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MGI:Suz12
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Suz12 ( synonyms: D11Ertd530e ) | |
| Protein Name(s) | suppressor of zeste 12 homolog (Drosophila), | |
| External Links | ||
| MGI | MGI:1261758 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3629244 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0001739 |
sex chromatin |
MGI:MGI:3513221 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0003682 |
chromatin binding |
MGI:MGI:3629244 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4431292 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4436818 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005622 |
intracellular |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4367296 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005694 |
chromosome |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0158 |
C |
From MGI |
||
| GO:0006351 |
transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0804 |
P |
From MGI |
||
| GO:0006355 |
regulation of transcription, DNA-dependent |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0805 |
P |
From MGI |
||
| GO:0008270 |
zinc ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0008284 |
positive regulation of cell proliferation |
MGI:MGI:3056839 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3530650 |
P |
From MGI |
||
| GO:0016568 |
chromatin modification |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0156 |
P |
From MGI |
||
| GO:0016571 |
histone methylation |
MGI:MGI:3056839 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3530650 |
P |
From MGI |
||
| GO:0016571 |
histone methylation |
MGI:MGI:3612587 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0016571 |
histone methylation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0016574 |
histone ubiquitination |
MGI:MGI:3612587 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0035064 |
methylated histone residue binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4431292 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0035098 |
ESC/E(Z) complex |
MGI:MGI:4436818 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0042054 |
histone methyltransferase activity |
MGI:MGI:2154458 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0043565 |
sequence-specific DNA binding |
MGI:MGI:4838928 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0045596 |
negative regulation of cell differentiation |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Fujimura Y et al. (2006) Distinct roles of Polycomb group gene products in transcriptionally repressed and active domains of Hoxb8. Development 133: 2371-81 PubMed GONUTS page
- ↑ de Napoles M et al. (2004) Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell 7: 663-76 PubMed GONUTS page
- ↑ 3.0 3.1 Peng JC et al. (2009) Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells. Cell 139: 1290-302 PubMed GONUTS page
- ↑ 4.0 4.1 Shen X et al. (2009) Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells. Cell 139: 1303-14 PubMed GONUTS page
- ↑ Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-33 PubMed GONUTS page
- ↑ 6.0 6.1 Pasini D et al. (2004) Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 23: 4061-71 PubMed GONUTS page
- ↑ 7.0 7.1 Cao R et al. (2005) Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 20: 845-54 PubMed GONUTS page
- ↑ Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med 207: 2493-506 PubMed GONUTS page
