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MGI:Sufu
Contents |
| Species (Taxon ID) | Mus musculus (house mouse) (taxon:10090) | |
| Gene Name(s) | Sufu ( synonyms: Su(Fu) ) | |
| Protein Name(s) | suppressor of fused homolog (Drosophila), | |
| External Links | ||
| MGI | MGI:1345643 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:1346364 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:3616741 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0000122 |
negative regulation of transcription from RNA polymerase II promoter |
MGI:MGI:4412466 |
ISO: Inferred from Sequence Orthology |
P |
From MGI |
|||
| GO:0001843 |
neural tube closure |
MGI:MGI:3604917 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3512046 |
P |
From MGI |
||
| GO:0001947 |
heart looping |
MGI:MGI:3604917 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3512046 |
P |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:1346364 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1861566 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:1888625 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3695869 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:3841503 |
IPI: Inferred from Physical Interaction |
RefSeq:NP_001074594 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:4359116 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:4440990 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005515 |
protein binding |
MGI:MGI:5009176 |
IPI: Inferred from Physical Interaction |
UniProtKB:O55128 |
F |
From MGI |
||
| GO:0005515 |
protein binding |
MGI:MGI:5292436 |
IPI: Inferred from Physical Interaction |
F |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:3692156 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005634 |
nucleus |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:1346364 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3608582 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:3608582 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95727 |
C |
From MGI |
||
| GO:0005737 |
cytoplasm |
MGI:MGI:4412466 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4440990 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0005737 |
cytoplasm |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
C |
From MGI |
|||
| GO:0005929 |
cilium |
MGI:MGI:3692156 |
IDA: Inferred from Direct Assay |
C |
From MGI |
|||
| GO:0007368 |
determination of left/right symmetry |
MGI:MGI:3604917 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3512046 |
P |
From MGI |
||
| GO:0008013 |
beta-catenin binding |
MGI:MGI:3702247 |
IDA: Inferred from Direct Assay |
F |
From MGI |
|||
| GO:0008134 |
transcription factor binding |
MGI:MGI:4412466 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0019901 |
protein kinase binding |
MGI:MGI:4834177 |
ISO: Inferred from Sequence Orthology |
F |
From MGI |
|||
| GO:0021513 |
spinal cord dorsal/ventral patterning |
MGI:MGI:3616741 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3619046 |
P |
From MGI |
||
| GO:0042994 |
cytoplasmic sequestering of transcription factor |
MGI:MGI:3608582 |
IGI: Inferred from Genetic Interaction |
MGI:MGI:95727 |
P |
From MGI |
||
| GO:0043588 |
skin development |
MGI:MGI:3616741 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3619046 |
P |
From MGI |
||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
MGI:MGI:1346364 |
IDA: Inferred from Direct Assay |
P |
From MGI |
|||
| GO:0045879 |
negative regulation of smoothened signaling pathway |
MGI:MGI:3616741 |
IMP: Inferred from Mutant Phenotype |
MGI:MGI:3619046 |
P |
From MGI |
| |
| edit table |
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Ding Q et al. (1999) Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol 9: 1119-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Svärd J et al. (2006) Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell 10: 187-97 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Stone DM et al. (1999) Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci 112 ( Pt 23): 4437-48 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Cooper AF et al. (2005) Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development 132: 4407-17 PubMed GONUTS page
- ↑ Simon-Chazottes D et al. (2000) Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner. Mamm Genome 11: 614-21 PubMed GONUTS page
- ↑ Delattre M et al. (1999) The Suppressor of fused gene, involved in Hedgehog signal transduction in Drosophila, is conserved in mammals. Dev Genes Evol 209: 294-300 PubMed GONUTS page
- ↑ Takenaka K et al. (2007) GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells. Biochem Biophys Res Commun 353: 501-8 PubMed GONUTS page
- ↑ Norman RX et al. (2009) Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet 18: 1740-54 PubMed GONUTS page
- ↑ Endoh-Yamagami S et al. (2009) The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol 19: 1320-6 PubMed GONUTS page
- ↑ 10.0 10.1 Humke EW et al. (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24: 670-82 PubMed GONUTS page
- ↑ Paces-Fessy M et al. (2004) The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. Biochem J 378: 353-62 PubMed GONUTS page
- ↑ Li B et al. (2011) Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs. Hum Mol Genet 20: 4155-66 PubMed GONUTS page
- ↑ 13.0 13.1 Haycraft CJ et al. (2005) Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet 1: e53 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Barnfield PC et al. (2005) Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation 73: 397-405 PubMed GONUTS page
- ↑ Meng X et al. (2001) Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 276: 40113-9 PubMed GONUTS page
