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MGI:Sulf2
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sulf2 | |
| Protein Name(s) | sulfatase 2, | |
| External Links | ||
| MGI | MGI:1919293 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001822 |
kidney development |
MGI:MGI:3769052 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0002063 |
chondrocyte development |
MGI:MGI:5306560 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0003094 |
glomerular filtration |
MGI:MGI:5306737 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0003824 |
catalytic activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0004065 |
arylsulfatase activity |
MGI:MGI:2447527 |
ISO: Inferred from Sequence Orthology |
EMBL:AY101176 |
F |
From MGI |
||
| GO:0004065 |
arylsulfatase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0005509 |
calcium ion binding |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0005615 |
extracellular space |
MGI:MGI:2447527 |
ISO: Inferred from Sequence Orthology |
EMBL:AY101176 |
C |
From MGI |
||
| GO:0005783 |
endoplasmic reticulum |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0333 |
C |
From MGI |
||
| GO:0005794 |
Golgi apparatus |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
C |
From MGI |
|||
| GO:0005886 |
plasma membrane |
MGI:MGI:5306737 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0006790 |
sulfur compound metabolic process |
MGI:MGI:2447527 |
ISO: Inferred from Sequence Orthology |
EMBL:AY101176 |
P |
From MGI |
||
| GO:0008152 |
metabolic process |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
P |
From MGI |
|||
| GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
MGI:MGI:2447527 |
ISO: Inferred from Sequence Orthology |
EMBL:AY101176 |
F |
From MGI |
||
| GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0008449 |
N-acetylglucosamine-6-sulfatase activity |
MGI:MGI:5306289 |
IMP: Inferred from Mutant Phenotype |
F |
From MGI |
|||
| GO:0008484 |
sulfuric ester hydrolase activity |
MGI:MGI:2152098 |
IEA: Inferred from Electronic Annotation |
F |
From MGI |
|||
| GO:0009986 |
cell surface |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0010575 |
positive regulation vascular endothelial growth factor production |
MGI:MGI:5306737 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0014846 |
esophagus smooth muscle contraction |
MGI:MGI:3722747 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0016787 |
hydrolase activity |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0378 |
F |
From MGI |
||
| GO:0030177 |
positive regulation of Wnt receptor signaling pathway |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030201 |
heparan sulfate proteoglycan metabolic process |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0030201 |
heparan sulfate proteoglycan metabolic process |
MGI:MGI:5306289 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0032836 |
glomerular basement membrane development |
MGI:MGI:5306737 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0035860 |
glial cell-derived neurotrophic factor receptor signaling pathway |
MGI:MGI:3722747 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
MGI:MGI:3769052 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0040037 |
negative regulation of fibroblast growth factor receptor signaling pathway |
MGI:MGI:5306737 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0046872 |
metal ion binding |
MGI:MGI:1354194 |
IEA: Inferred from Electronic Annotation |
UniProtKB-KW:KW-0479 |
F |
From MGI |
||
| GO:0048706 |
embryonic skeletal system development |
MGI:MGI:3771123 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0051216 |
cartilage development |
MGI:MGI:5306560 |
IMP: Inferred from Mutant Phenotype |
P |
From MGI |
|||
| GO:0060348 |
bone development |
MGI:MGI:3769052 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
|||
| GO:0060384 |
innervation |
MGI:MGI:3722747 |
IGI: Inferred from Genetic Interaction |
P |
From MGI |
| ||
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Holst CR et al. (2007) Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One 2: e575 PubMed GONUTS page
- ↑ 2.0 2.1 Otsuki S et al. (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc Natl Acad Sci U S A 107: 10202-7 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Schumacher VA et al. (2011) WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier. J Am Soc Nephrol 22: 1286-96 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Morimoto-Tomita M et al. (2002) Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem 277: 49175-85 PubMed GONUTS page
- ↑ 5.0 5.1 Lamanna WC et al. (2008) Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling. J Biol Chem 283: 27724-35 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Ai X et al. (2007) SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation. Development 134: 3327-38 PubMed GONUTS page
- ↑ Ratzka A et al. (2008) Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn 237: 339-53 PubMed GONUTS page
