570
PMID:10809667[2]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000793

condensed chromosome

MGI:MGI:2183707
PMID:12091911[3]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000793

condensed chromosome

MGI:MGI:2652933
PMID:12591952[4]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000793

condensed chromosome

MGI:MGI:3757893
PMID:17784788[5]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000793

condensed chromosome

MGI:MGI:4361070
PMID:19625504[6]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000794

condensed nuclear chromosome

MGI:MGI:3774244
PMID:18316482[7]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:2664436
PMID:12815066[8]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3027482
PMID:14736746[9]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3528534
PMID:15657431[10]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3615835
PMID:16428451[11]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3664716
PMID:16968740[12]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3695528
PMID:17141210[13]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3719060
PMID:17696610[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:3770581
PMID:17912366[15]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000795

synaptonemal complex

MGI:MGI:4457793
PMID:20551173[16]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000800

lateral element

MGI:MGI:1352918
PMID:10678170[17]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000800

lateral element

MGI:MGI:4452449
PMID:18802469[18]

IDA: Inferred from Direct Assay

C

From MGI

GO:0000802

transverse filament

MGI:MGI:3578071
PMID:15870106[19]

IDA: Inferred from Direct Assay

C

From MGI

GO:0001673

male germ cell nucleus

MGI:MGI:3719060
PMID:17696610[14]

IDA: Inferred from Direct Assay

C

From MGI

GO:0003677

DNA binding

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

From MGI

GO:0005515

protein binding

MGI:MGI:2667549
PMID:12759374[20]

IPI: Inferred from Physical Interaction

UniProtKB:Q8C5S7
UniProtKB:Q920F6
UniProtKB:Q9CW03

F

From MGI

GO:0005634

nucleus

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From MGI

GO:0007049

cell cycle

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From MGI

GO:0007066

female meiosis sister chromatid cohesion

MGI:MGI:3578071
PMID:15870106[19]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007067

mitosis

MGI:MGI:1858570
PMID:10809667[2]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007126

meiosis

MGI:MGI:2183707
PMID:12091911[3]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007129

synapsis

MGI:MGI:3578071
PMID:15870106[19]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2179041

P

From MGI

GO:0007130

synaptonemal complex assembly

MGI:MGI:1352918
PMID:10678170[17]

IDA: Inferred from Direct Assay

P

From MGI

GO:0007283

spermatogenesis

MGI:MGI:1352918
PMID:10678170[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0016321

female meiosis chromosome segregation

MGI:MGI:2179610
PMID:12004129[1]

IDA: Inferred from Direct Assay

P

From MGI

GO:0035093

spermatogenesis, exchange of chromosomal proteins

MGI:MGI:4834177

ISO: Inferred from Sequence Orthology

UniProtKB:Q8IZU3

P

From MGI

GO:0043066

negative regulation of apoptotic process

MGI:MGI:1352918
PMID:10678170[17]

IMP: Inferred from Mutant Phenotype

P

From MGI

GO:0046982

protein heterodimerization activity

MGI:MGI:3653558
PMID:16717126[21]

IPI: Inferred from Physical Interaction

UniProtKB:Q9CUU3

F

From MGI

GO:0051301

cell division

MGI:MGI:1354194

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From MGI

GO:0051309

female meiosis chromosome separation

MGI:MGI:3056012
PMID:15305061[22]

NAS: Non-traceable Author Statement

P

From MGI


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 Yuan L et al. (2002) Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3. Science 296: 1115-8 PubMed GONUTS page
  2. 2.0 2.1 Kneitz B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev 14: 1085-97 PubMed GONUTS page
  3. 3.0 3.1 Lipkin SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet 31: 385-90 PubMed GONUTS page
  4. Kwan KY et al. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A 100: 2526-31 PubMed GONUTS page
  5. Ward JO et al. (2007) Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS Genet 3: e139 PubMed GONUTS page
  6. Kudo NR et al. (2009) Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci 122: 2686-98 PubMed GONUTS page
  7. Yang F et al. (2008) Meiotic failure in male mice lacking an X-linked factor. Genes Dev 22: 682-91 PubMed GONUTS page
  8. Tay J et al. (2003) Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev 17: 1457-62 PubMed GONUTS page
  9. Kuramochi-Miyagawa S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development 131: 839-49 PubMed GONUTS page
  10. Baarends WM et al. (2005) Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol 25: 1041-53 PubMed GONUTS page
  11. Wesoly J et al. (2006) Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol 26: 976-89 PubMed GONUTS page
  12. Hamer G et al. (2006) Characterization of a novel meiosis-specific protein within the central element of the synaptonemal complex. J Cell Sci 119: 4025-32 PubMed GONUTS page
  13. Hosokawa M et al. (2007) Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol 301: 38-52 PubMed GONUTS page
  14. 14.0 14.1 Li XC & Schimenti JC (2007) Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS Genet 3: e130 PubMed GONUTS page
  15. Paul C et al. (2007) Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS One 2: e989 PubMed GONUTS page
  16. Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev 24: 1266-80 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 Yuan L et al. (2000) The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol Cell 5: 73-83 PubMed GONUTS page
  18. Ollinger R et al. (2008) Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice. PLoS Genet 4: e1000199 PubMed GONUTS page
  19. 19.0 19.1 19.2 Kouznetsova A et al. (2005) SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J Cell Sci 118: 2271-8 PubMed GONUTS page
  20. Lee J et al. (2003) Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. J Cell Sci 116: 2781-90 PubMed GONUTS page
  21. Yang F et al. (2006) Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol 173: 497-507 PubMed GONUTS page
  22. Lightfoot DA & Höög C (2004) Low level chromosome instability in embryonic cells of primary aneuploid mice. Cytogenet Genome Res 107: 95-8 PubMed GONUTS page
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